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FOXR1 forkhead box R1 [ Homo sapiens (human) ]

Gene ID: 283150, updated on 12-Aug-2022

Summary

Official Symbol
FOXR1provided by HGNC
Official Full Name
forkhead box R1provided by HGNC
Primary source
HGNC:HGNC:29980
See related
Ensembl:ENSG00000176302 MIM:615755; AllianceGenome:HGNC:29980
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FOXN5; DLNB13
Summary
This gene encodes a member of the forkhead box (FOX) family of transcription factors. FOX family members are monomeric, helix-turn-helix proteins with a core DNA-binding domain of approximately 110 aa. Many FOX transcription factors play roles in determining cell fates during early development. This forkhead box protein lacks the C-terminal basic region found in many other FOX family members. It is located within the 11q23.3 region which is commonly deleted in neuroblastomas. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward testis (RPKM 1.2) See more
Orthologs
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Genomic context

See FOXR1 in Genome Data Viewer
Location:
11q23.3
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (118971761..118981287)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (118992171..119001685)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (118842471..118851997)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 688, pseudogene Neighboring gene uroplakin 2 Neighboring gene uncharacterized LOC124902768 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:118869213-118870412 Neighboring gene centrosomal AT-AC splicing factor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC149486

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
forkhead box protein R1
Names
forkhead box protein N5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181721.3NP_859072.1  forkhead box protein R1

    See identical proteins and their annotated locations for NP_859072.1

    Status: REVIEWED

    Source sequence(s)
    AB094092, AP003392, BC038969
    Consensus CDS
    CCDS31688.1
    UniProtKB/Swiss-Prot
    Q6PIV2, Q8IXX2
    Related
    ENSP00000314806.3, ENST00000317011.8
    Conserved Domains (1) summary
    pfam00250
    Location:173261
    Forkhead; Forkhead domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    118971761..118981287
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017575.2XP_016873064.1  forkhead box protein R1 isoform X1

  2. XM_017017576.2XP_016873065.1  forkhead box protein R1 isoform X2

  3. XM_047426801.1XP_047282757.1  forkhead box protein R1 isoform X3

    UniProtKB/TrEMBL
    B0YJ16
    Related
    ENSP00000432358.1, ENST00000533282.1

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_009646203.1 Reference GRCh38.p14 PATCHES

    Range
    382..2887
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    118992171..119001685
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)