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IFNL1 interferon lambda 1 [ Homo sapiens (human) ]

Gene ID: 282618, updated on 8-Jul-2021

Summary

Official Symbol
IFNL1provided by HGNC
Official Full Name
interferon lambda 1provided by HGNC
Primary source
HGNC:HGNC:18363
See related
Ensembl:ENSG00000182393 MIM:607403
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IL29; IL-29
Summary
This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 28B (IL28B) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See IFNL1 in Genome Data Viewer
Location:
19q13.2
Exon count:
5
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (39296407..39298673)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (39787047..39789313)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene interferon lambda 4 pseudogene 1 Neighboring gene interferon lambda 2 Neighboring gene leucine rich repeat and fibronectin type III domain containing 1 Neighboring gene glia maturation factor gamma

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 
enables interleukin-28 receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables signaling receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in defense response to virus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in defense response to virus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of T cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of interleukin-13 production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of interleukin-5 production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of memory T cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of type 2 immune response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of MHC class I biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of immune response TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of interferon-gamma production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of receptor signaling pathway via JAK-STAT IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of tyrosine phosphorylation of STAT protein IDA
Inferred from Direct Assay
more info
PubMed 
involved_in receptor signaling pathway via JAK-STAT IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of interleukin-28 receptor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
interferon lambda-1
Names
IFN-lambda-1
cytokine Zcyto21
interleukin 29 (interferon, lambda 1)
interleukin-29

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172140.2NP_742152.1  interferon lambda-1 precursor

    See identical proteins and their annotated locations for NP_742152.1

    Status: REVIEWED

    Source sequence(s)
    AC011445, AY129150
    Consensus CDS
    CCDS12531.1
    UniProtKB/Swiss-Prot
    Q8IU54
    Related
    ENSP00000329991.1, ENST00000333625.3
    Conserved Domains (1) summary
    pfam15177
    Location:31185
    IL28A; Interleukin-28A

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    39296407..39298673
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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