IFNL1 interferon lambda 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: IFNL1provided by HGNC
Official Full Name: interferon lambda 1provided by HGNC
Primary source: HGNC:HGNC:18363
See related: Ensembl:ENSG00000182393 MIM:607403
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: IL29; IL-29
Summary: This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 28B (IL28B) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008]
Expression: Low expression observed in reference dataset See more
Orthologs: all
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Genomic context

Location:: 19q13.2

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
109.20210514	current	GRCh38.p13 (GCF_000001405.39)	19	NC_000019.10 (39296407..39298673)
105.20201022	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (39787047..39789313)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Enhanced serum interferon-lambda 1 interleukin-29 levels in patients with psoriasis vulgaris.
Title: Enhanced serum interferon-lambda 1 interleukin-29 levels in patients with psoriasis vulgaris.
Interleukin-29 and interleukin-28A induce migration of neutrophils in rheumatoid arthritis.
Title: Interleukin-29 and interleukin-28A induce migration of neutrophils in rheumatoid arthritis.
Interleukin-29 regulates T follicular helper cells by repressing BCL6 in rheumatoid arthritis patients.
Title: Interleukin-29 regulates T follicular helper cells by repressing BCL6 in rheumatoid arthritis patients.
IL-29 promoted obesity-induced inflammation and insulin resistance.
Title: IL-29 promoted obesity-induced inflammation and insulin resistance.
Linkage of Lambda Interferons in Protection Against Severe COVID-19.
Title: Linkage of Lambda Interferons in Protection Against Severe COVID-19.
Dendritic cells-derived interferon-lambda1 ameliorated inflammatory bone destruction through inhibiting osteoclastogenesis.
Title: Dendritic cells-derived interferon-λ1 ameliorated inflammatory bone destruction through inhibiting osteoclastogenesis.
Interferon lambda rs368234815 DeltaG/DeltaG is associated with higher CD4(+):CD8(+) T-cell ratio in treated HIV-1 infection.
Title: Interferon lambda rs368234815 ΔG/ΔG is associated with higher CD4<sup>+</sup>:CD8<sup>+</sup> T-cell ratio in treated HIV-1 infection.
Baculovirus Transduction in Mammalian Cells Is Affected by the Production of Type I and III Interferons, Which Is Mediated Mainly by the cGAS-STING Pathway.
Title: Baculovirus Transduction in Mammalian Cells Is Affected by the Production of Type I and III Interferons, Which Is Mediated Mainly by the cGAS-STING Pathway.
Zika Virus Non-Structural Protein NS5 Inhibits the RIG-I Pathway and Interferon Lambda 1 Promoter Activation by Targeting IKK Epsilon.
Title: Zika Virus Non-Structural Protein NS5 Inhibits the RIG-I Pathway and Interferon Lambda 1 Promoter Activation by Targeting IKK Epsilon.
Type III interferons disrupt the lung epithelial barrier upon viral recognition.
Title: Type III interferons disrupt the lung epithelial barrier upon viral recognition.

Submit: New GeneRIF Correction See all GeneRIFs (117)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:482129

NoName (e-PCR)
- UniSTS:481144

NoName (e-PCR)
- UniSTS:486088

Homology

Homologs of the IFNL1 gene: The IFNL1 gene is conserved in chimpanzee, Rhesus monkey, and cow.
Orthologs from Annotation Pipeline: 48 organisms have orthologs with human gene IFNL1
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables interleukin-28 receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables signaling receptor binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in defense response to virus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in defense response to virus	IDA Inferred from Direct Assay more info	PubMed
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in negative regulation of T cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of interleukin-13 production	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of interleukin-5 production	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of memory T cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription, DNA-templated	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of type 2 immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of MHC class I biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of immune response	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of interferon-gamma production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of receptor signaling pathway via JAK-STAT	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription, DNA-templated	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of tyrosine phosphorylation of STAT protein	IDA Inferred from Direct Assay more info	PubMed
involved_in receptor signaling pathway via JAK-STAT	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of interleukin-28 receptor complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: interferon lambda-1

Names: IFN-lambda-1; cytokine Zcyto21; interleukin 29 (interferon, lambda 1); interleukin-29

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.