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IFNL2 interferon lambda 2 [ Homo sapiens (human) ]

Gene ID: 282616, updated on 23-Nov-2021

Summary

Official Symbol
IFNL2provided by HGNC
Official Full Name
interferon lambda 2provided by HGNC
Primary source
HGNC:HGNC:18364
See related
Ensembl:ENSG00000183709 MIM:607401
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IL28A; IFNL2a; IFNL3a; IL-28A
Summary
This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28B (IL28B), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
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Genomic context

See IFNL2 in Genome Data Viewer
Location:
19q13.2
Exon count:
6
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (39268396..39270188)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (39759036..39760828)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr19.4063 Neighboring gene interferon lambda 4 pseudogene 1 Neighboring gene interferon lambda 1 Neighboring gene leucine rich repeat and fibronectin type III domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in defense response to virus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in defense response to virus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mucosal immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in receptor signaling pathway via JAK-STAT IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
interferon lambda-2
Names
IFN-lambda-2
cytokine Zcyto20
interleukin 28A (interferon, lambda 2)
interleukin-28A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172138.2NP_742150.1  interferon lambda-2 precursor

    See identical proteins and their annotated locations for NP_742150.1

    Status: VALIDATED

    Source sequence(s)
    AA774195, AC011445, AY129148
    Consensus CDS
    CCDS42567.1
    UniProtKB/Swiss-Prot
    Q8IZJ0
    Related
    ENSP00000333639.5, ENST00000331982.6
    Conserved Domains (1) summary
    pfam15177
    Location:38191
    IL28A; Interleukin-28A

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    39268396..39270188
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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