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Selenoi selenoprotein I [ Mus musculus (house mouse) ]

Gene ID: 28042, updated on 17-Jun-2024

Summary

Official Symbol
Selenoiprovided by MGI
Official Full Name
selenoprotein Iprovided by MGI
Primary source
MGI:MGI:107898
See related
Ensembl:ENSMUSG00000075703 AllianceGenome:MGI:107898
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ept1; SELI; D5Wsu178e; mKIAA1724; 4933402G07Rik
Summary
The multi-pass transmembrane protein encoded by this gene belongs to the CDP-alcohol phosphatidyltransferase class-I family. It catalyzes the transfer of phosphoethanolamine from CDP-ethanolamine to diacylglycerol to produce phosphatidylethanolamine, which is involved in the formation and maintenance of vesicular membranes, regulation of lipid metabolism, and protein folding. This protein is a selenoprotein, containing the rare selenocysteine (Sec) amino acid at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2016]
Expression
Ubiquitous expression in CNS E18 (RPKM 9.7), large intestine adult (RPKM 8.8) and 28 other tissues See more
Orthologs
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Genomic context

See Selenoi in Genome Data Viewer
Location:
5 B1; 5 16.22 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (30437579..30477428)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (30232581..30272430)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta Neighboring gene microRNA 1960 Neighboring gene adhesion G protein-coupled receptor F3 Neighboring gene STARR-positive B cell enhancer ABC_E1678 Neighboring gene predicted gene, 54326 Neighboring gene predicted gene 16288 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:30645501-30645684 Neighboring gene dynein regulatory complex subunit 1 Neighboring gene otoferlin

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4)  1 citation
  • Gene trapped (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC117838

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ethanolaminephosphotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ethanolaminephosphotransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphotransferase activity, for other substituted phosphate groups IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in phosphatidylethanolamine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in phosphatidylethanolamine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ethanolaminephosphotransferase 1
Names
ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)
NP_081928.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027652.3NP_081928.2  ethanolaminephosphotransferase 1

    See identical proteins and their annotated locations for NP_081928.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the selenoprotein encoding transcript.
    Source sequence(s)
    AC241618, AK122544, AK133635, BC078438, BY136287
    Consensus CDS
    CCDS51451.1
    UniProtKB/Swiss-Prot
    Q3KQQ5, Q80TA1, Q8BG08
    Related
    ENSMUSP00000118368.3, ENSMUST00000145167.9
    Conserved Domains (1) summary
    cl00453
    Location:6312
    CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase

RNA

  1. NR_137634.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an internal exon and uses an alternate donor splice site at another internal exon compared to variant 1. It is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC241618, AK014530, AK122544, AK133635, BC078438, BY136287

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    30437579..30477428
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)