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AMY2B amylase alpha 2B [ Homo sapiens (human) ]

Gene ID: 280, updated on 23-Nov-2021

Summary

Official Symbol
AMY2Bprovided by HGNC
Official Full Name
amylase alpha 2Bprovided by HGNC
Primary source
HGNC:HGNC:478
See related
Ensembl:ENSG00000240038 MIM:104660
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HXA; AMY2; AMY3
Summary
Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the pancreas. [provided by RefSeq, Jun 2013]
Expression
Biased expression in pancreas (RPKM 6104.1) and salivary gland (RPKM 774.6) See more
Orthologs
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Genomic context

See AMY2B in Genome Data Viewer
Location:
1p21.1
Exon count:
13
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (103554644..103579534)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (104097266..104122156)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene collagen type XI alpha 1 chain Neighboring gene superoxide dismutase 2 pseudogene 1 Neighboring gene RNPC3 divergent transcript Neighboring gene RN7SK pseudogene 285 Neighboring gene RNA binding region (RNP1, RRM) containing 3 Neighboring gene actin gamma 1 pseudogene 4 Neighboring gene amylase alpha 2A Neighboring gene amylase alpha 1A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: RNPC3

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables alpha-amylase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables alpha-amylase activity (releasing maltohexaose) IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 

General protein information

Preferred Names
alpha-amylase 2B
Names
1,4-alpha-D-glucan glucanohydrolase 2B
amylase alpha 2B (pancreatic)
carcinoid alpha-amylase
glycogenase
NP_001373038.1
NP_001374366.1
NP_066188.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001386109.1NP_001373038.1  alpha-amylase 2B precursor

    Status: REVIEWED

    Source sequence(s)
    AC105272
    Conserved Domains (3) summary
    cd11317
    Location:25416
    AmyAc_bac_euk_AmyA; Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase)
    smart00632
    Location:422510
    Aamy_C; Aamy_C domain
    PLN02447
    Location:85155
    PLN02447; 1,4-alpha-glucan-branching enzyme
  2. NM_001387437.1NP_001374366.1  alpha-amylase 2B precursor

    Status: REVIEWED

    Source sequence(s)
    AC105272
    Related
    ENSP00000507176.1, ENST00000684275.1
    Conserved Domains (3) summary
    cd11317
    Location:25416
    AmyAc_bac_euk_AmyA; Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase)
    smart00632
    Location:422510
    Aamy_C; Aamy_C domain
    PLN02447
    Location:85155
    PLN02447; 1,4-alpha-glucan-branching enzyme
  3. NM_020978.4NP_066188.1  alpha-amylase 2B precursor

    See identical proteins and their annotated locations for NP_066188.1

    Status: REVIEWED

    Source sequence(s)
    AI436349, BC011179, DA157436, DB235608
    Consensus CDS
    CCDS782.1
    UniProtKB/Swiss-Prot
    P19961
    Related
    ENSP00000354610.4, ENST00000361355.8
    Conserved Domains (3) summary
    cd11317
    Location:25416
    AmyAc_bac_euk_AmyA; Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase)
    smart00632
    Location:422510
    Aamy_C; Aamy_C domain
    PLN02447
    Location:85155
    PLN02447; 1,4-alpha-glucan-branching enzyme

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    103554644..103579534
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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