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GNL1 G protein nucleolar 1 (putative) [ Homo sapiens (human) ]

Gene ID: 2794, updated on 1-Jun-2020

Summary

Official Symbol
GNL1provided by HGNC
Official Full Name
G protein nucleolar 1 (putative)provided by HGNC
Primary source
HGNC:HGNC:4413
See related
Ensembl:ENSG00000204590 MIM:143024
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSR1
Summary
The GNL1 gene, identified in the human major histocompatibility complex class I region, shows a high degree of similarity with its mouse counterpart. The GNL1 gene is located less than 2 kb centromeric to HLA-E, in the same transcriptional orientation. GNL1 is telomeric to HLA-B and HLA-C. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 17.9), testis (RPKM 13.8) and 25 other tissues See more
Orthologs

Genomic context

See GNL1 in Genome Data Viewer
Location:
6p21.33
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (30541377..30557594, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (30509154..30525371, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene major histocompatibility complex, class I, E Neighboring gene long intergenic non-protein coding RNA 2569 Neighboring gene proline rich 3 Neighboring gene ABCF1 divergent transcript Neighboring gene ATP binding cassette subfamily F member 1 Neighboring gene microRNA 877

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ37752, DKFZp547E038, DKFZp547E128

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding NAS
Non-traceable Author Statement
more info
PubMed 
GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
structural molecule activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
T cell mediated immunity NAS
Non-traceable Author Statement
more info
PubMed 
cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
extracellular space NAS
Non-traceable Author Statement
more info
PubMed 
nucleus HDA PubMed 

General protein information

Preferred Names
guanine nucleotide-binding protein-like 1
Names
GTP-binding protein HSR1
HSR1 GTP-binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005275.3NP_005266.2  guanine nucleotide-binding protein-like 1

    See identical proteins and their annotated locations for NP_005266.2

    Status: VALIDATED

    Source sequence(s)
    AI433804, AK302480, AL662800, BC018366, BQ188153, DA044212
    Consensus CDS
    CCDS4680.1
    UniProtKB/Swiss-Prot
    P36915
    UniProtKB/TrEMBL
    A0A024RCR2, B4DYK6
    Related
    ENSP00000365806.3, ENST00000376621.7
    Conserved Domains (2) summary
    cd01857
    Location:177418
    HSR1_MMR1; A circularly permuted subfamily of the Ras GTPases
    cl26335
    Location:170514
    RbgA; Ribosome biogenesis GTPase A [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    30541377..30557594 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005249015.4XP_005249072.1  guanine nucleotide-binding protein-like 1 isoform X1

    See identical proteins and their annotated locations for XP_005249072.1

    UniProtKB/Swiss-Prot
    P36915
    UniProtKB/TrEMBL
    A0A024RCR2
    Conserved Domains (2) summary
    cd01857
    Location:177418
    HSR1_MMR1; A circularly permuted subfamily of the Ras GTPases
    cl26335
    Location:170514
    RbgA; Ribosome biogenesis GTPase A [Translation, ribosomal structure and biogenesis]

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_167244.2 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    1870881..1883062 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_2

Genomic

  1. NT_113891.3 Reference GRCh38.p13 ALT_REF_LOCI_2

    Range
    2021096..2037314 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_3

Genomic

  1. NT_167245.2 Reference GRCh38.p13 ALT_REF_LOCI_3

    Range
    1797200..1813418 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_4

Genomic

  1. NT_167246.2 Reference GRCh38.p13 ALT_REF_LOCI_4

    Range
    1851606..1867823 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_5

Genomic

  1. NT_167247.2 Reference GRCh38.p13 ALT_REF_LOCI_5

    Range
    1885423..1901640 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_6

Genomic

  1. NT_167248.2 Reference GRCh38.p13 ALT_REF_LOCI_6

    Range
    1796461..1812679 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_7

Genomic

  1. NT_167249.2 Reference GRCh38.p13 ALT_REF_LOCI_7

    Range
    1842133..1858349 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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