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GNG11 G protein subunit gamma 11 [ Homo sapiens (human) ]

Gene ID: 2791, updated on 13-Mar-2020

Summary

Official Symbol
GNG11provided by HGNC
Official Full Name
G protein subunit gamma 11provided by HGNC
Primary source
HGNC:HGNC:4403
See related
Ensembl:ENSG00000127920 MIM:604390
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GNGT11
Summary
This gene is a member of the guanine nucleotide-binding protein (G protein) gamma family and encodes a lipid-anchored, cell membrane protein. As a member of the heterotrimeric G protein complex, this protein plays a role in this transmembrane signaling system. This protein is also subject to carboxyl-terminal processing. Decreased expression of this gene is associated with splenic marginal zone lymphomas. [provided by RefSeq, Jul 2008]
Expression
Broad expression in fat (RPKM 168.6), placenta (RPKM 159.2) and 18 other tissues See more
Orthologs

Genomic context

See GNG11 in Genome Data Viewer
Location:
7q21.3
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (93921735..93928610)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (93551016..93555826)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene TFPI2 divergent transcript Neighboring gene uncharacterized LOC105375402 Neighboring gene G protein subunit gamma transducin 1 Neighboring gene BET1 antisense RNA 1 Neighboring gene Bet1 golgi vesicular membrane trafficking protein Neighboring gene uncharacterized LOC107986820

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G-protein beta-subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
G-protein beta/gamma-subunit complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heterotrimeric G-protein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
Names
G protein gamma-11 subunit
guanine nucleotide binding protein (G protein), gamma 11
guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-11 subunit

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004126.4NP_004117.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 precursor

    See identical proteins and their annotated locations for NP_004117.1

    Status: REVIEWED

    Source sequence(s)
    AC002076, BC009709
    Consensus CDS
    CCDS5634.1
    UniProtKB/Swiss-Prot
    P61952
    UniProtKB/TrEMBL
    Q53Y01
    Related
    ENSP00000248564.4, ENST00000248564.6
    Conserved Domains (1) summary
    smart00224
    Location:1273
    GGL; G protein gamma subunit-like motifs

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    93921735..93928610
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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