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AMY1B amylase alpha 1B [ Homo sapiens (human) ]

Gene ID: 277, updated on 3-May-2025
Official Symbol
AMY1Bprovided by HGNC
Official Full Name
amylase alpha 1Bprovided by HGNC
Primary source
HGNC:HGNC:475
See related
Ensembl:ENSG00000174876 MIM:104701; AllianceGenome:HGNC:475
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AMY1
Summary
Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the salivary gland. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward salivary gland (RPKM 4863.3) See more
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See AMY1B in Genome Data Viewer
Location:
1p21.1
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (103687415..103696453, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (103536281..103545319, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (104230037..104239075, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene amylase alpha 1A Neighboring gene uncharacterized LOC124904594 Neighboring gene uncharacterized LOC105378878 Neighboring gene amylase alpha pseudogene 1

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • MGC177995

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables alpha-amylase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables alpha-amylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables alpha-amylase activity IEA
Inferred from Electronic Annotation
more info
 
enables amylase activity IEA
Inferred from Electronic Annotation
more info
 
enables calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables cation binding IEA
Inferred from Electronic Annotation
more info
 
enables chloride ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in oligosaccharide metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
alpha-amylase 1B
Names
1,4-alpha-D-glucan glucanohydrolase 1
alpha-amylase 1
alpha-amylase 1A
amylase alpha 1B (salivary)
amylase, salivary, alpha-1B
glycogenase
salivary alpha-amylase
salivary amylase alpha 1B
NP_001008219.1
NP_001373854.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008218.2NP_001008219.1  alpha-amylase 1B precursor

    See identical proteins and their annotated locations for NP_001008219.1

    Status: REVIEWED

    Source sequence(s)
    AL513482
    Consensus CDS
    CCDS30783.1
    UniProtKB/Swiss-Prot
    A6NJS5, A8K8H6, P04745, P0DTE7, P0DTE8, P0DUB6, Q13763, Q5T083
    UniProtKB/TrEMBL
    B7ZMD7
    Related
    ENSP00000330484.5, ENST00000330330.10
    Conserved Domains (2) summary
    cd11317
    Location:25416
    AmyAc_bac_euk_AmyA; Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase)
    smart00632
    Location:422510
    Aamy_C; Aamy_C domain
  2. NM_001386925.1NP_001373854.1  alpha-amylase 1B precursor

    Status: REVIEWED

    Source sequence(s)
    AL513482
    Consensus CDS
    CCDS30783.1
    UniProtKB/Swiss-Prot
    A6NJS5, A8K8H6, P04745, P0DTE7, P0DTE8, P0DUB6, Q13763, Q5T083
    UniProtKB/TrEMBL
    B7ZMD7
    Related
    ENSP00000359097.3, ENST00000370080.7
    Conserved Domains (2) summary
    cd11317
    Location:25416
    AmyAc_bac_euk_AmyA; Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase)
    smart00632
    Location:422510
    Aamy_C; Aamy_C domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    103687415..103696453 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    103536281..103545319 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)