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AMY1B amylase alpha 1B [ Homo sapiens (human) ]

Gene ID: 277, updated on 5-Aug-2022

Summary

Official Symbol
AMY1Bprovided by HGNC
Official Full Name
amylase alpha 1Bprovided by HGNC
Primary source
HGNC:HGNC:475
See related
Ensembl:ENSG00000174876 MIM:104701; AllianceGenome:HGNC:475
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AMY1
Summary
Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the salivary gland. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward salivary gland (RPKM 4863.3) See more
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Genomic context

See AMY1B in Genome Data Viewer
Location:
1p21.1
Exon count:
12
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (103687415..103696453, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (103630427..103639463, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (104230037..104239075, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene amylase alpha 1A Neighboring gene uncharacterized LOC124904594 Neighboring gene uncharacterized LOC105378878 Neighboring gene amylase alpha pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
alpha-amylase 1B
Names
1,4-alpha-D-glucan glucanohydrolase 1
alpha-amylase 1
alpha-amylase 1A
amylase alpha 1B (salivary)
amylase, salivary, alpha-1B
glycogenase
salivary alpha-amylase
salivary amylase alpha 1B
NP_001008219.1
NP_001373854.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008218.2NP_001008219.1  alpha-amylase 1B precursor

    See identical proteins and their annotated locations for NP_001008219.1

    Status: REVIEWED

    Source sequence(s)
    AL513482
    Consensus CDS
    CCDS30783.1
    UniProtKB/Swiss-Prot
    P04745, Q5T083
    Related
    ENSP00000330484.5, ENST00000330330.10
    Conserved Domains (2) summary
    cd11317
    Location:25416
    AmyAc_bac_euk_AmyA; Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase)
    smart00632
    Location:422510
    Aamy_C; Aamy_C domain
  2. NM_001386925.1NP_001373854.1  alpha-amylase 1B precursor

    Status: REVIEWED

    Source sequence(s)
    AL513482
    UniProtKB/Swiss-Prot
    Q5T083
    Related
    ENSP00000359097.3, ENST00000370080.7
    Conserved Domains (2) summary
    cd11317
    Location:25416
    AmyAc_bac_euk_AmyA; Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase)
    smart00632
    Location:422510
    Aamy_C; Aamy_C domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    103687415..103696453 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    103630427..103639463 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)