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GMFB glia maturation factor beta [ Homo sapiens (human) ]

Gene ID: 2764, updated on 6-May-2021

Summary

Official Symbol
GMFBprovided by HGNC
Official Full Name
glia maturation factor betaprovided by HGNC
Primary source
HGNC:HGNC:4373
See related
Ensembl:ENSG00000197045 MIM:601713
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GMF
Expression
Ubiquitous expression in brain (RPKM 45.0), colon (RPKM 21.0) and 24 other tissues See more
Orthologs
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Genomic context

See GMFB in Genome Data Viewer
Location:
14q22.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (54474485..54488980, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (54941203..54955698, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene cyclin dependent kinase inhibitor 3 Neighboring gene cornichon family AMPA receptor auxiliary protein 1 Neighboring gene cell growth regulator with ring finger domain 1 Neighboring gene sterile alpha motif domain containing 4A Neighboring gene uncharacterized LOC112268133

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association scan of dental caries in the permanent dentition.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables Arp2/3 complex binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables enzyme activator activity TAS
Traceable Author Statement
more info
PubMed 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase inhibitor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in actin filament debranching IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of Arp2/3 complex-mediated actin nucleation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in nervous system development TAS
Traceable Author Statement
more info
PubMed 
involved_in protein phosphorylation TAS
Traceable Author Statement
more info
PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in actin cortical patch IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
glia maturation factor beta
Names
GMF-beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004124.3NP_004115.1  glia maturation factor beta

    See identical proteins and their annotated locations for NP_004115.1

    Status: VALIDATED

    Source sequence(s)
    AB001106, AI342496, AL359792, BG622077, BI547506
    Consensus CDS
    CCDS9718.1
    UniProtKB/Swiss-Prot
    P60983
    Related
    ENSP00000350757.3, ENST00000358056.8
    Conserved Domains (1) summary
    cd11283
    Location:9130
    ADF_GMF-beta_like; ADF-homology domain of glia maturation factor beta and related proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    54474485..54488980 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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