U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Sergef secretion regulating guanine nucleotide exchange factor [ Mus musculus (house mouse) ]

Gene ID: 27414, updated on 7-Apr-2025

Summary

Go to the top of the page Help
Official Symbol
Sergefprovided by MGI
Official Full Name
secretion regulating guanine nucleotide exchange factorprovided by MGI
Primary source
MGI:MGI:1351630
See related
Ensembl:ENSMUSG00000030839 AllianceGenome:MGI:1351630
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gef; Gnef; Gnefr; DelGEF
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in negative regulation of protein secretion. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in central nervous system; esophagus; and ganglia. Orthologous to human SERGEF (secretion regulating guanine nucleotide exchange factor). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Ubiquitous expression in CNS E18 (RPKM 6.3), frontal lobe adult (RPKM 5.1) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Sergef in Genome Data Viewer
Location:
7 B3; 7 30.2 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (46092583..46289254, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (46443159..46642896, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9691 Neighboring gene myogenic differentiation 1 Neighboring gene STARR-positive B cell enhancer ABC_E4927 Neighboring gene potassium voltage gated channel, Shaw-related subfamily, member 1 Neighboring gene predicted gene, 22969 Neighboring gene STARR-seq mESC enhancer starr_18863 Neighboring gene STARR-seq mESC enhancer starr_18865 Neighboring gene STARR-seq mESC enhancer starr_18866 Neighboring gene STARR-seq mESC enhancer starr_18867 Neighboring gene tryptophan hydroxylase 1 Neighboring gene serum amyloid A-like 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Rac1 Activation Caused by Membrane Translocation of a Guanine Nucleotide Exchange Factor in Akt2-Mediated Insulin Signaling in Mouse Skeletal Muscle. Takenaka N, et al. PLoS One, 2016. PMID 27163697, Free PMC Article
  2. DelGEF, an RCC1-related protein encoded by a gene on chromosome 11p14 critical for two forms of hereditary deafness. Uhlmann J, et al. FEBS Lett, 1999 Oct 22. PMID 10571079
  3. Ru2 and Ru encode mouse orthologs of the genes mutated in human Hermansky-Pudlak syndrome types 5 and 6. Zhang Q, et al. Nat Genet, 2003 Feb. PMID 12548288
  4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rac1 activation is caused by membrane translocation of a guanine nucleotide exchange factor FLJ00068 in Akt2-mediated insulin signaling in mouse skeletal muscle.
    Title: Rac1 Activation Caused by Membrane Translocation of a Guanine Nucleotide Exchange Factor in Akt2-Mediated Insulin Signaling in Mouse Skeletal Muscle.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC141208, MGC141209

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in negative regulation of protein secretion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of protein secretion IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
secretion-regulating guanine nucleotide exchange factor
Names
deafness locus-associated putative guanine nucleotide exchange factor
guanine nucleotide exchange factor (RCC1 related)
guanine nucleotide exchange factor-related protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013789.2 → NP_038817.1  secretion-regulating guanine nucleotide exchange factor

    See identical proteins and their annotated locations for NP_038817.1

    Status: VALIDATED

    Source sequence(s)
    AC090652, AK145819, BY228093
    Consensus CDS
    CCDS21279.1
    UniProtKB/Swiss-Prot
    Q0VDT0, Q3UGM8, Q3UKY0, Q80YD6, Q9QXB7
    Related
    ENSMUSP00000033127.5, ENSMUST00000033127.12
    Conserved Domains (2) summary
    pfam00415
    Location:17 → 64
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam13540
    Location:103 → 132
    RCC1_2; Regulator of chromosome condensation (RCC1) repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    46092583..46289254 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153151.1 → XP_036009044.1  secretion-regulating guanine nucleotide exchange factor isoform X2

    Conserved Domains (2) summary
    COG5184
    Location:17 → 348
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    pfam00415
    Location:334 → 380
    RCC1; Regulator of chromosome condensation (RCC1) repeat

  2. XM_030242640.2 → XP_030098500.1  secretion-regulating guanine nucleotide exchange factor isoform X8

    Conserved Domains (1) summary
    COG5184
    Location:17 → 279
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

  3. XM_006540943.5 → XP_006541006.1  secretion-regulating guanine nucleotide exchange factor isoform X1

    Conserved Domains (2) summary
    COG5184
    Location:22 → 370
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    pfam00415
    Location:356 → 402
    RCC1; Regulator of chromosome condensation (RCC1) repeat

  4. XM_011250869.2 → XP_011249171.1  secretion-regulating guanine nucleotide exchange factor isoform X5

    See identical proteins and their annotated locations for XP_011249171.1

    Conserved Domains (2) summary
    COG5184
    Location:2 → 255
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    pfam00415
    Location:241 → 287
    RCC1; Regulator of chromosome condensation (RCC1) repeat

  5. XM_006540944.4 → XP_006541007.1  secretion-regulating guanine nucleotide exchange factor isoform X5

    See identical proteins and their annotated locations for XP_006541007.1

    Conserved Domains (2) summary
    COG5184
    Location:2 → 255
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    pfam00415
    Location:241 → 287
    RCC1; Regulator of chromosome condensation (RCC1) repeat

  6. XM_030242642.2 → XP_030098502.1  secretion-regulating guanine nucleotide exchange factor isoform X10

    Conserved Domains (1) summary
    COG5184
    Location:17 → 258
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

  7. XM_036153152.1 → XP_036009045.1  secretion-regulating guanine nucleotide exchange factor isoform X4

    Conserved Domains (1) summary
    COG5184
    Location:17 → 327
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

  8. XM_030242641.2 → XP_030098501.1  secretion-regulating guanine nucleotide exchange factor isoform X9

    Conserved Domains (1) summary
    COG5184
    Location:17 → 279
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

  9. XM_030242638.2 → XP_030098498.1  secretion-regulating guanine nucleotide exchange factor isoform X3

    UniProtKB/TrEMBL
    A0A1L1SUM5
    Related
    ENSMUSP00000150835.2, ENSMUST00000216505.2
    Conserved Domains (1) summary
    COG5184
    Location:17 → 348
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

  10. XM_036153153.1 → XP_036009046.1  secretion-regulating guanine nucleotide exchange factor isoform X7

    Conserved Domains (1) summary
    COG5184
    Location:17 → 258
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

  11. XM_030242639.2 → XP_030098499.1  secretion-regulating guanine nucleotide exchange factor isoform X6

    Conserved Domains (1) summary
    COG5184
    Location:17 → 279
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

RNA

  1. XR_003946486.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80YD6.2 GenPept UniProtKB/Swiss-Prot:Q80YD6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools