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GLP1R glucagon like peptide 1 receptor [ Homo sapiens (human) ]

Gene ID: 2740, updated on 24-Dec-2019

Summary

Official Symbol
GLP1Rprovided by HGNC
Official Full Name
glucagon like peptide 1 receptorprovided by HGNC
Primary source
HGNC:HGNC:4324
See related
Ensembl:ENSG00000112164 MIM:138032
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GLP-1; GLP-1R; GLP-1-R
Summary
This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016]
Expression
Biased expression in heart (RPKM 1.0), brain (RPKM 1.0) and 10 other tissues See more
Orthologs

Genomic context

See GLP1R in Genome Data Viewer
Location:
6p21.2
Exon count:
14
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (39048781..39091303)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (39016557..39056657)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene dynein axonemal heavy chain 8 Neighboring gene DNAH8 antisense RNA 1 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene uncharacterized LOC105375046 Neighboring gene microRNA 9983 Neighboring gene ankyrin repeat domain 18E, pseudogene Neighboring gene SAYSVFN motif domain containing 1 Neighboring gene potassium two pore domain channel subfamily K member 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC138331

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glucagon receptor activity IEA
Inferred from Electronic Annotation
more info
 
glucagon-like peptide 1 receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
peptide hormone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transmembrane signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
activation of adenylate cyclase activity TAS
Traceable Author Statement
more info
PubMed 
adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
cAMP-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cellular response to glucagon stimulus IEA
Inferred from Electronic Annotation
more info
 
learning or memory IEA
Inferred from Electronic Annotation
more info
 
positive regulation of blood pressure IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cytosolic calcium ion concentration IDA
Inferred from Direct Assay
more info
PubMed 
regulation of heart contraction IEA
Inferred from Electronic Annotation
more info
 
regulation of insulin secretion TAS
Traceable Author Statement
more info
 
response to psychosocial stress IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
glucagon-like peptide 1 receptor
Names
GLP-1 receptor
GLP1 receptor
seven transmembrane helix receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002062.5NP_002053.3  glucagon-like peptide 1 receptor precursor

    See identical proteins and their annotated locations for NP_002053.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the supported protein.
    Source sequence(s)
    AL035690, BC113493, CK819862, KR138540
    Consensus CDS
    CCDS4839.1
    UniProtKB/Swiss-Prot
    P43220
    UniProtKB/TrEMBL
    A0A142FHB8
    Related
    ENSP00000362353.4, ENST00000373256.5
    Conserved Domains (2) summary
    pfam00002
    Location:144398
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:60128
    HRM; Hormone receptor domain

RNA

  1. NR_136562.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) splices out a segment of the 3' terminal exon, compared to variant 1. This variant is represented as non-coding because the use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL035690, BC113493, CK819862, KR138540, U10037
  2. NR_136563.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) splices out a segment of the 3' terminal exon, compared to variant 1. This variant is represented as non-coding because the use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL035690, BC113493, CK819862, KR138540, U01156

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    39048781..39091303
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017010751.1XP_016866240.1  glucagon-like peptide 1 receptor isoform X2

  2. XM_017010750.1XP_016866239.1  glucagon-like peptide 1 receptor isoform X1

RNA

  1. XR_001743346.1 RNA Sequence

  2. XR_001743347.1 RNA Sequence

  3. XR_001743348.1 RNA Sequence

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