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Srr serine racemase [ Mus musculus (house mouse) ]

Gene ID: 27364, updated on 12-May-2024

Summary

Official Symbol
Srrprovided by MGI
Official Full Name
serine racemaseprovided by MGI
Primary source
MGI:MGI:1351636
See related
Ensembl:ENSMUSG00000001323 AllianceGenome:MGI:1351636
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Srs; Rgsc34; M100034
Summary
Enables several functions, including amino-acid racemase activity; anion binding activity; and identical protein binding activity. Acts upstream of or within D-serine biosynthetic process and L-serine metabolic process. Predicted to be located in apical part of cell; neuronal cell body; and plasma membrane. Predicted to be active in cytoplasm. Is expressed in facial bone primordium and nervous system. Used to study schizophrenia. Orthologous to human SRR (serine racemase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in frontal lobe adult (RPKM 12.8), cortex adult (RPKM 12.1) and 28 other tissues See more
Orthologs
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Genomic context

See Srr in Genome Data Viewer
Location:
11 B5; 11 45.76 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (74794853..74818427, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (74904027..74927533, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7015 Neighboring gene max binding protein Neighboring gene small G protein signaling modulator 2 Neighboring gene microRNA 6926 Neighboring gene small nucleolar RNA, C/D box 91A Neighboring gene TSR1 20S rRNA accumulation Neighboring gene STARR-seq mESC enhancer starr_29979 Neighboring gene predicted gene, 22733 Neighboring gene SMG6 nonsense mediated mRNA decay factor Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:74826503-74826738 Neighboring gene SMT3 suppressor of mif two 3 homolog 2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (9)  1 citation
  • Endonuclease-mediated (1) 
  • Gene trapped (2) 
  • Targeted (7)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables D-serine ammonia-lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables L-serine ammonia-lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables L-serine ammonia-lyase activity ISO
Inferred from Sequence Orthology
more info
 
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables glycine binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables pyridoxal phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables pyridoxal phosphate binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables pyridoxal phosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables serine racemase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables serine racemase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables serine racemase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables threonine racemase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables threonine racemase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in apical part of cell ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
serine racemase
Names
D-serine ammonia-lyase
D-serine dehydratase
L-serine ammonia-lyase
L-serine dehydratase
NP_001156783.1
NP_001349671.1
NP_001349672.1
NP_001349673.1
NP_038789.1
XP_006533520.1
XP_011247359.1
XP_017170060.1
XP_030101905.1
XP_030101906.1
XP_036012631.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163311.2NP_001156783.1  serine racemase isoform 1

    See identical proteins and their annotated locations for NP_001156783.1

    Status: VALIDATED

    Source sequence(s)
    AB232342, AK043738, AK079343, AL604066, BY475189
    Consensus CDS
    CCDS25038.1
    UniProtKB/Swiss-Prot
    Q401M7, Q5SWE4, Q5SWE5, Q5SWE7, Q8BT19, Q8CD11, Q9QZX7
    Related
    ENSMUSP00000113372.2, ENSMUST00000121738.8
    Conserved Domains (1) summary
    cl00342
    Location:5322
    Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...
  2. NM_001362742.1NP_001349671.1  serine racemase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK031687, AL604066
    Consensus CDS
    CCDS88190.1
    Related
    ENSMUSP00000104086.2, ENSMUST00000108447.8
    Conserved Domains (1) summary
    cl00342
    Location:5297
    Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...
  3. NM_001362743.1NP_001349672.1  serine racemase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL604066
    Conserved Domains (1) summary
    cl00342
    Location:5267
    Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...
  4. NM_001362744.1NP_001349673.1  serine racemase isoform 4

    Status: VALIDATED

    Source sequence(s)
    AK079343, AL604066
    Conserved Domains (1) summary
    cl00342
    Location:1180
    Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...
  5. NM_013761.5NP_038789.1  serine racemase isoform 1

    See identical proteins and their annotated locations for NP_038789.1

    Status: VALIDATED

    Source sequence(s)
    AB232342, AK043738, AK079343, AL604066, BY475189
    Consensus CDS
    CCDS25038.1
    UniProtKB/Swiss-Prot
    Q401M7, Q5SWE4, Q5SWE5, Q5SWE7, Q8BT19, Q8CD11, Q9QZX7
    Related
    ENSMUSP00000067552.3, ENSMUST00000065211.9
    Conserved Domains (1) summary
    cl00342
    Location:5322
    Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    74794853..74818427 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011249057.4XP_011247359.1  serine racemase isoform X2

    Conserved Domains (1) summary
    cl00342
    Location:5267
    Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...
  2. XM_036156738.1XP_036012631.1  serine racemase isoform X2

    Conserved Domains (1) summary
    cl00342
    Location:5267
    Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...
  3. XM_017314571.3XP_017170060.1  serine racemase isoform X3

    UniProtKB/Swiss-Prot
    Q401M7, Q5SWE4, Q5SWE5, Q5SWE7, Q8BT19, Q8CD11, Q9QZX7
    Conserved Domains (1) summary
    cl00342
    Location:5322
    Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...
  4. XM_006533457.5XP_006533520.1  serine racemase isoform X3

    See identical proteins and their annotated locations for XP_006533520.1

    UniProtKB/Swiss-Prot
    Q401M7, Q5SWE4, Q5SWE5, Q5SWE7, Q8BT19, Q8CD11, Q9QZX7
    Conserved Domains (1) summary
    cl00342
    Location:5322
    Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...
  5. XM_030246045.2XP_030101905.1  serine racemase isoform X1

    Conserved Domains (1) summary
    cl00342
    Location:5267
    Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...
  6. XM_030246046.2XP_030101906.1  serine racemase isoform X2

    Conserved Domains (1) summary
    cl00342
    Location:5267
    Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...