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Add3 adducin 3 [ Mus musculus (house mouse) ]

Gene ID: 27360, updated on 3-Apr-2024

Summary

Official Symbol
Add3provided by MGI
Official Full Name
adducin 3provided by MGI
Primary source
MGI:MGI:1351615
See related
Ensembl:ENSMUSG00000025026 AllianceGenome:MGI:1351615
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
A structural constituent of cytoskeleton. Predicted to be involved in barbed-end actin filament capping; positive regulation of vasoconstriction; and response to xenobiotic stimulus. Located in several cellular components, including brush border; condensed nuclear chromosome; and postsynaptic density. Is expressed in central nervous system; chondrocranium; gut; tail unsegmented mesenchyme; and vertebral axis musculature. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 50. Orthologous to human ADD3 (adducin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 34.1), cerebellum adult (RPKM 18.5) and 27 other tissues See more
Orthologs
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Genomic context

Location:
19 D2; 19 47.18 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (53128874..53235518)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (53140443..53247326)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30381 Neighboring gene STARR-positive B cell enhancer ABC_E7672 Neighboring gene STARR-positive B cell enhancer ABC_E782 Neighboring gene predicted gene 9618 Neighboring gene STARR-positive B cell enhancer mm9_chr19:53260109-53260409 Neighboring gene STARR-seq mESC enhancer starr_46440 Neighboring gene predicted gene, 52402 Neighboring gene RIKEN cDNA 1700001K23 gene Neighboring gene predicted gene, 36339

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase C binding ISO
Inferred from Sequence Orthology
more info
 
enables structural constituent of cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in barbed-end actin filament capping IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vasoconstriction ISO
Inferred from Sequence Orthology
more info
 
involved_in response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in brush border IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in condensed nuclear chromosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
gamma-adducin
Names
adducin 3 (gamma)
adducin-like protein 70
cytoskeletal protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164099.3NP_001157571.1  gamma-adducin isoform a

    See identical proteins and their annotated locations for NP_001157571.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1, 2, and 5 encode the same isoform (a).
    Source sequence(s)
    AC138174
    Consensus CDS
    CCDS29900.1
    UniProtKB/Swiss-Prot
    Q8JZT6, Q9D2M5, Q9QYB5, Q9QYB6
    UniProtKB/TrEMBL
    Q05C56
    Related
    ENSMUSP00000158149.2, ENSMUST00000237301.2
    Conserved Domains (1) summary
    cl00214
    Location:137385
    Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
  2. NM_001164100.3NP_001157572.1  gamma-adducin isoform b

    See identical proteins and their annotated locations for NP_001157572.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a. Both variants 3 and 4 encode the same isoform (b).
    Source sequence(s)
    AC138174
    Consensus CDS
    CCDS50467.1
    UniProtKB/TrEMBL
    Q3UNK1, Q8BJH2
    Related
    ENSMUSP00000052245.8, ENSMUST00000050096.15
    Conserved Domains (1) summary
    cl00214
    Location:137385
    Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
  3. NM_001164101.3NP_001157573.1  gamma-adducin isoform b

    See identical proteins and their annotated locations for NP_001157573.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a. Both variants 3 and 4 encode the same isoform (b).
    Source sequence(s)
    AC138174
    Consensus CDS
    CCDS50467.1
    UniProtKB/TrEMBL
    Q3UNK1, Q8BJH2
    Related
    ENSMUSP00000107370.4, ENSMUST00000111741.10
    Conserved Domains (1) summary
    cl00214
    Location:137385
    Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
  4. NM_001277100.2NP_001264029.1  gamma-adducin isoform a

    See identical proteins and their annotated locations for NP_001264029.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 5 encode the same isoform (a).
    Source sequence(s)
    AC138174
    Consensus CDS
    CCDS29900.1
    UniProtKB/Swiss-Prot
    Q8JZT6, Q9D2M5, Q9QYB5, Q9QYB6
    UniProtKB/TrEMBL
    Q05C56
    Related
    ENSMUSP00000157955.2, ENSMUST00000237430.2
    Conserved Domains (1) summary
    cl00214
    Location:137385
    Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
  5. NM_001413986.1NP_001400915.1  gamma-adducin isoform a

    Status: VALIDATED

    Source sequence(s)
    AC138174
    UniProtKB/Swiss-Prot
    Q8JZT6, Q9D2M5, Q9QYB5, Q9QYB6
  6. NM_001413987.1NP_001400916.1  gamma-adducin isoform b

    Status: VALIDATED

    Source sequence(s)
    AC138174
    UniProtKB/TrEMBL
    Q3UNK1
    Related
    ENSMUSP00000158154.2, ENSMUST00000238130.2
  7. NM_013758.5NP_038786.2  gamma-adducin isoform a

    See identical proteins and their annotated locations for NP_038786.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 5 encode the same isoform (a).
    Source sequence(s)
    AC138174, AK028481
    Consensus CDS
    CCDS29900.1
    UniProtKB/Swiss-Prot
    Q8JZT6, Q9D2M5, Q9QYB5, Q9QYB6
    UniProtKB/TrEMBL
    Q05C56
    Related
    ENSMUSP00000025999.7, ENSMUST00000025999.7
    Conserved Domains (1) summary
    cl00214
    Location:137385
    Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    53128874..53235518
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250961.2XP_030106821.1  gamma-adducin isoform X1

    UniProtKB/Swiss-Prot
    Q8JZT6, Q9D2M5, Q9QYB5, Q9QYB6
    UniProtKB/TrEMBL
    Q05C56
    Conserved Domains (1) summary
    cl00214
    Location:137385
    Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
  2. XM_030250965.2XP_030106825.1  gamma-adducin isoform X1

    UniProtKB/Swiss-Prot
    Q8JZT6, Q9D2M5, Q9QYB5, Q9QYB6
    UniProtKB/TrEMBL
    Q05C56
    Conserved Domains (1) summary
    cl00214
    Location:137385
    Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
  3. XM_030250963.2XP_030106823.1  gamma-adducin isoform X1

    UniProtKB/Swiss-Prot
    Q8JZT6, Q9D2M5, Q9QYB5, Q9QYB6
    UniProtKB/TrEMBL
    Q05C56
    Conserved Domains (1) summary
    cl00214
    Location:137385
    Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
  4. XM_030250960.2XP_030106820.1  gamma-adducin isoform X1

    UniProtKB/Swiss-Prot
    Q8JZT6, Q9D2M5, Q9QYB5, Q9QYB6
    UniProtKB/TrEMBL
    Q05C56
    Conserved Domains (1) summary
    cl00214
    Location:137385
    Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
  5. XM_030250959.2XP_030106819.1  gamma-adducin isoform X1

    UniProtKB/Swiss-Prot
    Q8JZT6, Q9D2M5, Q9QYB5, Q9QYB6
    UniProtKB/TrEMBL
    Q05C56
    Conserved Domains (1) summary
    cl00214
    Location:137385
    Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...