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MCAT malonyl-CoA-acyl carrier protein transacylase [ Homo sapiens (human) ]

Gene ID: 27349, updated on 3-Jan-2019

Summary

Official Symbol
MCATprovided by HGNC
Official Full Name
malonyl-CoA-acyl carrier protein transacylaseprovided by HGNC
Primary source
HGNC:HGNC:29622
See related
Ensembl:ENSG00000100294 MIM:614479
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MT; MCT; MCT1; fabD; NET62; FASN2C
Summary
The protein encoded by this gene is found exclusively in the mitochondrion, where it catalyzes the transfer of a malonyl group from malonyl-CoA to the mitochondrial acyl carrier protein. The encoded protein may be part of a fatty acid synthase complex that is more like the type II prokaryotic and plastid complexes rather than the type I human cytosolic complex. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2012]
Expression
Ubiquitous expression in kidney (RPKM 9.6), testis (RPKM 4.7) and 25 other tissues See more
Orthologs

Genomic context

See MCAT in Genome Data Viewer
Location:
22q13.2
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 22 NC_000022.11 (43132206..43143397, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (43528212..43539403, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein S25 pseudogene 10 Neighboring gene BCL2 interacting killer Neighboring gene translocator protein Neighboring gene tubulin tyrosine ligase like 12

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC47838

Gene Ontology Provided by GOA

Process Evidence Code Pubs
fatty acid beta-oxidation TAS
Traceable Author Statement
more info
 
fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fatty acid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
mitochondrial matrix TAS
Traceable Author Statement
more info
 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
malonyl-CoA-acyl carrier protein transacylase, mitochondrial
Names
[Acyl-carrier-protein] malonyltransferase
[acyl-carrier-protein] S-malonyltransferase
malonyl CoA:ACP acyltransferase (mitochondrial)
mitochondrial malonyl CoA:ACP acyltransferase
mitochondrial malonyltransferase
NP_055322.1
NP_775738.3
XP_011528458.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014507.3NP_055322.1  malonyl-CoA-acyl carrier protein transacylase, mitochondrial isoform b precursor

    See identical proteins and their annotated locations for NP_055322.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (b) is shorter and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AI811069, AL359403, BI464466, BX111669, DB306307
    Consensus CDS
    CCDS14045.1
    UniProtKB/Swiss-Prot
    Q8IVS2
    Related
    ENSP00000331306.5, ENST00000327555.5
    Conserved Domains (1) summary
    cl08282
    Location:12171
    Acyl_transf_1; Acyl transferase domain
  2. NM_173467.4NP_775738.3  malonyl-CoA-acyl carrier protein transacylase, mitochondrial isoform a precursor

    See identical proteins and their annotated locations for NP_775738.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AI811069, AL359401, BI464466, BX111669, DB306307
    Consensus CDS
    CCDS33660.1
    UniProtKB/Swiss-Prot
    Q8IVS2
    Related
    ENSP00000290429.5, ENST00000290429.10
    Conserved Domains (1) summary
    cl08282
    Location:12359
    Acyl_transf_1; Acyl transferase domain

RNA

  1. NR_046423.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' coding region, compared to variant 1, which results in a frameshift and an early stop codon. The transcript is sufficiently abundant to represent as a RefSeq record; however, the predicted protein is not represented because the product is significantly truncated and the transcript is a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA402283, AI811069, AL359401, BI464466, BX111669, DB306307

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p12 Primary Assembly

    Range
    43132206..43143397 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011530156.3XP_011528458.1  malonyl-CoA-acyl carrier protein transacylase, mitochondrial isoform X1

    Conserved Domains (1) summary
    cl08282
    Location:1194
    Acyl_transf_1; Acyl transferase domain
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