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RBMS3 RNA binding motif single stranded interacting protein 3 [ Homo sapiens (human) ]

Gene ID: 27303, updated on 12-Aug-2022

Summary

Official Symbol
RBMS3provided by HGNC
Official Full Name
RNA binding motif single stranded interacting protein 3provided by HGNC
Primary source
HGNC:HGNC:13427
See related
Ensembl:ENSG00000144642 MIM:605786; AllianceGenome:HGNC:13427
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes an RNA-binding protein that belongs to the c-myc gene single-strand binding protein family. These proteins are characterized by the presence of two sets of ribonucleoprotein consensus sequence (RNP-CS) that contain conserved motifs, RNP1 and RNP2, originally described in RNA binding proteins, and required for DNA binding. These proteins have been implicated in such diverse functions as DNA replication, gene transcription, cell cycle progression and apoptosis. The encoded protein was isolated by virtue of its binding to an upstream element of the alpha2(I) collagen promoter. The observation that this protein localizes mostly in the cytoplasm suggests that it may be involved in a cytoplasmic function such as controlling RNA metabolism, rather than transcription. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]
Expression
Broad expression in thyroid (RPKM 7.8), fat (RPKM 6.1) and 23 other tissues See more
Orthologs
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Genomic context

See RBMS3 in Genome Data Viewer
Location:
3p24.1
Exon count:
19
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (29281071..30010395)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (29283417..30012800)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (29322562..30051886)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene mesoderm specific transcript pseudogene 4 Neighboring gene RBMS3 antisense RNA 3 Neighboring gene ribosomal protein S12 pseudogene 5 Neighboring gene RBMS3 antisense RNA 2 Neighboring gene MT-ND4L pseudogene 9 Neighboring gene uncharacterized LOC124906222 Neighboring gene RBMS3 antisense RNA 1 Neighboring gene uncharacterized LOC124906224 Neighboring gene uncharacterized LOC124909358 Neighboring gene small nucleolar RNA U3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A genome wide association study (GWAS) providing evidence of an association between common genetic variants and late radiotherapy toxicity.
EBI GWAS Catalog
Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study.
EBI GWAS Catalog
Genetic variants associated with breast size also influence breast cancer risk.
EBI GWAS Catalog
Genome-wide association scan of dental caries in the permanent dentition.
EBI GWAS Catalog
Genome-wide association with bone mass and geometry in the Framingham Heart Study.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ36544

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables mRNA 3'-UTR AU-rich region binding IDA
Inferred from Direct Assay
more info
PubMed 
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables poly(A) binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables poly(A) binding IDA
Inferred from Direct Assay
more info
PubMed 
enables poly(U) RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables poly(U) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
RNA-binding motif, single-stranded-interacting protein 3
Names
RNA binding motif, single stranded interacting protein
RNA-binding protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003792.3NP_001003792.1  RNA-binding motif, single-stranded-interacting protein 3 isoform 3

    See identical proteins and their annotated locations for NP_001003792.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), also known as DD23-S, lacks a 3 nt segment and an in-frame exon in the coding region, as compared to variant 1. The encoded isoform 3 thus lacks an internal aa and an internal segment, as compared to isoform 1.
    Source sequence(s)
    AC012262, AC021068, AC092795, AC097633, AC098650, AC099048, AK097311, AY236872, CA448021
    Consensus CDS
    CCDS33725.1
    UniProtKB/Swiss-Prot
    Q6XE24
    Related
    ENSP00000373276.2, ENST00000383766.6
    Conserved Domains (3) summary
    TIGR01628
    Location:60392
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12475
    Location:138225
    RRM2_RBMS3; RNA recognition motif 2 found in vertebrate RNA-binding motif, single-stranded-interacting protein 3 (RBMS3)
    cl17169
    Location:56135
    RRM_SF; RNA recognition motif (RRM) superfamily
  2. NM_001003793.3NP_001003793.1  RNA-binding motif, single-stranded-interacting protein 3 isoform 1

    See identical proteins and their annotated locations for NP_001003793.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), also known as DD23-L, encodes the longest isoform (1).
    Source sequence(s)
    AC012262, AC097633, AK097311, AY236871, CA448021
    Consensus CDS
    CCDS33724.1
    UniProtKB/Swiss-Prot
    Q6XE23, Q6XE24
    Related
    ENSP00000373277.2, ENST00000383767.7
    Conserved Domains (2) summary
    cd12475
    Location:139226
    RRM2_RBMS3; RNA recognition motif 2 (RRM2) found in vertebrate RNA-binding motif, single-stranded-interacting protein 3 (RBMS3)
    cd12472
    Location:57136
    RRM1_RBMS3; RNA recognition motif 1 (RRM1) found in vertebrate RNA-binding motif, single-stranded-interacting protein 3 (RBMS3)
  3. NM_001177711.2NP_001171182.1  RNA-binding motif, single-stranded-interacting protein 3 isoform 5

    See identical proteins and their annotated locations for NP_001171182.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (5) is shorter than isoform 1.
    Source sequence(s)
    AC012262, AC097633, AC099048, AK097311, AK292789, CA448021
    Consensus CDS
    CCDS54558.1
    UniProtKB/Swiss-Prot
    Q6XE24
    Related
    ENSP00000397926.1, ENST00000452462.5
    Conserved Domains (3) summary
    TIGR01628
    Location:61394
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12475
    Location:139226
    RRM2_RBMS3; RNA recognition motif 2 (RRM2) found in vertebrate RNA-binding motif, single-stranded-interacting protein 3 (RBMS3)
    cd12472
    Location:57136
    RRM1_RBMS3; RNA recognition motif 1 (RRM1) found in vertebrate RNA-binding motif, single-stranded-interacting protein 3 (RBMS3)
  4. NM_001177712.2NP_001171183.1  RNA-binding motif, single-stranded-interacting protein 3 isoform 4

    See identical proteins and their annotated locations for NP_001171183.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 3' UTR and has multiple differences in the coding region, compared to variant 1. The encoded isoform (4) is shorter and lacks the last aa, compared to isoform 1.
    Source sequence(s)
    AC012262, AW779062, BC117315
    Consensus CDS
    CCDS54557.1
    UniProtKB/Swiss-Prot
    Q6XE24
    Related
    ENSP00000400519.1, ENST00000456853.1
    Conserved Domains (2) summary
    cd12475
    Location:139226
    RRM2_RBMS3; RNA recognition motif 2 (RRM2) found in vertebrate RNA-binding motif, single-stranded-interacting protein 3 (RBMS3)
    cd12472
    Location:57136
    RRM1_RBMS3; RNA recognition motif 1 (RRM1) found in vertebrate RNA-binding motif, single-stranded-interacting protein 3 (RBMS3)
  5. NM_001330696.1NP_001317625.1  RNA-binding motif, single-stranded-interacting protein 3 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) contains an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 6, which is shorter by an amino acid, compared to isoform 1.
    Source sequence(s)
    AC012262, AC021068, AC092795, AC092796, AC097633, AC098650, AC099048, CA448021
    Consensus CDS
    CCDS87056.1
    UniProtKB/TrEMBL
    C9JIJ9
    Related
    ENSP00000395592.1, ENST00000434693.6
    Conserved Domains (2) summary
    cd12475
    Location:138225
    RRM2_RBMS3; RNA recognition motif 2 found in vertebrate RNA-binding motif, single-stranded-interacting protein 3 (RBMS3)
    cl17169
    Location:56135
    RRM_SF; RNA recognition motif (RRM) superfamily
  6. NM_014483.4NP_055298.2  RNA-binding motif, single-stranded-interacting protein 3 isoform 2

    See identical proteins and their annotated locations for NP_055298.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an internal in-frame exon and the last 3' exon, but has an alternate 3' segment, as compared to variant 1. The encoded isoform 2 lacks an internal segment and the last aa, as compared to isoform 1.
    Source sequence(s)
    AC012262, AF023259, AW779062
    Consensus CDS
    CCDS33726.1
    UniProtKB/Swiss-Prot
    Q6XE24
    Related
    ENSP00000273139.9, ENST00000273139.13
    Conserved Domains (3) summary
    TIGR01628
    Location:61394
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12475
    Location:139226
    RRM2_RBMS3; RNA recognition motif 2 (RRM2) found in vertebrate RNA-binding motif, single-stranded-interacting protein 3 (RBMS3)
    cd12472
    Location:57136
    RRM1_RBMS3; RNA recognition motif 1 (RRM1) found in vertebrate RNA-binding motif, single-stranded-interacting protein 3 (RBMS3)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    29281071..30010395
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005265061.3XP_005265118.1  RNA-binding motif, single-stranded-interacting protein 3 isoform X3

    See identical proteins and their annotated locations for XP_005265118.1

    Conserved Domains (3) summary
    cd12475
    Location:139226
    RRM2_RBMS3; RNA recognition motif 2 found in vertebrate RNA-binding motif, single-stranded-interacting protein 3 (RBMS3)
    cl17169
    Location:57136
    RRM_SF; RNA recognition motif (RRM) superfamily
    cl25887
    Location:61393
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
  2. XM_017006180.2XP_016861669.1  RNA-binding motif, single-stranded-interacting protein 3 isoform X5

    Conserved Domains (3) summary
    TIGR01645
    Location:83374
    half-pint; poly-U binding splicing factor, half-pint family
    cd12475
    Location:139226
    RRM2_RBMS3; RNA recognition motif 2 (RRM2) found in vertebrate RNA-binding motif, single-stranded-interacting protein 3 (RBMS3)
    cd12472
    Location:57136
    RRM1_RBMS3; RNA recognition motif 1 (RRM1) found in vertebrate RNA-binding motif, single-stranded-interacting protein 3 (RBMS3)
  3. XM_017006179.2XP_016861668.1  RNA-binding motif, single-stranded-interacting protein 3 isoform X2

    Conserved Domains (3) summary
    TIGR01628
    Location:60393
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12475
    Location:138225
    RRM2_RBMS3; RNA recognition motif 2 (RRM2) found in vertebrate RNA-binding motif, single-stranded-interacting protein 3 (RBMS3)
    cd12472
    Location:56135
    RRM1_RBMS3; RNA recognition motif 1 (RRM1) found in vertebrate RNA-binding motif, single-stranded-interacting protein 3 (RBMS3)
  4. XM_017006181.2XP_016861670.1  RNA-binding motif, single-stranded-interacting protein 3 isoform X6

  5. XM_024453454.2XP_024309222.1  RNA-binding motif, single-stranded-interacting protein 3 isoform X1

    Conserved Domains (2) summary
    cd12475
    Location:139226
    RRM2_RBMS3; RNA recognition motif 2 (RRM2) found in vertebrate RNA-binding motif, single-stranded-interacting protein 3 (RBMS3)
    cd12472
    Location:57136
    RRM1_RBMS3; RNA recognition motif 1 (RRM1) found in vertebrate RNA-binding motif, single-stranded-interacting protein 3 (RBMS3)
  6. XM_005265062.2XP_005265119.1  RNA-binding motif, single-stranded-interacting protein 3 isoform X4

    See identical proteins and their annotated locations for XP_005265119.1

    Conserved Domains (3) summary
    cd12475
    Location:139226
    RRM2_RBMS3; RNA recognition motif 2 found in vertebrate RNA-binding motif, single-stranded-interacting protein 3 (RBMS3)
    cl17169
    Location:57136
    RRM_SF; RNA recognition motif (RRM) superfamily
    cl25887
    Location:61393
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
  7. XM_047447976.1XP_047303932.1  RNA-binding motif, single-stranded-interacting protein 3 isoform X7

  8. XM_005265063.3XP_005265120.1  RNA-binding motif, single-stranded-interacting protein 3 isoform X7

    See identical proteins and their annotated locations for XP_005265120.1

    Conserved Domains (1) summary
    cd12475
    Location:44131
    RRM2_RBMS3; RNA recognition motif 2 found in vertebrate RNA-binding motif, single-stranded-interacting protein 3 (RBMS3)
  9. XM_005265065.6XP_005265122.1  RNA-binding motif, single-stranded-interacting protein 3 isoform X8

    Conserved Domains (1) summary
    cd12475
    Location:30117
    RRM2_RBMS3; RNA recognition motif 2 found in vertebrate RNA-binding motif, single-stranded-interacting protein 3 (RBMS3)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    29283417..30012800
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)