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SPINK4 serine peptidase inhibitor Kazal type 4 [ Homo sapiens (human) ]

Gene ID: 27290, updated on 17-Jun-2024

Summary

Official Symbol
SPINK4provided by HGNC
Official Full Name
serine peptidase inhibitor Kazal type 4provided by HGNC
Primary source
HGNC:HGNC:16646
See related
Ensembl:ENSG00000122711 MIM:613929; AllianceGenome:HGNC:16646
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PEC60; HEL136; PEC-60
Summary
Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity and response to xenobiotic stimulus. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in colon (RPKM 295.5), small intestine (RPKM 212.3) and 2 other tissues See more
Orthologs
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Genomic context

See SPINK4 in Genome Data Viewer
Location:
9p13.3
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (33240167..33248567)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (33258882..33267284)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (33240165..33248565)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene beta-1,4-galactosyltransferase 1 Neighboring gene uncharacterized LOC124902141 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28274 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28275 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28276 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28277 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28278 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28279 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28280 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:33161108-33162102 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:33163497-33163996 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28282 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28283 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:33167185-33167750 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:33167751-33168315 Neighboring gene B4GALT1 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:33172776-33173276 Neighboring gene RNA, U4atac small nuclear 15, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28286 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28287 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr9:33233401-33234600 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28288 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28289 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28290 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19833 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28291 Neighboring gene BAG cochaperone 1 Neighboring gene charged multivesicular body protein 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
serine protease inhibitor Kazal-type 4
Names
epididymis luminal protein 136
gastrointestinal peptide
peptide PEC-60 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014471.3NP_055286.1  serine protease inhibitor Kazal-type 4 precursor

    See identical proteins and their annotated locations for NP_055286.1

    Status: VALIDATED

    Source sequence(s)
    AA296922, AF048700
    Consensus CDS
    CCDS6536.1
    UniProtKB/Swiss-Prot
    O60575, Q2YDT7
    UniProtKB/TrEMBL
    V9HWG8
    Related
    ENSP00000369045.3, ENST00000379721.4
    Conserved Domains (1) summary
    cl00097
    Location:4286
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    33240167..33248567
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    33258882..33267284
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)