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SULT1B1 sulfotransferase family 1B member 1 [ Homo sapiens (human) ]

Gene ID: 27284, updated on 5-Aug-2018

Summary

Official Symbol
SULT1B1provided by HGNC
Official Full Name
sulfotransferase family 1B member 1provided by HGNC
Primary source
HGNC:HGNC:17845
See related
Ensembl:ENSG00000173597 MIM:608436; Vega:OTTHUMG00000129407
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ST1B1; ST1B2; SULT1B2
Summary
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. However, the total genomic length of this gene is greater than that of other SULT1 genes. [provided by RefSeq, Jul 2008]
Expression
Biased expression in duodenum (RPKM 43.3), small intestine (RPKM 41.2) and 5 other tissues See more
Orthologs

Genomic context

See SULT1B1 in Genome Data Viewer
Location:
4q13.3
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 4 NC_000004.12 (69726848..69760712, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (70591838..70626430, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene UDP glucuronosyltransferase family 2 member B7 pseudogene Neighboring gene UDP glucuronosyltransferase family 2 member A2 Neighboring gene UDP glucuronosyltransferase family 2 member A1 complex locus Neighboring gene sulfotransferase family 1D member 1, pseudogene Neighboring gene sulfotransferase family 1E member 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Biological oxidations, organism-specific biosystem (from REACTOME)
    Biological oxidations, organism-specific biosystemAll organisms are constantly exposed to foreign chemicals every day. These can be man-made (drugs, industrial chemicals) or natural (alkaloids, toxins from plants and animals). Uptake is usually via ...
  • Cytosolic sulfonation of small molecules, organism-specific biosystem (from REACTOME)
    Cytosolic sulfonation of small molecules, organism-specific biosystemTwo groups of sulfotransferease (SULT) enzymes catalyze the transfer of a sulfate group from 3-phosphoadenosine 5-phosphosulfate (PAPS) to a hydroxyl group on an acceptor molecule, yielding a sulfona...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metapathway biotransformation, organism-specific biosystem (from WikiPathways)
    Metapathway biotransformation, organism-specific biosystem
    Metapathway biotransformation
  • Phase II conjugation, organism-specific biosystem (from REACTOME)
    Phase II conjugation, organism-specific biosystemPhase II of biotransformation is concerned with conjugation, that is using groups from cofactors to react with functional groups present or introduced from phase I on the compound. The enzymes involv...
  • Sulfation Biotransformation Reaction, organism-specific biosystem (from WikiPathways)
    Sulfation Biotransformation Reaction, organism-specific biosystemMetabolism of xenobiotic compounds consists of phase I and a phase II biotransformation reactions, being compound modification and conjugation reactions respectively. In phase I biotransformation, th...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC13356

Gene Ontology Provided by GOA

Function Evidence Code Pubs
aryl sulfotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
aryl sulfotransferase activity TAS
Traceable Author Statement
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sulfotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
3'-phosphoadenosine 5'-phosphosulfate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
3'-phosphoadenosine 5'-phosphosulfate metabolic process TAS
Traceable Author Statement
more info
 
cellular biogenic amine metabolic process TAS
Traceable Author Statement
more info
PubMed 
epithelial cell differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
ethanol catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
flavonoid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
phenol-containing compound metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
steroid metabolic process IEA
Inferred from Electronic Annotation
more info
 
sulfation IDA
Inferred from Direct Assay
more info
PubMed 
thyroid hormone metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
xenobiotic metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytosol NAS
Non-traceable Author Statement
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
sulfotransferase family cytosolic 1B member 1
Names
sulfotransferase 1B1
sulfotransferase 1B2
sulfotransferase family, cytosolic, 1B, member 1
thyroid hormone sulfotransferase
NP_055280.2
XP_005265733.1
XP_005265734.1
XP_005265735.1
XP_011530175.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014465.3NP_055280.2  sulfotransferase family cytosolic 1B member 1

    See identical proteins and their annotated locations for NP_055280.2

    Status: REVIEWED

    Source sequence(s)
    AC125239, BC010895, BG461453, U95726
    Consensus CDS
    CCDS3530.1
    UniProtKB/Swiss-Prot
    O43704
    Related
    ENSP00000308770.2, OTTHUMP00000159773, ENST00000310613.7, OTTHUMT00000251563
    Conserved Domains (1) summary
    pfam00685
    Location:38288
    Sulfotransfer_1; Sulfotransferase domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p12 Primary Assembly

    Range
    69726848..69760712 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005265676.3XP_005265733.1  sulfotransferase family cytosolic 1B member 1 isoform X1

    Conserved Domains (1) summary
    pfam00685
    Location:43293
    Sulfotransfer_1; Sulfotransferase domain
  2. XM_011531873.2XP_011530175.1  sulfotransferase family cytosolic 1B member 1 isoform X4

    Conserved Domains (1) summary
    pfam00685
    Location:1229
    Sulfotransfer_1; Sulfotransferase domain
  3. XM_005265677.3XP_005265734.1  sulfotransferase family cytosolic 1B member 1 isoform X2

    See identical proteins and their annotated locations for XP_005265734.1

    UniProtKB/Swiss-Prot
    O43704
    Conserved Domains (1) summary
    pfam00685
    Location:38288
    Sulfotransfer_1; Sulfotransferase domain
  4. XM_005265678.3XP_005265735.1  sulfotransferase family cytosolic 1B member 1 isoform X3

    Conserved Domains (1) summary
    pfam00685
    Location:19269
    Sulfotransfer_1; Sulfotransferase domain
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