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SULT1B1 sulfotransferase family 1B member 1 [ Homo sapiens (human) ]

Gene ID: 27284, updated on 22-Sep-2022

Summary

Official Symbol
SULT1B1provided by HGNC
Official Full Name
sulfotransferase family 1B member 1provided by HGNC
Primary source
HGNC:HGNC:17845
See related
Ensembl:ENSG00000173597 MIM:608436; AllianceGenome:HGNC:17845
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ST1B1; ST1B2; SULT1B2
Summary
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. However, the total genomic length of this gene is greater than that of other SULT1 genes. [provided by RefSeq, Jul 2008]
Expression
Biased expression in duodenum (RPKM 43.3), small intestine (RPKM 41.2) and 5 other tissues See more
Orthologs
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Genomic context

See SULT1B1 in Genome Data Viewer
Location:
4q13.3
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (69721167..69760620, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (73055983..73095434, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (70586885..70626338, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene UDP glucuronosyltransferase family 2 member B7 pseudogene Neighboring gene UDP glucuronosyltransferase family 2 member A2 Neighboring gene UDP glucuronosyltransferase family 2 member A1 complex locus Neighboring gene sulfotransferase family 1D member 1, pseudogene Neighboring gene Sharpr-MPRA regulatory region 10246 Neighboring gene sulfotransferase family 1E member 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC13356

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables aryl sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables aryl sulfotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables sulfotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol NAS
Non-traceable Author Statement
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
sulfotransferase 1B1
Names
sulfotransferase 1B2
sulfotransferase family, cytosolic, 1B, member 1
thyroid hormone sulfotransferase
NP_055280.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014465.4NP_055280.2  sulfotransferase 1B1

    See identical proteins and their annotated locations for NP_055280.2

    Status: REVIEWED

    Source sequence(s)
    AC125239, BC010895, BG461453, U95726
    Consensus CDS
    CCDS3530.1
    UniProtKB/Swiss-Prot
    O43704, Q9UK34
    Related
    ENSP00000308770.2, ENST00000310613.8
    Conserved Domains (1) summary
    pfam00685
    Location:38288
    Sulfotransfer_1; Sulfotransferase domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    69721167..69760620 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    73055983..73095434 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)