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KLHL20 kelch like family member 20 [ Homo sapiens (human) ]

Gene ID: 27252, updated on 4-Nov-2018

Summary

Official Symbol
KLHL20provided by HGNC
Official Full Name
kelch like family member 20provided by HGNC
Primary source
HGNC:HGNC:25056
See related
Ensembl:ENSG00000076321 MIM:617679; Vega:OTTHUMG00000040548
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KHLHX; KLEIP; KLHLX
Summary
The protein encoded by this gene is a member of the kelch family of proteins, which is characterized by a 44-56 amino acid repeat motif. The kelch motif appears in many different polypeptide contexts and contains multiple potential protein-protein contact sites. Members of this family are present both throughout the cell and extracellularly, with diverse activities. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 10.0), fat (RPKM 7.7) and 25 other tissues See more
Orthologs

Genomic context

See KLHL20 in Genome Data Viewer
Location:
1q25.1
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (173714912..173786826)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (173684063..173755960)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 9 member C2 (putative) Neighboring gene ankyrin repeat domain 45 Neighboring gene testis expressed 50 Neighboring gene uncharacterized LOC105371619 Neighboring gene ribosomal protein S27 pseudogene 7 Neighboring gene RNA, 7SK small nuclear pseudogene 160 Neighboring gene centromere protein L

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin binding IEA
Inferred from Electronic Annotation
more info
 
interferon-gamma binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
interferon-gamma binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
Golgi to endosome transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi to endosome transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytoskeleton organization TAS
Traceable Author Statement
more info
PubMed 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
post-translational protein modification TAS
Traceable Author Statement
more info
 
proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteasome-mediated ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
protein K33-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein K33-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein transport IEA
Inferred from Electronic Annotation
more info
 
protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
response to interferon-alpha TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Cul3-RING ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
PML body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
PML body IDA
Inferred from Direct Assay
more info
PubMed 
actin cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
axon IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
dendrite IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
trans-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
kelch-like protein 20
Names
Kelch motif containing protein
kelch-like ECT2-interacting protein
kelch-like protein X

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046985.1 RefSeqGene

    Range
    5030..76791
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_014458.3NP_055273.2  kelch-like protein 20

    See identical proteins and their annotated locations for NP_055273.2

    Status: REVIEWED

    Source sequence(s)
    AB026190, BC063418, CB143306
    Consensus CDS
    CCDS1310.1
    UniProtKB/Swiss-Prot
    Q9Y2M5
    UniProtKB/TrEMBL
    A0A024R940
    Related
    ENSP00000209884.4, OTTHUMP00000038347, ENST00000209884.4, OTTHUMT00000097582
    Conserved Domains (2) summary
    PHA03098
    Location:63586
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:355399
    Kelch; KELCH repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    173714912..173786826
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024446472.1XP_024302240.1  kelch-like protein 20 isoform X5

    Conserved Domains (2) summary
    sd00038
    Location:166210
    Kelch; KELCH repeat [structural motif]
    cl28614
    Location:15397
    BTB; Broad-Complex, Tramtrack and Bric a brac
  2. XM_011509420.3XP_011507722.1  kelch-like protein 20 isoform X4

    See identical proteins and their annotated locations for XP_011507722.1

    Conserved Domains (2) summary
    PHA03098
    Location:63538
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:355398
    Kelch; KELCH repeat [structural motif]
  3. XM_005245093.4XP_005245150.1  kelch-like protein 20 isoform X3

    See identical proteins and their annotated locations for XP_005245150.1

    UniProtKB/Swiss-Prot
    Q9Y2M5
    UniProtKB/TrEMBL
    A0A024R940
    Conserved Domains (2) summary
    PHA03098
    Location:63586
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:355399
    Kelch; KELCH repeat [structural motif]
  4. XM_017001054.2XP_016856543.1  kelch-like protein 20 isoform X4

    Conserved Domains (2) summary
    PHA03098
    Location:63538
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:355398
    Kelch; KELCH repeat [structural motif]
  5. XM_024446468.1XP_024302236.1  kelch-like protein 20 isoform X5

    Conserved Domains (2) summary
    sd00038
    Location:166210
    Kelch; KELCH repeat [structural motif]
    cl28614
    Location:15397
    BTB; Broad-Complex, Tramtrack and Bric a brac
  6. XM_017001052.1XP_016856541.1  kelch-like protein 20 isoform X1

  7. XM_017001053.1XP_016856542.1  kelch-like protein 20 isoform X2

RNA

  1. XR_921766.3 RNA Sequence

  2. XR_921767.3 RNA Sequence

  3. XR_001737121.2 RNA Sequence

  4. XR_001737120.1 RNA Sequence

  5. XR_001737119.1 RNA Sequence

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