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GPR162 G protein-coupled receptor 162 [ Homo sapiens (human) ]

Gene ID: 27239, updated on 24-Nov-2020

Summary

Official Symbol
GPR162provided by HGNC
Official Full Name
G protein-coupled receptor 162provided by HGNC
Primary source
HGNC:HGNC:16693
See related
Ensembl:ENSG00000250510
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
A-2; GRCA
Summary
This gene was identified upon genomic analysis of a gene-dense region at human chromosome 12p13. It appears to be mainly expressed in the brain; however, its function is not known. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 25.8), lung (RPKM 3.5) and 6 other tissues See more
Orthologs

Genomic context

See GPR162 in Genome Data Viewer
Location:
12p13.31
Exon count:
5
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (6821821..6827421)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (6930963..6936583)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 380, pseudogene Neighboring gene CD4 molecule Neighboring gene prolyl 3-hydroxylase 3 Neighboring gene G protein subunit beta 3 Neighboring gene cell division cycle associated 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: P3H3

Homology

Clone Names

  • FLJ78837

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
probable G-protein coupled receptor 162
Names
gene rich cluster, A
gene-rich cluster gene A protein
NP_055264.1
NP_062832.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014449.2NP_055264.1  probable G-protein coupled receptor 162 isoform 1

    See identical proteins and their annotated locations for NP_055264.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (A-1) differs in the 5' UTR and the 5' coding region, compared to variant A-2. The resulting isoform (1) contains a distinct N-terminus, compared to isoform 2.
    Source sequence(s)
    U47924, U47925
    Consensus CDS
    CCDS44819.1
    UniProtKB/Swiss-Prot
    Q16538
    Related
    ENSP00000399670.2, ENST00000428545.6
    Conserved Domains (2) summary
    cd14964
    Location:1944
    7tm_GPCRs; TM helix 7 [structural motif]
    cl28897
    Location:651
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  2. NM_019858.2NP_062832.1  probable G-protein coupled receptor 162 isoform 2

    See identical proteins and their annotated locations for NP_062832.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (A-2) represents the longer transcript, and encodes the longer isoform (2).
    Source sequence(s)
    U47924, U47928
    Consensus CDS
    CCDS8563.1
    UniProtKB/Swiss-Prot
    Q16538
    UniProtKB/TrEMBL
    A0A0I9QPQ8
    Related
    ENSP00000311528.3, ENST00000311268.8
    Conserved Domains (1) summary
    pfam00001
    Location:34207
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    6821821..6827421
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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