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Spib Spi-B transcription factor (Spi-1/PU.1 related) [ Mus musculus (house mouse) ]

Gene ID: 272382, updated on 5-Mar-2024

Summary

Official Symbol
Spibprovided by MGI
Official Full Name
Spi-B transcription factor (Spi-1/PU.1 related)provided by MGI
Primary source
MGI:MGI:892986
See related
Ensembl:ENSMUSG00000008193 AllianceGenome:MGI:892986
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Spi-B
Summary
Enables DNA-binding transcription factor activity. Involved in immature B cell differentiation. Acts upstream of or within macrophage differentiation and regulation of transcription, DNA-templated. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in brain and liver. Orthologous to human SPIB (Spi-B transcription factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in spleen adult (RPKM 101.9), mammary gland adult (RPKM 21.1) and 2 other tissues See more
Orthologs
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Genomic context

See Spib in Genome Data Viewer
Location:
7 B3; 7 28.83 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44175419..44181511, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (44525995..44532087, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_18800 Neighboring gene ER membrane protein complex subunit 10 Neighboring gene golgi associated RAB2 interactor 5A Neighboring gene myosin binding protein C, fast-type Neighboring gene STARR-positive B cell enhancer ABC_E10437 Neighboring gene polymerase (DNA directed), delta 1, catalytic subunit Neighboring gene microRNA 7053 Neighboring gene STARR-positive B cell enhancer ABC_E1339 Neighboring gene STARR-positive B cell enhancer ABC_E8170 Neighboring gene STARR-positive B cell enhancer ABC_E2234 Neighboring gene nuclear receptor subfamily 1, group H, member 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (3) 

General gene information

Markers

Gene Ontology Provided by MGI

Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of transcription regulator complex IC
Inferred by Curator
more info
PubMed 

General protein information

Preferred Names
transcription factor Spi-B
Names
Ets transcription factor Spi-B
Spi-1/PU.1 related

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019866.1NP_063919.1  transcription factor Spi-B

    See identical proteins and their annotated locations for NP_063919.1

    Status: VALIDATED

    Source sequence(s)
    CAAA01070168
    Consensus CDS
    CCDS21209.1
    UniProtKB/Swiss-Prot
    O35906, O35907, O35909, O55199
    UniProtKB/TrEMBL
    B9EIW0
    Related
    ENSMUSP00000035539.5, ENSMUST00000035323.6
    Conserved Domains (1) summary
    smart00413
    Location:173261
    ETS; erythroblast transformation specific domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    44175419..44181511 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242628.1XP_030098488.1  transcription factor Spi-B isoform X7

    UniProtKB/TrEMBL
    B9EIW0
    Conserved Domains (1) summary
    smart00413
    Location:155243
    ETS; erythroblast transformation specific domain
  2. XM_006540939.3XP_006541002.1  transcription factor Spi-B isoform X9

  3. XM_006540933.3XP_006540996.1  transcription factor Spi-B isoform X2

    UniProtKB/TrEMBL
    A0A0X1KG64
    Related
    ENSMUSP00000096084.4, ENSMUST00000098483.9
    Conserved Domains (1) summary
    smart00413
    Location:191279
    ETS; erythroblast transformation specific domain
  4. XM_006540938.4XP_006541001.1  transcription factor Spi-B isoform X8

  5. XM_006540934.4XP_006540997.1  transcription factor Spi-B isoform X4

    UniProtKB/TrEMBL
    A0A0X1KG64
    Conserved Domains (1) summary
    smart00413
    Location:174262
    ETS; erythroblast transformation specific domain
  6. XM_006540932.5XP_006540995.1  transcription factor Spi-B isoform X1

    UniProtKB/TrEMBL
    A0A0X1KG64
    Conserved Domains (1) summary
    smart00413
    Location:192280
    ETS; erythroblast transformation specific domain
  7. XM_030242627.2XP_030098487.1  transcription factor Spi-B isoform X6

    UniProtKB/TrEMBL
    A0A0U1RPG0
    Conserved Domains (1) summary
    smart00413
    Location:156244
    ETS; erythroblast transformation specific domain
  8. XM_006540935.5XP_006540998.1  transcription factor Spi-B isoform X3

    UniProtKB/TrEMBL
    A0A0U1RPG0
    Related
    ENSMUSP00000145968.2, ENSMUST00000205506.2
    Conserved Domains (1) summary
    smart00413
    Location:174262
    ETS; erythroblast transformation specific domain
  9. XM_006540936.4XP_006540999.1  transcription factor Spi-B isoform X5

    UniProtKB/TrEMBL
    B9EIW0
    Conserved Domains (1) summary
    smart00413
    Location:164252
    ETS; erythroblast transformation specific domain