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Trp53bp1 transformation related protein 53 binding protein 1 [ Mus musculus (house mouse) ]

Gene ID: 27223, updated on 17-Jan-2023

Summary

Official Symbol
Trp53bp1provided by MGI
Official Full Name
transformation related protein 53 binding protein 1provided by MGI
Primary source
MGI:MGI:1351320
See related
Ensembl:ENSMUSG00000043909 AllianceGenome:MGI:1351320
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
53BP1; m53BP1; p53BP1; Tp53bp1
Summary
Enables damaged DNA binding activity; methylated histone binding activity; and telomeric DNA binding activity. Involved in double-strand break repair via nonhomologous end joining; negative regulation of double-strand break repair via homologous recombination; and positive regulation of isotype switching. Acts upstream of or within DNA repair. Located in chromosome and nuclear body. Part of DNA repair complex. Is expressed in ileum; lung; metanephros; nervous system; and sensory organ. Orthologous to human TP53BP1 (tumor protein p53 binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E14 (RPKM 21.5), whole brain E14.5 (RPKM 20.5) and 24 other tissues See more
Orthologs
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Genomic context

See Trp53bp1 in Genome Data Viewer
Location:
2; 2 E5
Exon count:
35
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (121025316..121126830, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (121194835..121296354, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene leucine carboxyl methyltransferase 2 Neighboring gene adenosine deaminase-like Neighboring gene zinc finger SCAN domains 29 Neighboring gene tubulin, gamma complex associated protein 4 Neighboring gene microtubule-associated protein 1 A Neighboring gene diphosphoinositol pentakisphosphate kinase 1 Neighboring gene predicted gene, 33947 Neighboring gene creatine kinase, mitochondrial 1, ubiquitous

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC100303

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables damaged DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables methylated histone binding IDA
Inferred from Direct Assay
more info
PubMed 
enables methylated histone binding ISO
Inferred from Sequence Orthology
more info
 
enables p53 binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables telomeric DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription coregulator activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription factor binding TAS
Traceable Author Statement
more info
PubMed 
enables ubiquitin modification-dependent histone binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in DNA damage checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within DNA repair IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in double-strand break repair via nonhomologous end joining IDA
Inferred from Direct Assay
more info
PubMed 
involved_in double-strand break repair via nonhomologous end joining IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in double-strand break repair via nonhomologous end joining ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of double-strand break repair via homologous recombination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of isotype switching IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of isotype switching ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in protein homooligomerization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of DNA-templated transcription TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
part_of DNA repair complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, telomeric region IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear body IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in replication fork IDA
Inferred from Direct Assay
more info
PubMed 
located_in site of double-strand break IDA
Inferred from Direct Assay
more info
PubMed 
located_in site of double-strand break ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
TP53-binding protein 1
Names
murine p53-binding protein
p53-binding protein 1
tumor suppressor p53-binding protein 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290830.1NP_001277759.1  TP53-binding protein 1 isoform b

    See identical proteins and their annotated locations for NP_001277759.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    AK036324, AK045416, AK132323, BC079906, BY777325, CA316961, CA752558, CF744583
    Consensus CDS
    CCDS71125.1
    UniProtKB/Swiss-Prot
    P70399
    UniProtKB/TrEMBL
    A0A5H1ZRL7, Q3V1P7, Q8BZ87
    Related
    ENSMUSP00000106277.2, ENSMUST00000110647.8
    Conserved Domains (4) summary
    COG5271
    Location:563890
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    cd17745
    Location:16751786
    BRCT_p53bp1_rpt1; first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins
    pfam09038
    Location:14311551
    53-BP1_Tudor; tumor suppressor p53-binding protein-1 Tudor
    pfam18428
    Location:18141917
    BRCT_3; BRCA1 C Terminus (BRCT) domain
  2. NM_013735.4NP_038763.3  TP53-binding protein 1 isoform a

    See identical proteins and their annotated locations for NP_038763.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a). This variant is supported by the 5'-partial mRNA AJ414734.1, with inference of the first exon from other transcript alignments.
    Source sequence(s)
    AK036324, AK045416, AK132323, BC079906, BY777325, CA316961, CA752558, CF744583
    Consensus CDS
    CCDS50684.1
    UniProtKB/Swiss-Prot
    P70399, Q91YC9
    UniProtKB/TrEMBL
    Q3V1P7, Q8BZ87
    Related
    ENSMUSP00000106278.2, ENSMUST00000110648.8
    Conserved Domains (4) summary
    COG5271
    Location:563890
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    cd17745
    Location:17251836
    BRCT_p53bp1_rpt1; first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins
    pfam09038
    Location:14811601
    53-BP1_Tudor; tumor suppressor p53-binding protein-1 Tudor
    pfam18428
    Location:18641967
    BRCT_3; BRCA1 C Terminus (BRCT) domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    121025316..121126830 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030251686.2XP_030107546.1  TP53-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q91YC9
    Conserved Domains (4) summary
    COG5271
    Location:563890
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    cd17745
    Location:17251836
    BRCT_p53bp1_rpt1; first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins
    pfam09038
    Location:14811601
    53-BP1_Tudor; tumor suppressor p53-binding protein-1 Tudor
    pfam18428
    Location:18641967
    BRCT_3; BRCA1 C Terminus (BRCT) domain
  2. XM_036162270.1XP_036018163.1  TP53-binding protein 1 isoform X13

    Conserved Domains (4) summary
    COG5271
    Location:333792
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    cd17745
    Location:14531564
    BRCT_p53bp1_rpt1; first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins
    pfam09038
    Location:12111331
    53-BP1_Tudor; tumor suppressor p53-binding protein-1 Tudor
    pfam18428
    Location:15921695
    BRCT_3; BRCA1 C Terminus (BRCT) domain
  3. XM_017318937.3XP_017174426.1  TP53-binding protein 1 isoform X11

    Conserved Domains (4) summary
    COG5271
    Location:5631022
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    cd17745
    Location:16351746
    BRCT_p53bp1_rpt1; first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins
    pfam09038
    Location:13911511
    53-BP1_Tudor; tumor suppressor p53-binding protein-1 Tudor
    pfam18428
    Location:17741877
    BRCT_3; BRCA1 C Terminus (BRCT) domain
  4. XM_017318936.3XP_017174425.1  TP53-binding protein 1 isoform X7

    Conserved Domains (4) summary
    COG5271
    Location:5631022
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    cd17745
    Location:16831794
    BRCT_p53bp1_rpt1; first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins
    pfam09038
    Location:14411561
    53-BP1_Tudor; tumor suppressor p53-binding protein-1 Tudor
    pfam18428
    Location:18221925
    BRCT_3; BRCA1 C Terminus (BRCT) domain
  5. XM_036162266.1XP_036018159.1  TP53-binding protein 1 isoform X5

    Conserved Domains (4) summary
    COG5271
    Location:563890
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    cd17745
    Location:16921803
    BRCT_p53bp1_rpt1; first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins
    pfam09038
    Location:14501570
    53-BP1_Tudor; tumor suppressor p53-binding protein-1 Tudor
    pfam18428
    Location:18311934
    BRCT_3; BRCA1 C Terminus (BRCT) domain
  6. XM_036162267.1XP_036018160.1  TP53-binding protein 1 isoform X9

    Conserved Domains (4) summary
    COG5271
    Location:563890
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    cd17745
    Location:16731784
    BRCT_p53bp1_rpt1; first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins
    pfam09038
    Location:14311551
    53-BP1_Tudor; tumor suppressor p53-binding protein-1 Tudor
    pfam18428
    Location:18121915
    BRCT_3; BRCA1 C Terminus (BRCT) domain
  7. XM_011239584.4XP_011237886.1  TP53-binding protein 1 isoform X8

    See identical proteins and their annotated locations for XP_011237886.1

    UniProtKB/TrEMBL
    A0A5H1ZRL7
    Conserved Domains (4) summary
    COG5271
    Location:563890
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    cd17745
    Location:16751786
    BRCT_p53bp1_rpt1; first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins
    pfam09038
    Location:14311551
    53-BP1_Tudor; tumor suppressor p53-binding protein-1 Tudor
    pfam18428
    Location:18141917
    BRCT_3; BRCA1 C Terminus (BRCT) domain
  8. XM_006499661.5XP_006499724.1  TP53-binding protein 1 isoform X2

    Conserved Domains (4) summary
    COG5271
    Location:563890
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    cd17745
    Location:17231834
    BRCT_p53bp1_rpt1; first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins
    pfam09038
    Location:14811601
    53-BP1_Tudor; tumor suppressor p53-binding protein-1 Tudor
    pfam18428
    Location:18621965
    BRCT_3; BRCA1 C Terminus (BRCT) domain
  9. XM_011239581.4XP_011237883.1  TP53-binding protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011237883.1

    UniProtKB/Swiss-Prot
    P70399, Q91YC9
    Conserved Domains (4) summary
    COG5271
    Location:563890
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    cd17745
    Location:17251836
    BRCT_p53bp1_rpt1; first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins
    pfam09038
    Location:14811601
    53-BP1_Tudor; tumor suppressor p53-binding protein-1 Tudor
    pfam18428
    Location:18641967
    BRCT_3; BRCA1 C Terminus (BRCT) domain
  10. XM_030251685.2XP_030107545.1  TP53-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q91YC9
    Conserved Domains (4) summary
    COG5271
    Location:563890
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    cd17745
    Location:17251836
    BRCT_p53bp1_rpt1; first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins
    pfam09038
    Location:14811601
    53-BP1_Tudor; tumor suppressor p53-binding protein-1 Tudor
    pfam18428
    Location:18641967
    BRCT_3; BRCA1 C Terminus (BRCT) domain
  11. XM_036162268.1XP_036018161.1  TP53-binding protein 1 isoform X10

    Conserved Domains (4) summary
    COG5271
    Location:491818
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    cd17745
    Location:16531764
    BRCT_p53bp1_rpt1; first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins
    pfam09038
    Location:14091529
    53-BP1_Tudor; tumor suppressor p53-binding protein-1 Tudor
    pfam18428
    Location:17921895
    BRCT_3; BRCA1 C Terminus (BRCT) domain
  12. XM_036162269.1XP_036018162.1  TP53-binding protein 1 isoform X12

    Conserved Domains (4) summary
    COG5271
    Location:333660
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    cd17745
    Location:14951606
    BRCT_p53bp1_rpt1; first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins
    pfam09038
    Location:12511371
    53-BP1_Tudor; tumor suppressor p53-binding protein-1 Tudor
    pfam18428
    Location:16341737
    BRCT_3; BRCA1 C Terminus (BRCT) domain
  13. XM_030251687.2XP_030107547.1  TP53-binding protein 1 isoform X12

    Conserved Domains (4) summary
    COG5271
    Location:333660
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    cd17745
    Location:14951606
    BRCT_p53bp1_rpt1; first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins
    pfam09038
    Location:12511371
    53-BP1_Tudor; tumor suppressor p53-binding protein-1 Tudor
    pfam18428
    Location:16341737
    BRCT_3; BRCA1 C Terminus (BRCT) domain
  14. XM_011239583.4XP_011237885.1  TP53-binding protein 1 isoform X6

    Conserved Domains (4) summary
    COG5271
    Location:5631022
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    cd17745
    Location:16851796
    BRCT_p53bp1_rpt1; first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins
    pfam09038
    Location:14411561
    53-BP1_Tudor; tumor suppressor p53-binding protein-1 Tudor
    pfam18428
    Location:18241927
    BRCT_3; BRCA1 C Terminus (BRCT) domain
  15. XM_011239582.4XP_011237884.1  TP53-binding protein 1 isoform X4

    Conserved Domains (4) summary
    COG5271
    Location:563890
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    cd17745
    Location:16941805
    BRCT_p53bp1_rpt1; first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins
    pfam09038
    Location:14501570
    53-BP1_Tudor; tumor suppressor p53-binding protein-1 Tudor
    pfam18428
    Location:18331936
    BRCT_3; BRCA1 C Terminus (BRCT) domain
  16. XM_030251688.1XP_030107548.1  TP53-binding protein 1 isoform X14

    Conserved Domains (4) summary
    COG5271
    Location:170497
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    cd17745
    Location:13321443
    BRCT_p53bp1_rpt1; first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins
    pfam09038
    Location:10881208
    53-BP1_Tudor; tumor suppressor p53-binding protein-1 Tudor
    pfam18428
    Location:14711574
    BRCT_3; BRCA1 C Terminus (BRCT) domain
  17. XM_006499662.5XP_006499725.1  TP53-binding protein 1 isoform X3

    Conserved Domains (4) summary
    COG5271
    Location:558885
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    cd17745
    Location:17201831
    BRCT_p53bp1_rpt1; first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins
    pfam09038
    Location:14761596
    53-BP1_Tudor; tumor suppressor p53-binding protein-1 Tudor
    pfam18428
    Location:18591962
    BRCT_3; BRCA1 C Terminus (BRCT) domain
  18. XM_006499668.5XP_006499731.1  TP53-binding protein 1 isoform X16

    Conserved Domains (3) summary
    cd17745
    Location:776887
    BRCT_p53bp1_rpt1; first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins
    pfam09038
    Location:532652
    53-BP1_Tudor; tumor suppressor p53-binding protein-1 Tudor
    pfam18428
    Location:9151018
    BRCT_3; BRCA1 C Terminus (BRCT) domain
  19. XM_011239585.4XP_011237887.1  TP53-binding protein 1 isoform X15

    Related
    ENSMUSP00000114457.2, ENSMUST00000131245.2

RNA

  1. XR_004940621.1 RNA Sequence

  2. XR_003953350.2 RNA Sequence