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IL36A interleukin 36 alpha [ Homo sapiens (human) ]

Gene ID: 27179, updated on 13-Mar-2020

Summary

Official Symbol
IL36Aprovided by HGNC
Official Full Name
interleukin 36 alphaprovided by HGNC
Primary source
HGNC:HGNC:15562
See related
Ensembl:ENSG00000136694 MIM:605509
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FIL1; FIL1E; IL1F6; IL-1F6; IL1(EPSILON); FIL1(EPSILON)
Summary
The protein encoded by this gene is a cytokine that can activate NF-kappa-B and MAPK signaling pathways to generate an inflammatory response. The encoded protein functions primarily in skin and demonstrates increased expression in psoriasis. In addition, decreased expression of this gene has been linked to a poor prognosis in both hepatocellular carcinoma and colorectal cancer patients. [provided by RefSeq, Nov 2015]
Expression
Restricted expression toward esophagus (RPKM 90.8) See more
Orthologs

Genomic context

See IL36A in Genome Data Viewer
Location:
2q14.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (113005459..113011071)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (113763038..113766221)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 23 Neighboring gene interleukin 36 gamma Neighboring gene POLR2D pseudogene 1 Neighboring gene interleukin 36 beta Neighboring gene interleukin 36 receptor antagonist

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC129552, MGC129553

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
interleukin-1 receptor binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cellular response to lipopolysaccharide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
immune response NAS
Non-traceable Author Statement
more info
PubMed 
inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inflammatory response to antigenic stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of interleukin-6 production IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
interleukin-36 alpha
Names
FIL1 epsilon
IL-1 epsilon
IL-1F6 (FIL-1-epsilon)
interleukin 1 family, member 6 (epsilon)
interleukin-1 epsilon
interleukin-1 family member 6

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014440.3NP_055255.1  interleukin-36 alpha

    See identical proteins and their annotated locations for NP_055255.1

    Status: REVIEWED

    Source sequence(s)
    AC016724, AF201831, AK314149
    Consensus CDS
    CCDS42734.1
    UniProtKB/Swiss-Prot
    Q9UHA7
    Related
    ENSP00000259211.6, ENST00000259211.7
    Conserved Domains (1) summary
    cl00094
    Location:15152
    IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    113005459..113011071
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011510965.1XP_011509267.1  interleukin-36 alpha isoform X1

    See identical proteins and their annotated locations for XP_011509267.1

    UniProtKB/Swiss-Prot
    Q9UHA7
    Conserved Domains (1) summary
    cl00094
    Location:15152
    IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
  2. XM_005263639.2XP_005263696.1  interleukin-36 alpha isoform X1

    See identical proteins and their annotated locations for XP_005263696.1

    UniProtKB/Swiss-Prot
    Q9UHA7
    Conserved Domains (1) summary
    cl00094
    Location:15152
    IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
  3. XM_017003806.1XP_016859295.1  interleukin-36 alpha isoform X1

    UniProtKB/Swiss-Prot
    Q9UHA7
    Conserved Domains (1) summary
    cl00094
    Location:15152
    IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
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