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INPP5J inositol polyphosphate-5-phosphatase J [ Homo sapiens (human) ]

Gene ID: 27124, updated on 5-Aug-2022

Summary

Official Symbol
INPP5Jprovided by HGNC
Official Full Name
inositol polyphosphate-5-phosphatase Jprovided by HGNC
Primary source
HGNC:HGNC:8956
See related
Ensembl:ENSG00000185133 MIM:606481; AllianceGenome:HGNC:8956
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PIPP; INPP5; PIB5PA
Summary
Predicted to enable phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity and phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Predicted to be involved in inositol phosphate dephosphorylation; negative regulation of peptidyl-serine phosphorylation; and phosphatidylinositol dephosphorylation. Predicted to act upstream of or within negative regulation of neuron projection development. Located in cytoplasm and ruffle. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in thyroid (RPKM 63.8), small intestine (RPKM 7.6) and 4 other tissues See more
Orthologs
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Genomic context

See INPP5J in Genome Data Viewer
Location:
22q12.2
Exon count:
14
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (31122923..31134697)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (31586420..31598201)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (31518909..31530683)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372995 Neighboring gene uncharacterized LOC124905100 Neighboring gene ribosomal protein S15a pseudogene 37 Neighboring gene phospholipase A2 group III Neighboring gene small nuclear ribonucleoprotein-associated protein N-like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC129984

Gene Ontology Provided by GOA

Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in dendritic shaft IEA
Inferred from Electronic Annotation
more info
 
located_in extrinsic component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in growth cone IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in ruffle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in ruffle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
phosphatidylinositol 4,5-bisphosphate 5-phosphatase A
NP_001002837.1
NP_001271214.1
NP_001271215.1
NP_001271216.1
NP_001271217.1
NP_001271218.1
XP_047297288.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002837.2NP_001002837.1  phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform c

    See identical proteins and their annotated locations for NP_001002837.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame segment in the 5' coding region, compared to variant 1, resulting in an isoform (c) that is shorter than isoform a.
    Source sequence(s)
    AK126610, AW014134, BC109288, BU584792
    Consensus CDS
    CCDS46687.1
    UniProtKB/Swiss-Prot
    Q15735
    Related
    ENSP00000384534.3, ENST00000404390.7
    Conserved Domains (1) summary
    cd09094
    Location:56362
    INPP5c_INPP5J-like; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of inositol polyphosphate 5-phosphatase J and related proteins
  2. NM_001284285.2NP_001271214.1  phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform a

    See identical proteins and their annotated locations for NP_001271214.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC005005, AK092859, AK293992, AW014134
    Consensus CDS
    CCDS63453.1
    UniProtKB/Swiss-Prot
    Q15735, Q9UDT9
    UniProtKB/TrEMBL
    B4DF95
    Related
    ENSP00000333262.5, ENST00000331075.10
    Conserved Domains (1) summary
    cd09094
    Location:423730
    INPP5c_INPP5J-like; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of inositol polyphosphate 5-phosphatase J and related proteins
  3. NM_001284286.1NP_001271215.1  phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform b

    See identical proteins and their annotated locations for NP_001271215.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AC005005, AK293992, AW014134, BU507439, BU584792
    Consensus CDS
    CCDS63454.1
    UniProtKB/TrEMBL
    B4DF95
    Related
    ENSP00000392924.2, ENST00000412277.6
    Conserved Domains (1) summary
    cd09094
    Location:356663
    INPP5c_INPP5J-like; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of inositol polyphosphate 5-phosphatase J and related proteins
  4. NM_001284287.1NP_001271216.1  phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in its 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (d) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AC005005, AK309548, AW014134, BU584792
    Consensus CDS
    CCDS74847.1
    UniProtKB/TrEMBL
    A0A087WVS7
    Related
    ENSP00000479645.1, ENST00000620191.4
    Conserved Domains (1) summary
    cd09094
    Location:1295
    INPP5c_INPP5J-like; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of inositol polyphosphate 5-phosphatase J and related proteins
  5. NM_001284288.1NP_001271217.1  phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform e

    See identical proteins and their annotated locations for NP_001271217.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in its 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (e) is shorter at the N-terminus, compared to isoform a. Both variants 5 and 6 encode isoform e.
    Source sequence(s)
    AC005005, AK095944, AK126610, AW014134, BU584792
    Consensus CDS
    CCDS63455.1
    UniProtKB/Swiss-Prot
    Q15735
    Related
    ENSP00000383150.2, ENST00000400294.6
    Conserved Domains (1) summary
    cd09094
    Location:56363
    INPP5c_INPP5J-like; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of inositol polyphosphate 5-phosphatase J and related proteins
  6. NM_001284289.1NP_001271218.1  phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform e

    See identical proteins and their annotated locations for NP_001271218.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in its 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (e) is shorter at the N-terminus, compared to isoform a. Both variants 5 and 6 encode isoform e.
    Source sequence(s)
    AC005005, AW014134, BC109288, BU584792
    Consensus CDS
    CCDS63455.1
    UniProtKB/Swiss-Prot
    Q15735
    Related
    ENSP00000384596.1, ENST00000405300.5
    Conserved Domains (1) summary
    cd09094
    Location:56363
    INPP5c_INPP5J-like; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of inositol polyphosphate 5-phosphatase J and related proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    31122923..31134697
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047441332.1XP_047297288.1  phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    31586420..31598201
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_014422.2: Suppressed sequence

    Description
    NM_014422.2: This RefSeq was permanently suppressed because it has an additional exon that results in a nonsense-mediated mRNA decay (NMD) candidate.