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DKK3 dickkopf WNT signaling pathway inhibitor 3 [ Homo sapiens (human) ]

Gene ID: 27122, updated on 14-Jun-2020

Summary

Official Symbol
DKK3provided by HGNC
Official Full Name
dickkopf WNT signaling pathway inhibitor 3provided by HGNC
Primary source
HGNC:HGNC:2893
See related
Ensembl:ENSG00000050165 MIM:605416
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RIG; REIC
Summary
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Expression
Biased expression in heart (RPKM 451.8), brain (RPKM 155.8) and 7 other tissues See more
Orthologs

Genomic context

See DKK3 in Genome Data Viewer
Location:
11p15.3
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (11962979..12009827, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (11984543..12031373, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984311 Neighboring gene ubiquitin specific peptidase 47 Neighboring gene H3 histone pseudogene 33 Neighboring gene long intergenic non-protein coding RNA 2547 Neighboring gene GATA motif-containing MPRA enhancer 176/177 Neighboring gene microtubule associated monooxygenase, calponin and LIM domain containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genetic association with overall survival of taxane-treated lung cancer patients - A genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study.
NHGRI GWA Catalog
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
NHGRI GWA Catalog
Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
co-receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
receptor antagonist activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
dickkopf-related protein 3
Names
RIG-like 5-6
RIG-like 7-1
dickkopf 3 homolog
dickkopf homolog 3
dickkopf-3
dkk-3
hDkk-3
regulated in glioma

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001018057.1NP_001018067.1  dickkopf-related protein 3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001018067.1

    Status: REVIEWED

    Source sequence(s)
    AL535720, BC007660, BQ690088, H18461
    Consensus CDS
    CCDS7808.1
    UniProtKB/Swiss-Prot
    Q9UBP4
    Conserved Domains (2) summary
    pfam06607
    Location:208273
    Prokineticin; Prokineticin
    pfam04706
    Location:147196
    Dickkopf_N; Dickkopf N-terminal cysteine-rich region
  2. NM_001330220.2NP_001317149.1  dickkopf-related protein 3 isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AB057591, AC124276, BF724383, BQ894810
    Consensus CDS
    CCDS81555.1
    UniProtKB/Swiss-Prot
    Q9UBP4
    UniProtKB/TrEMBL
    F6SYF8
  3. NM_013253.4NP_037385.2  dickkopf-related protein 3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_037385.2

    Status: REVIEWED

    Source sequence(s)
    AB057591, BC007660, BQ690088, H18461
    Consensus CDS
    CCDS7808.1
    UniProtKB/Swiss-Prot
    Q9UBP4
    Related
    ENSP00000314910.4, ENST00000326932.8
    Conserved Domains (2) summary
    pfam06607
    Location:208273
    Prokineticin; Prokineticin
    pfam04706
    Location:147196
    Dickkopf_N; Dickkopf N-terminal cysteine-rich region
  4. NM_015881.5NP_056965.3  dickkopf-related protein 3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_056965.3

    Status: REVIEWED

    Source sequence(s)
    BC007660, BQ690088, CB156451, H18461
    Consensus CDS
    CCDS7808.1
    UniProtKB/Swiss-Prot
    Q9UBP4
    Related
    ENSP00000379762.2, ENST00000396505.7
    Conserved Domains (2) summary
    pfam06607
    Location:208273
    Prokineticin; Prokineticin
    pfam04706
    Location:147196
    Dickkopf_N; Dickkopf N-terminal cysteine-rich region

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    11962979..12009827 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006718178.2XP_006718241.1  dickkopf-related protein 3 isoform X2

    See identical proteins and their annotated locations for XP_006718241.1

    UniProtKB/Swiss-Prot
    Q9UBP4
    Conserved Domains (2) summary
    pfam06607
    Location:208273
    Prokineticin; Prokineticin
    pfam04706
    Location:147196
    Dickkopf_N; Dickkopf N-terminal cysteine-rich region
  2. XM_017017555.1XP_016873044.1  dickkopf-related protein 3 isoform X1

    UniProtKB/TrEMBL
    F6SYF8
    Related
    ENSP00000433112.1, ENST00000525493.5
  3. XM_017017554.2XP_016873043.1  dickkopf-related protein 3 isoform X1

    UniProtKB/TrEMBL
    F6SYF8
  4. XM_024448441.1XP_024304209.1  dickkopf-related protein 3 isoform X4

  5. XM_024448440.1XP_024304208.1  dickkopf-related protein 3 isoform X3

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