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ARRDC2 arrestin domain containing 2 [ Homo sapiens (human) ]

Gene ID: 27106, updated on 1-Aug-2020

Summary

Official Symbol
ARRDC2provided by HGNC
Official Full Name
arrestin domain containing 2provided by HGNC
Primary source
HGNC:HGNC:25225
See related
Ensembl:ENSG00000105643
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PP2703; CLONE24945
Expression
Ubiquitous expression in bone marrow (RPKM 25.3), fat (RPKM 16.5) and 24 other tissues See more
Orthologs

Genomic context

See ARRDC2 in Genome Data Viewer
Location:
19p13.11
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (18001124..18014102)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (18111944..18124911)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 124 Neighboring gene potassium calcium-activated channel subfamily N member 1 Neighboring gene RNA, 5S ribosomal pseudogene 468 Neighboring gene CS pseudogene 3 Neighboring gene NAD(P)HX epimerase pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
arrestin domain-containing protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025604.3NP_001020775.1  arrestin domain-containing protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001020775.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5'-terminal exon and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC020904, AI420040, AK127940, BG756314
    Consensus CDS
    CCDS32956.1
    UniProtKB/Swiss-Prot
    Q8TBH0
    Related
    ENSP00000368977.1, ENST00000379656.7
    Conserved Domains (2) summary
    smart01017
    Location:176302
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    pfam00339
    Location:17153
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
  2. NM_001286826.2NP_001273755.1  arrestin domain-containing protein 2 isoform 3

    See identical proteins and their annotated locations for NP_001273755.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.
    Source sequence(s)
    AF193051
    UniProtKB/Swiss-Prot
    Q8TBH0
    Conserved Domains (2) summary
    smart01017
    Location:181307
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    pfam00339
    Location:9158
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
  3. NM_015683.2NP_056498.1  arrestin domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_056498.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AF193051
    Consensus CDS
    CCDS12370.1
    UniProtKB/Swiss-Prot
    Q8TBH0
    UniProtKB/TrEMBL
    A0A024R7K1
    Related
    ENSP00000222250.3, ENST00000222250.5
    Conserved Domains (2) summary
    smart01017
    Location:181307
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    pfam00339
    Location:9158
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    18001124..18014102
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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