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DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides 1 [ Homo sapiens (human) ]

Gene ID: 27071, updated on 12-Oct-2019

Summary

Official Symbol
DAPP1provided by HGNC
Official Full Name
dual adaptor of phosphotyrosine and 3-phosphoinositides 1provided by HGNC
Primary source
HGNC:HGNC:16500
See related
Ensembl:ENSG00000070190 MIM:605768
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BAM32
Expression
Broad expression in lymph node (RPKM 16.8), appendix (RPKM 14.4) and 15 other tissues See more
Orthologs

Genomic context

See DAPP1 in Genome Data Viewer
Location:
4q23
Exon count:
13
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (99816827..99872290)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (100737957..100791347)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene microsomal triglyceride transfer protein Neighboring gene chromosome 4 open reading frame 54 Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 Neighboring gene DnaJ heat shock protein family (Hsp40) member B14

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp667E0716

Gene Ontology Provided by GOA

Function Evidence Code Pubs
phosphatidylinositol-3,4,5-trisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol-3,4-bisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
phospholipid binding NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
protein dephosphorylation NAS
Non-traceable Author Statement
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide
Names
B-cell adapter molecule of 32 kDa
b lymphocyte adapter protein Bam32
hDAPP1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001306151.2NP_001293080.1  dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide isoform 2

    See identical proteins and their annotated locations for NP_001293080.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and uses an alternate exon that causes a frameshift in the 3' coding region compared to variant 1. It encodes isoform 2, which is shorter and has a novel C-terminus compared to isoform 1.
    Source sequence(s)
    AF186022, AP001962, BC012924, CA428013
    Consensus CDS
    CCDS77945.1
    UniProtKB/Swiss-Prot
    Q9UN19
    UniProtKB/TrEMBL
    J3KNB3
    Related
    ENSP00000296414.7, ENST00000296414.11
    Conserved Domains (2) summary
    cd10355
    Location:28119
    SH2_DAPP1_BAM32_like; Src homology 2 domain found in dual adaptor for phosphotyrosine and 3-phosphoinositides ( DAPP1)/B lymphocyte adaptor molecule of 32 kDa (Bam32)-like proteins
    cd10573
    Location:163258
    PH_DAPP1; Dual Adaptor for Phosphotyrosine and 3-Phosphoinositides Pleckstrin homology (PH) domain
  2. NM_014395.3NP_055210.2  dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide isoform 1

    See identical proteins and their annotated locations for NP_055210.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AF163254, BC012924, BM968883, CA428013, DN995752
    Consensus CDS
    CCDS47112.1
    UniProtKB/Swiss-Prot
    Q9UN19
    Related
    ENSP00000423602.1, ENST00000512369.2
    Conserved Domains (2) summary
    cd10355
    Location:28119
    SH2_DAPP1_BAM32_like; Src homology 2 domain found in dual adaptor for phosphotyrosine and 3-phosphoinositides ( DAPP1)/B lymphocyte adaptor molecule of 32 kDa (Bam32)-like proteins
    cd10573
    Location:163258
    PH_DAPP1; Dual Adaptor for Phosphotyrosine and 3-Phosphoinositides Pleckstrin homology (PH) domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    99816827..99872290
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008024.1XP_016863513.1  dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide isoform X2

    Conserved Domains (3) summary
    cd10355
    Location:28119
    SH2_DAPP1_BAM32_like; Src homology 2 domain found in dual adaptor for phosphotyrosine and 3-phosphoinositides ( DAPP1)/B lymphocyte adaptor molecule of 32 kDa (Bam32)-like proteins
    pfam00169
    Location:166231
    PH; PH domain
    cl17171
    Location:163230
    PH-like; Pleckstrin homology-like domain
  2. XM_011531840.2XP_011530142.1  dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide isoform X1

    See identical proteins and their annotated locations for XP_011530142.1

    Conserved Domains (2) summary
    cd10355
    Location:28119
    SH2_DAPP1_BAM32_like; Src homology 2 domain found in dual adaptor for phosphotyrosine and 3-phosphoinositides ( DAPP1)/B lymphocyte adaptor molecule of 32 kDa (Bam32)-like proteins
    cd10573
    Location:163258
    PH_DAPP1; Dual Adaptor for Phosphotyrosine and 3-Phosphoinositides Pleckstrin homology (PH) domain
  3. XM_011531842.1XP_011530144.1  dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide isoform X2

    Conserved Domains (3) summary
    cd10355
    Location:28119
    SH2_DAPP1_BAM32_like; Src homology 2 domain found in dual adaptor for phosphotyrosine and 3-phosphoinositides ( DAPP1)/B lymphocyte adaptor molecule of 32 kDa (Bam32)-like proteins
    pfam00169
    Location:166231
    PH; PH domain
    cl17171
    Location:163230
    PH-like; Pleckstrin homology-like domain
  4. XM_017008023.1XP_016863512.1  dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide isoform X2

    Conserved Domains (3) summary
    cd10355
    Location:28119
    SH2_DAPP1_BAM32_like; Src homology 2 domain found in dual adaptor for phosphotyrosine and 3-phosphoinositides ( DAPP1)/B lymphocyte adaptor molecule of 32 kDa (Bam32)-like proteins
    pfam00169
    Location:166231
    PH; PH domain
    cl17171
    Location:163230
    PH-like; Pleckstrin homology-like domain
  5. XM_011531843.3XP_011530145.1  dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide isoform X3

    Conserved Domains (2) summary
    cd10573
    Location:41136
    PH_DAPP1; Dual Adaptor for Phosphotyrosine and 3-Phosphoinositides Pleckstrin homology (PH) domain
    pfam00169
    Location:44133
    PH; PH domain

RNA

  1. XR_001741200.1 RNA Sequence

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