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Bcap31 B cell receptor associated protein 31 [ Mus musculus (house mouse) ]

Gene ID: 27061, updated on 8-Feb-2024

Summary

Official Symbol
Bcap31provided by MGI
Official Full Name
B cell receptor associated protein 31provided by MGI
Primary source
MGI:MGI:1350933
See related
Ensembl:ENSMUSG00000002015 AllianceGenome:MGI:1350933
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bap31
Summary
Enables MHC class I protein binding activity. Acts upstream of or within several processes, including endoplasmic reticulum to Golgi vesicle-mediated transport; protein localization to endoplasmic reticulum exit site; and spermatogenesis. Located in Golgi membrane and plasma membrane. Is expressed in embryo. Human ortholog(s) of this gene implicated in deafness, dystonia, and cerebral hypomyelination and sensorineural hearing loss. Orthologous to human BCAP31 (B cell receptor associated protein 31). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 68.6), subcutaneous fat pad adult (RPKM 42.3) and 28 other tissues See more
Orthologs
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Genomic context

See Bcap31 in Genome Data Viewer
Location:
X A7.3; X 37.38 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (72729784..72761464, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (73686178..73717815, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene pregnancy upregulated non-ubiquitously expressed CaM kinase Neighboring gene STARR-seq mESC enhancer starr_47348 Neighboring gene predicted gene, 32261 Neighboring gene STARR-seq mESC enhancer starr_47349 Neighboring gene solute carrier family 6 (neurotransmitter transporter, creatine), member 8 Neighboring gene STARR-positive B cell enhancer ABC_E11048 Neighboring gene ATP-binding cassette, sub-family D member 1 Neighboring gene STARR-seq mESC enhancer starr_47353 Neighboring gene predicted gene, 25226 Neighboring gene plexin B3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables MHC class I protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in calcium-mediated signaling using intracellular calcium source ISO
Inferred from Sequence Orthology
more info
 
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within endoplasmic reticulum to Golgi vesicle-mediated transport IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within endoplasmic reticulum to Golgi vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within immune response IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of endoplasmic reticulum calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ERAD pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitochondrial calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of retrograde protein transport, ER to cytosol ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to endoplasmic reticulum exit site IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within protein localization to endoplasmic reticulum exit site IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in protein targeting to mitochondrion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
 
involved_in spermatogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi cisterna membrane ISO
Inferred from Sequence Orthology
more info
 
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in clathrin-coated vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in lipid droplet ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondria-associated endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IPI
Inferred from Physical Interaction
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
B-cell receptor-associated protein 31
Names
BCR-associated protein 31
accessory protein BAP31
p28

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313698.2NP_001300627.1  B-cell receptor-associated protein 31 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).
    Source sequence(s)
    AL805924
    Consensus CDS
    CCDS30209.1
    UniProtKB/Swiss-Prot
    A2ALM8, Q61335, Q9D0E9, Q9D8G7
    UniProtKB/TrEMBL
    Q3U9U5
    Conserved Domains (3) summary
    PRK02224
    Location:134237
    PRK02224; DNA double-strand break repair Rad50 ATPase
    pfam05529
    Location:1136
    Bap31; B-cell receptor-associated protein 31-like
    pfam18035
    Location:192245
    Bap31_Bap29_C; Bap31/Bap29 cytoplasmic coiled-coil domain
  2. NM_001426139.1NP_001413068.1  B-cell receptor-associated protein 31 isoform a

    Status: VALIDATED

    Source sequence(s)
    AL805924
    UniProtKB/Swiss-Prot
    A2ALM8, Q61335, Q9D0E9, Q9D8G7
    UniProtKB/TrEMBL
    Q3U9U5
  3. NM_001426140.1NP_001413069.1  B-cell receptor-associated protein 31 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL805924
  4. NM_012060.6NP_036190.2  B-cell receptor-associated protein 31 isoform a

    See identical proteins and their annotated locations for NP_036190.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript. Variants 1, 2, and 3 all encode the same isoform (a).
    Source sequence(s)
    AL805924
    Consensus CDS
    CCDS30209.1
    UniProtKB/Swiss-Prot
    A2ALM8, Q61335, Q9D0E9, Q9D8G7
    UniProtKB/TrEMBL
    Q3U9U5
    Related
    ENSMUSP00000002091.6, ENSMUST00000002091.6
    Conserved Domains (3) summary
    PRK02224
    Location:134237
    PRK02224; DNA double-strand break repair Rad50 ATPase
    pfam05529
    Location:1136
    Bap31; B-cell receptor-associated protein 31-like
    pfam18035
    Location:192245
    Bap31_Bap29_C; Bap31/Bap29 cytoplasmic coiled-coil domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    72729784..72761464 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006528048.4XP_006528111.1  B-cell receptor-associated protein 31 isoform X1

    See identical proteins and their annotated locations for XP_006528111.1

    UniProtKB/Swiss-Prot
    A2ALM8, Q61335, Q9D0E9, Q9D8G7
    UniProtKB/TrEMBL
    Q3U9U5
    Conserved Domains (3) summary
    PRK02224
    Location:134237
    PRK02224; DNA double-strand break repair Rad50 ATPase
    pfam05529
    Location:1136
    Bap31; B-cell receptor-associated protein 31-like
    pfam18035
    Location:192245
    Bap31_Bap29_C; Bap31/Bap29 cytoplasmic coiled-coil domain