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Gsdmc3 gasdermin C3 [ Mus musculus (house mouse) ]

Gene ID: 270328, updated on 17-Aug-2024

Summary

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Official Symbol
Gsdmc3provided by MGI
Official Full Name
gasdermin C3provided by MGI
Primary source
MGI:MGI:3580656
See related
Ensembl:ENSMUSG00000055827 AllianceGenome:MGI:3580656
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9930109F21Rik
Summary
Predicted to enable phosphatidylinositol-4,5-bisphosphate binding activity; phosphatidylinositol-4-phosphate binding activity; and phosphatidylserine binding activity. Predicted to be involved in defense response to bacterium and pyroptosis. Predicted to act upstream of or within programmed cell death. Predicted to be located in cytoplasm. Is expressed in gut and metanephros. Orthologous to human GSDMC (gasdermin C). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 119.5), colon adult (RPKM 32.7) and 1 other tissue See more
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Genomic context

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Location:
15 D1; 15 27.99 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (63729454..63750428, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (63857605..63878579, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene gasdermin C2 Neighboring gene gasdermin C-like 1 Neighboring gene gasdermin C-like 2 Neighboring gene gasdermin C4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Members of a novel gene family, Gsdm, are expressed exclusively in the epithelium of the skin and gastrointestinal tract in a highly tissue-specific manner. Tamura M, et al. Genomics, 2007 May. PMID 17350798
  2. Cellular heterogeneity in the ureteric progenitor niche and distinct profiles of branching morphogenesis in organ development. Rutledge EA, et al. Development, 2017 Sep 1. PMID 28705898, Free PMC Article
  3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables phosphatidylinositol-4,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-4-phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylserine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables wide pore channel activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in defense response to bacterium IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within programmed cell death IEA
Inferred from Electronic Annotation
more info
  
involved_in pyroptotic inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pyroptotic inflammatory response ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
gasdermin-C3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_183194.3 → NP_899017.2  gasdermin-C3

    See identical proteins and their annotated locations for NP_899017.2

    Status: VALIDATED

    Source sequence(s)
    AK037079, BC099685
    Consensus CDS
    CCDS37088.1
    UniProtKB/Swiss-Prot
    E9QJY6, Q8CB12
    Related
    ENSMUSP00000139472.2, ENSMUST00000190682.7
    Conserved Domains (2) summary
    pfam04598
    Location:4 → 232
    Gasdermin; Gasdermin family
    pfam17708
    Location:270 → 441
    Gasdermin_C; Gasdermin PUB domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    63729454..63750428 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017316650.2 → XP_017172139.1  gasdermin-C3 isoform X1

    UniProtKB/Swiss-Prot
    E9QJY6, Q8CB12
    Related
    ENSMUSP00000087339.6, ENSMUST00000089894.6
    Conserved Domains (2) summary
    pfam04598
    Location:4 → 232
    Gasdermin; Gasdermin family
    pfam17708
    Location:270 → 441
    Gasdermin_C; Gasdermin PUB domain

  2. XM_017316648.2 → XP_017172137.1  gasdermin-C3 isoform X1

    UniProtKB/Swiss-Prot
    E9QJY6, Q8CB12
    Conserved Domains (2) summary
    pfam04598
    Location:4 → 232
    Gasdermin; Gasdermin family
    pfam17708
    Location:270 → 441
    Gasdermin_C; Gasdermin PUB domain

  3. XM_017316652.2 → XP_017172141.1  gasdermin-C3 isoform X1

    UniProtKB/Swiss-Prot
    E9QJY6, Q8CB12
    Conserved Domains (2) summary
    pfam04598
    Location:4 → 232
    Gasdermin; Gasdermin family
    pfam17708
    Location:270 → 441
    Gasdermin_C; Gasdermin PUB domain

  4. XM_017316647.2 → XP_017172136.1  gasdermin-C3 isoform X1

    UniProtKB/Swiss-Prot
    E9QJY6, Q8CB12
    Conserved Domains (2) summary
    pfam04598
    Location:4 → 232
    Gasdermin; Gasdermin family
    pfam17708
    Location:270 → 441
    Gasdermin_C; Gasdermin PUB domain

  5. XM_017316643.2 → XP_017172132.1  gasdermin-C3 isoform X1

    UniProtKB/Swiss-Prot
    E9QJY6, Q8CB12
    Conserved Domains (2) summary
    pfam04598
    Location:4 → 232
    Gasdermin; Gasdermin family
    pfam17708
    Location:270 → 441
    Gasdermin_C; Gasdermin PUB domain

  6. XM_017316642.2 → XP_017172131.1  gasdermin-C3 isoform X1

    UniProtKB/Swiss-Prot
    E9QJY6, Q8CB12
    Conserved Domains (2) summary
    pfam04598
    Location:4 → 232
    Gasdermin; Gasdermin family
    pfam17708
    Location:270 → 441
    Gasdermin_C; Gasdermin PUB domain

  7. XM_017316640.2 → XP_017172129.1  gasdermin-C3 isoform X1

    UniProtKB/Swiss-Prot
    E9QJY6, Q8CB12
    Conserved Domains (2) summary
    pfam04598
    Location:4 → 232
    Gasdermin; Gasdermin family
    pfam17708
    Location:270 → 441
    Gasdermin_C; Gasdermin PUB domain

  8. XM_017316651.2 → XP_017172140.1  gasdermin-C3 isoform X1

    UniProtKB/Swiss-Prot
    E9QJY6, Q8CB12
    Conserved Domains (2) summary
    pfam04598
    Location:4 → 232
    Gasdermin; Gasdermin family
    pfam17708
    Location:270 → 441
    Gasdermin_C; Gasdermin PUB domain

  9. XM_017316645.2 → XP_017172134.1  gasdermin-C3 isoform X1

    UniProtKB/Swiss-Prot
    E9QJY6, Q8CB12
    Conserved Domains (2) summary
    pfam04598
    Location:4 → 232
    Gasdermin; Gasdermin family
    pfam17708
    Location:270 → 441
    Gasdermin_C; Gasdermin PUB domain

  10. XM_017316641.2 → XP_017172130.1  gasdermin-C3 isoform X1

    UniProtKB/Swiss-Prot
    E9QJY6, Q8CB12
    Conserved Domains (2) summary
    pfam04598
    Location:4 → 232
    Gasdermin; Gasdermin family
    pfam17708
    Location:270 → 441
    Gasdermin_C; Gasdermin PUB domain

  11. XM_017316638.2 → XP_017172127.1  gasdermin-C3 isoform X1

    UniProtKB/Swiss-Prot
    E9QJY6, Q8CB12
    Conserved Domains (2) summary
    pfam04598
    Location:4 → 232
    Gasdermin; Gasdermin family
    pfam17708
    Location:270 → 441
    Gasdermin_C; Gasdermin PUB domain

  12. XM_017316649.2 → XP_017172138.1  gasdermin-C3 isoform X1

    UniProtKB/Swiss-Prot
    E9QJY6, Q8CB12
    Conserved Domains (2) summary
    pfam04598
    Location:4 → 232
    Gasdermin; Gasdermin family
    pfam17708
    Location:270 → 441
    Gasdermin_C; Gasdermin PUB domain

  13. XM_017316644.2 → XP_017172133.1  gasdermin-C3 isoform X1

    UniProtKB/Swiss-Prot
    E9QJY6, Q8CB12
    Conserved Domains (2) summary
    pfam04598
    Location:4 → 232
    Gasdermin; Gasdermin family
    pfam17708
    Location:270 → 441
    Gasdermin_C; Gasdermin PUB domain

  14. XM_017316639.2 → XP_017172128.1  gasdermin-C3 isoform X1

    UniProtKB/Swiss-Prot
    E9QJY6, Q8CB12
    Conserved Domains (2) summary
    pfam04598
    Location:4 → 232
    Gasdermin; Gasdermin family
    pfam17708
    Location:270 → 441
    Gasdermin_C; Gasdermin PUB domain

  15. XM_017316646.2 → XP_017172135.1  gasdermin-C3 isoform X1

    UniProtKB/Swiss-Prot
    E9QJY6, Q8CB12
    Conserved Domains (2) summary
    pfam04598
    Location:4 → 232
    Gasdermin; Gasdermin family
    pfam17708
    Location:270 → 441
    Gasdermin_C; Gasdermin PUB domain

  16. XM_006521025.4 → XP_006521088.1  gasdermin-C3 isoform X1

    See identical proteins and their annotated locations for XP_006521088.1

    UniProtKB/Swiss-Prot
    E9QJY6, Q8CB12
    Related
    ENSMUSP00000140272.2, ENSMUST00000185526.7
    Conserved Domains (2) summary
    pfam04598
    Location:4 → 232
    Gasdermin; Gasdermin family
    pfam17708
    Location:270 → 441
    Gasdermin_C; Gasdermin PUB domain

  17. XM_017316653.2 → XP_017172142.1  gasdermin-C3 isoform X1

    UniProtKB/Swiss-Prot
    E9QJY6, Q8CB12
    Conserved Domains (2) summary
    pfam04598
    Location:4 → 232
    Gasdermin; Gasdermin family
    pfam17708
    Location:270 → 441
    Gasdermin_C; Gasdermin PUB domain

  18. XM_011245648.3 → XP_011243950.1  gasdermin-C3 isoform X1

    See identical proteins and their annotated locations for XP_011243950.1

    UniProtKB/Swiss-Prot
    E9QJY6, Q8CB12
    Conserved Domains (2) summary
    pfam04598
    Location:4 → 232
    Gasdermin; Gasdermin family
    pfam17708
    Location:270 → 441
    Gasdermin_C; Gasdermin PUB domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CB12.2 GenPept UniProtKB/Swiss-Prot:Q8CB12

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