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Lhfpl4 lipoma HMGIC fusion partner-like protein 4 [ Mus musculus (house mouse) ]

Gene ID: 269788, updated on 21-Apr-2024

Summary

Official Symbol
Lhfpl4provided by MGI
Official Full Name
lipoma HMGIC fusion partner-like protein 4provided by MGI
Primary source
MGI:MGI:3057108
See related
Ensembl:ENSMUSG00000042873 AllianceGenome:MGI:3057108
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA4027; B230384L07; 1190004M23Rik
Summary
Enables GABA receptor binding activity. Involved in gamma-aminobutyric acid receptor clustering and regulation of inhibitory synapse assembly. Located in inhibitory synapse and postsynaptic membrane. Is expressed in brain; heart; intestine; lung; and reproductive system. Orthologous to human LHFPL4 (LHFPL tetraspan subfamily member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in whole brain E14.5 (RPKM 16.6), CNS E18 (RPKM 16.3) and 6 other tissues See more
Orthologs
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Genomic context

Location:
6 E3; 6 52.74 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (113145048..113172345, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (113168087..113195384, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene gene trap ROSA 26, Philippe Soriano Neighboring gene THUMP domain containing 3 Neighboring gene STARR-seq mESC enhancer starr_17032 Neighboring gene STARR-seq mESC enhancer starr_17033 Neighboring gene SET domain containing 5 Neighboring gene STARR-positive B cell enhancer ABC_E683 Neighboring gene myotubularin related protein 14 Neighboring gene STARR-seq mESC enhancer starr_17036 Neighboring gene copine family member IX

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Clone Names

  • KIAA4027, MGC65621

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GABA receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GABA receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables GABA receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in GABA-ergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in GABA-ergic synapse IEP
Inferred from Expression Pattern
more info
PubMed 
is_active_in GABA-ergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in inhibitory synapse IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in inhibitory synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in inhibitory synapse ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in postsynaptic specialization IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic specialization IEP
Inferred from Expression Pattern
more info
PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
LHFPL tetraspan subfamily member 4 protein
Names
GABAA receptor regulatory Lhfpl4
lipoma HMGIC fusion partner-like 4 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177763.3NP_808431.2  LHFPL tetraspan subfamily member 4 protein

    See identical proteins and their annotated locations for NP_808431.2

    Status: VALIDATED

    Source sequence(s)
    AI847853, AK220449, BB645074, BC085130
    Consensus CDS
    CCDS39591.1
    UniProtKB/Swiss-Prot
    Q5DTS1, Q5U4E0, Q8BQU2
    Related
    ENSMUSP00000124470.2, ENSMUST00000162280.2
    Conserved Domains (1) summary
    pfam10242
    Location:22200
    L_HMGIC_fpl; Lipoma HMGIC fusion partner-like protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    113145048..113172345 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)