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GIP gastric inhibitory polypeptide [ Homo sapiens (human) ]

Gene ID: 2695, updated on 6-Sep-2021

Summary

Official Symbol
GIPprovided by HGNC
Official Full Name
gastric inhibitory polypeptideprovided by HGNC
Primary source
HGNC:HGNC:4270
See related
Ensembl:ENSG00000159224 MIM:137240
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes an incretin hormone and belongs to the glucagon superfamily. The encoded protein is important in maintaining glucose homeostasis as it is a potent stimulator of insulin secretion from pancreatic beta-cells following food ingestion and nutrient absorption. This gene stimulates insulin secretion via its G protein-coupled receptor activation of adenylyl cyclase and other signal transduction pathways. It is a relatively poor inhibitor of gastric acid secretion. [provided by RefSeq, Jul 2008]
Expression
Biased expression in duodenum (RPKM 96.0) and small intestine (RPKM 33.9) See more
Orthologs
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Genomic context

See GIP in Genome Data Viewer
Location:
17q21.32
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (48958554..48968596, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (47035916..47045958, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene SNF8 subunit of ESCRT-II Neighboring gene RNA, U1 small nuclear 42, pseudogene Neighboring gene insulin like growth factor 2 mRNA binding protein 1 Neighboring gene COX assembly mitochondrial protein homolog pseudogene Neighboring gene RNA, U6 small nuclear 826, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables gastric inhibitory polypeptide receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables glucagon receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables hormone activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in adult locomotory behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in digestive system development IEA
Inferred from Electronic Annotation
more info
 
involved_in endocrine pancreas development IEA
Inferred from Electronic Annotation
more info
 
involved_in exploration behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in female pregnancy IEA
Inferred from Electronic Annotation
more info
 
involved_in gastric inhibitory peptide signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in long-term synaptic potentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in memory IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cAMP-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of glucagon secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of glucose transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of insulin secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of insulin secretion TAS
Traceable Author Statement
more info
PubMed 
involved_in response to acidic pH IEA
Inferred from Electronic Annotation
more info
 
involved_in response to amino acid IEA
Inferred from Electronic Annotation
more info
 
involved_in response to axon injury IEA
Inferred from Electronic Annotation
more info
 
involved_in response to glucose IEA
Inferred from Electronic Annotation
more info
 
involved_in response to lipid IEA
Inferred from Electronic Annotation
more info
 
involved_in response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
 
involved_in response to peptide hormone IEA
Inferred from Electronic Annotation
more info
 
involved_in response to selenium ion IEA
Inferred from Electronic Annotation
more info
 
involved_in response to starvation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
involved_in triglyceride homeostasis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
located_in secretory granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
gastric inhibitory polypeptide
Names
glucose-dependent insulinotropic polypeptide
incretin hormone

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004123.3NP_004114.1  gastric inhibitory polypeptide preproprotein

    See identical proteins and their annotated locations for NP_004114.1

    Status: REVIEWED

    Source sequence(s)
    AC091133, BC069100, M18185
    Consensus CDS
    CCDS11542.1
    UniProtKB/Swiss-Prot
    P09681
    Related
    ENSP00000350005.2, ENST00000357424.2
    Conserved Domains (1) summary
    pfam00123
    Location:5278
    Hormone_2; Peptide hormone

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    48958554..48968596 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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