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Ctif CBP80/20-dependent translation initiation factor [ Mus musculus (house mouse) ]

Gene ID: 269037, updated on 26-Sep-2022

Summary

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Official Symbol
Ctifprovided by MGI
Official Full Name
CBP80/20-dependent translation initiation factorprovided by MGI
Primary source
MGI:MGI:2685518
See related
Ensembl:ENSMUSG00000052928 AllianceGenome:MGI:2685518
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm672
Summary
Predicted to enable translation activator activity. Predicted to be involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay and regulation of translational initiation. Predicted to act upstream of or within regulation of translation. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in cytosol. Is expressed in central nervous system; ganglia; and neural retina. Orthologous to human CTIF (cap binding complex dependent translation initiation factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 10.9), CNS E18 (RPKM 10.3) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Ctif in Genome Data Viewer
Location:
18; 18 E3
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (75564276..75830767, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (75431205..75697696, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene 20544 Neighboring gene SMAD family member 7 Neighboring gene predicted gene, 41776 Neighboring gene predicted gene, 52357 Neighboring gene VISTA enhancers mm18 and mm257 Neighboring gene predicted gene 10532 Neighboring gene RIKEN cDNA 1700034B16 gene Neighboring gene thymosin, beta 10 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A new MIF4G domain-containing protein, CTIF, directs nuclear cap-binding protein CBP80/20-dependent translation. Kim KM, et al. Genes Dev, 2009 Sep 1. PMID 19648179, Free PMC Article
  2. A collection of cDNAs enriched in upper cortical layers of the embryonic mouse brain. García-Frigola C, et al. Brain Res Mol Brain Res, 2004 Mar 30. PMID 15010206
  3. The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis. Menon S, et al. Mol Biol Cell, 2021 Feb 15. PMID 33378226, Free PMC Article
  4. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
  5. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article

See all (19) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC67202

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables translation activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Process Evidence Code Pubs
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of translation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in regulation of translational initiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
CBP80/20-dependent translation initiation factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001408302.1 → NP_001395231.1  CBP80/20-dependent translation initiation factor isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC113528, AC120156, AC120176

  2. NM_001408303.1 → NP_001395232.1  CBP80/20-dependent translation initiation factor isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC113528, AC120156, AC120176

  3. NM_001408304.1 → NP_001395233.1  CBP80/20-dependent translation initiation factor isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC113528, AC120156, AC120176

  4. NM_001408305.1 → NP_001395234.1  CBP80/20-dependent translation initiation factor isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC113528, AC120156, AC120176
    UniProtKB/TrEMBL
    E9Q1U6

  5. NM_001408306.1 → NP_001395235.1  CBP80/20-dependent translation initiation factor isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC113528, AC120156, AC120176
    UniProtKB/TrEMBL
    E9Q1U6

  6. NM_001408307.1 → NP_001395236.1  CBP80/20-dependent translation initiation factor isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC113528, AC120156, AC120176

  7. NM_201354.3 → NP_958742.2  CBP80/20-dependent translation initiation factor isoform 2

    See identical proteins and their annotated locations for NP_958742.2

    Status: VALIDATED

    Source sequence(s)
    AC113528, AC120156, AC120176
    Consensus CDS
    CCDS37861.1
    UniProtKB/Swiss-Prot
    Q6PEE2
    UniProtKB/TrEMBL
    E9Q1U6
    Related
    ENSMUSP00000129974.2, ENSMUST00000165559.3
    Conserved Domains (2) summary
    PTZ00449
    Location:259 → 395
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam02854
    Location:402 → 602
    MIF4G; MIF4G domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    75564276..75830767 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006525973.4 → XP_006526036.1  CBP80/20-dependent translation initiation factor isoform X2

    Conserved Domains (1) summary
    pfam02854
    Location:379 → 579
    MIF4G; MIF4G domain

  2. XM_006525967.4 → XP_006526030.1  CBP80/20-dependent translation initiation factor isoform X1

    UniProtKB/TrEMBL
    E9Q1U6
    Conserved Domains (2) summary
    PTZ00449
    Location:259 → 395
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam02854
    Location:402 → 602
    MIF4G; MIF4G domain

  3. XM_030250483.1 → XP_030106343.1  CBP80/20-dependent translation initiation factor isoform X2

    Conserved Domains (1) summary
    pfam02854
    Location:379 → 579
    MIF4G; MIF4G domain

  4. XM_006525968.4 → XP_006526031.1  CBP80/20-dependent translation initiation factor isoform X1

    See identical proteins and their annotated locations for XP_006526031.1

    UniProtKB/TrEMBL
    E9Q1U6
    Conserved Domains (2) summary
    PTZ00449
    Location:259 → 395
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam02854
    Location:402 → 602
    MIF4G; MIF4G domain

  5. XM_036161163.1 → XP_036017056.1  CBP80/20-dependent translation initiation factor isoform X2

    Conserved Domains (1) summary
    pfam02854
    Location:379 → 579
    MIF4G; MIF4G domain

  6. XM_036161162.1 → XP_036017055.1  CBP80/20-dependent translation initiation factor isoform X1

    UniProtKB/TrEMBL
    E9Q1U6
    Conserved Domains (2) summary
    PTZ00449
    Location:259 → 395
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam02854
    Location:402 → 602
    MIF4G; MIF4G domain

  7. XM_030250482.2 → XP_030106342.1  CBP80/20-dependent translation initiation factor isoform X1

    Conserved Domains (2) summary
    PTZ00449
    Location:259 → 395
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam02854
    Location:402 → 602
    MIF4G; MIF4G domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PEE2.2 GenPept UniProtKB/Swiss-Prot:Q6PEE2

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