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Acot1 acyl-CoA thioesterase 1 [ Mus musculus (house mouse) ]

Gene ID: 26897, updated on 9-May-2024

Summary

Official Symbol
Acot1provided by MGI
Official Full Name
acyl-CoA thioesterase 1provided by MGI
Primary source
MGI:MGI:1349396
See related
Ensembl:ENSMUSG00000072949 AllianceGenome:MGI:1349396
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ACH2; Cte1; CTE-1; CTE-I; D12Ucla1
Summary
Enables acyl-CoA hydrolase activity. Acts upstream of or within long-chain fatty acid metabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and sensory organ. Orthologous to human ACOT1 (acyl-CoA thioesterase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E18 (RPKM 44.5), kidney adult (RPKM 41.4) and 26 other tissues See more
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Genomic context

See Acot1 in Genome Data Viewer
Location:
12 D1; 12 39.0 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (84056276..84064444)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (84009502..84017670)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene HEAT repeat containing 4 Neighboring gene ribosomal oxygenase 1 Neighboring gene STARR-seq mESC enhancer starr_32720 Neighboring gene acyl-CoA thioesterase 2 Neighboring gene STARR-seq mESC enhancer starr_32721 Neighboring gene STARR-seq mESC enhancer starr_32722 Neighboring gene predicted gene, 40474 Neighboring gene acyl-CoA thioesterase 4 Neighboring gene acyl-CoA thioesterase 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carboxylic ester hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables fatty acyl-CoA hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables fatty acyl-CoA hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables fatty acyl-CoA hydrolase activity ISO
Inferred from Sequence Orthology
more info
 
enables fatty acyl-CoA hydrolase activity TAS
Traceable Author Statement
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables thiolester hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm TAS
Traceable Author Statement
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
acyl-coenzyme A thioesterase 1
Names
acyl-CoA thioesterase 1, cytosolic
cytosolic acyl-CoA thioesterase 1
inducible cytosolic acyl-coenzyme A thioester hydrolase
long chain acyl-CoA hydrolase
long chain acyl-CoA thioester hydrolase
palmitoyl-coenzyme A thioesterase
NP_036136.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012006.2NP_036136.1  acyl-coenzyme A thioesterase 1

    See identical proteins and their annotated locations for NP_036136.1

    Status: PROVISIONAL

    Source sequence(s)
    AC133183
    Consensus CDS
    CCDS36487.1
    UniProtKB/Swiss-Prot
    O55137, Q549A9
    UniProtKB/TrEMBL
    Q99L15
    Related
    ENSMUSP00000126448.2, ENSMUST00000168120.3
    Conserved Domains (3) summary
    pfam08840
    Location:204410
    BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal
    pfam04775
    Location:16137
    Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region
    cl21494
    Location:145257
    Abhydrolase; alpha/beta hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    84056276..84064444
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)