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Cops4 COP9 signalosome subunit 4 [ Mus musculus (house mouse) ]

Gene ID: 26891, updated on 7-Apr-2025

Summary

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Official Symbol
Cops4provided by MGI
Official Full Name
COP9 signalosome subunit 4provided by MGI
Primary source
MGI:MGI:1349414
See related
Ensembl:ENSMUSG00000035297 AllianceGenome:MGI:1349414
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SGN4; D5Ertd774e
Summary
Predicted to be involved in protein deneddylation. Part of COP9 signalosome. Is expressed in central nervous system; male reproductive system; and urinary system. Orthologous to human COPS4 (COP9 signalosome subunit 4). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Ubiquitous expression in testis adult (RPKM 42.5), placenta adult (RPKM 24.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Cops4 in Genome Data Viewer
Location:
5 E4; 5 48.49 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (100666223..100695668)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (100518295..100547802)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene lin-54 DREAM MuvB core complex component Neighboring gene STARR-seq mESC enhancer starr_13725 Neighboring gene STARR-seq mESC enhancer starr_13727 Neighboring gene STARR-positive B cell enhancer ABC_E2163 Neighboring gene predicted gene, 19620 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:100998499-100998608 Neighboring gene placenta-specific 8 Neighboring gene STARR-positive B cell enhancer ABC_E11295 Neighboring gene STARR-positive B cell enhancer ABC_E11296 Neighboring gene STARR-positive B cell enhancer mm9_chr5:101027025-101027325 Neighboring gene STARR-positive B cell enhancer ABC_E9256 Neighboring gene coenzyme Q2 4-hydroxybenzoate polyprenyltransferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. COP9 Signalosome Subunit 3 Restricts Neuroinflammatory Responses During Cerebral Ischemia/Reperfusion Injury Through Stabilizing Suppressor of Cytokine Signaling 3 Protein. Liang E, et al. Neuropsychiatr Dis Treat, 2021. PMID 33911869, Free PMC Article
  2. Electron microscopy and in vitro deneddylation reveal similar architectures and biochemistry of isolated human and Flag-mouse COP9 signalosome complexes. Rockel B, et al. Biochem Biophys Res Commun, 2014 Jul 25. PMID 24973710
  3. The cytoplasmic shuttling and subsequent degradation of p27Kip1 mediated by Jab1/CSN5 and the COP9 signalosome complex. Tomoda K, et al. J Biol Chem, 2002 Jan 18. PMID 11704659
  4. The minimal deneddylase core of the COP9 signalosome excludes the Csn6 MPN- domain. Pick E, et al. PLoS One, 2012. PMID 22956996, Free PMC Article
  5. Unified nomenclature for the COP9 signalosome and its subunits: an essential regulator of development. Deng XW, et al. Trends Genet, 2000 May. PMID 10782111

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC151177, MGC151203

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein deneddylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein deneddylation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of COP9 signalosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of COP9 signalosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of COP9 signalosome ISO
Inferred from Sequence Orthology
more info
  
located_in cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in synaptic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
COP9 signalosome complex subunit 4
Names
COP9 (constitutive photomorphogenic) homolog, subunit 4
COP9 (constitutive photomorphogenic), subunit 4
COP9 complex S4
JAB1-containing signalosome subunit 4
signalosome subunit 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359203.2 → NP_001346132.1  COP9 signalosome complex subunit 4 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AC109196
    UniProtKB/TrEMBL
    Q3TIJ1
    Conserved Domains (3) summary
    COG5071
    Location:20 → 326
    RPN5; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
    pfam18420
    Location:314 → 355
    CSN4_RPN5_eIF3a; CSN4/RPN5/eIF3a helix turn helix domain
    pfam01399
    Location:213 → 311
    PCI; PCI domain

  2. NM_001359204.2 → NP_001346133.1  COP9 signalosome complex subunit 4 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AC109196
    UniProtKB/TrEMBL
    Q3TIJ1
    Conserved Domains (3) summary
    COG5071
    Location:20 → 326
    RPN5; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
    pfam18420
    Location:314 → 355
    CSN4_RPN5_eIF3a; CSN4/RPN5/eIF3a helix turn helix domain
    pfam01399
    Location:213 → 311
    PCI; PCI domain

  3. NM_001425473.1 → NP_001412402.1  COP9 signalosome complex subunit 4 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC109196
    UniProtKB/TrEMBL
    Q3TIJ1

  4. NM_001425474.1 → NP_001412403.1  COP9 signalosome complex subunit 4 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC109196
    UniProtKB/TrEMBL
    Q3TIJ1

  5. NM_012001.3 → NP_036131.1  COP9 signalosome complex subunit 4 isoform a

    See identical proteins and their annotated locations for NP_036131.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC109196
    Consensus CDS
    CCDS19463.1
    UniProtKB/Swiss-Prot
    O88544
    UniProtKB/TrEMBL
    Q14AI7, Q3TIJ1
    Related
    ENSMUSP00000048416.9, ENSMUST00000045993.15
    Conserved Domains (3) summary
    COG5071
    Location:71 → 377
    RPN5; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
    pfam18420
    Location:365 → 406
    CSN4_RPN5_eIF3a; CSN4/RPN5/eIF3a helix turn helix domain
    pfam01399
    Location:264 → 362
    PCI; PCI domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    100666223..100695668
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165149.1 → XP_036021042.1  COP9 signalosome complex subunit 4 isoform X3

    UniProtKB/TrEMBL
    D3YV99
    Related
    ENSMUSP00000114585.2, ENSMUST00000151414.8
    Conserved Domains (2) summary
    COG5071
    Location:20 → 170
    RPN5; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
    pfam18420
    Location:247 → 288
    CSN4_RPN5_eIF3a; CSN4/RPN5/eIF3a helix turn helix domain

  2. XM_006534953.4 → XP_006535016.1  COP9 signalosome complex subunit 4 isoform X1

    See identical proteins and their annotated locations for XP_006535016.1

    UniProtKB/TrEMBL
    Q3TIJ1
    Conserved Domains (3) summary
    COG5071
    Location:20 → 326
    RPN5; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
    pfam18420
    Location:314 → 355
    CSN4_RPN5_eIF3a; CSN4/RPN5/eIF3a helix turn helix domain
    pfam01399
    Location:213 → 311
    PCI; PCI domain

  3. XM_036165147.1 → XP_036021040.1  COP9 signalosome complex subunit 4 isoform X1

    UniProtKB/TrEMBL
    Q3TIJ1
    Conserved Domains (3) summary
    COG5071
    Location:20 → 326
    RPN5; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
    pfam18420
    Location:314 → 355
    CSN4_RPN5_eIF3a; CSN4/RPN5/eIF3a helix turn helix domain
    pfam01399
    Location:213 → 311
    PCI; PCI domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88544.1 GenPept UniProtKB/Swiss-Prot:O88544

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