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Serpina5 serine (or cysteine) peptidase inhibitor, clade A, member 5 [ Mus musculus (house mouse) ]

Gene ID: 268591, updated on 12-May-2024

Summary

Official Symbol
Serpina5provided by MGI
Official Full Name
serine (or cysteine) peptidase inhibitor, clade A, member 5provided by MGI
Primary source
MGI:MGI:107817
See related
Ensembl:ENSMUSG00000041550 AllianceGenome:MGI:107817
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pci; PAI-3; 4933415L04
Summary
Predicted to enable several functions, including enzyme binding activity; phosphatidylcholine binding activity; and retinoic acid binding activity. Involved in spermatogenesis. Predicted to be located in several cellular components, including extracellular exosome; platelet dense tubular network; and secretory granule. Predicted to be part of several cellular components, including protein C inhibitor-KLK3 complex; protein C inhibitor-PLAT complex; and protein C inhibitor-PLAU complex. Predicted to be active in extracellular space. Is expressed in several structures, including epithelium; genitourinary system; gut; musculoskeletal system; and skin. Orthologous to human SERPINA5 (serpin family A member 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in ovary adult (RPKM 21.0), testis adult (RPKM 16.6) and 2 other tissues See more
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Genomic context

See Serpina5 in Genome Data Viewer
Location:
12 E; 12 53.3 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (104065572..104072397)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (104099313..104106138)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 Neighboring gene predicted gene, 31271 Neighboring gene serine (or cysteine) peptidase inhibitor, clade A, member 4, pseudogene 1 Neighboring gene serine (or cysteine) peptidase inhibitor, clade A, member 3A Neighboring gene serine (or cysteine) peptidase inhibitor, clade A, member 3B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acrosin binding ISO
Inferred from Sequence Orthology
more info
 
enables peptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylcholine binding ISO
Inferred from Sequence Orthology
more info
 
enables protease binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables retinoic acid binding ISO
Inferred from Sequence Orthology
more info
 
enables serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables serine-type endopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in negative regulation of endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of hydrolase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of proteolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in acrosomal membrane ISO
Inferred from Sequence Orthology
more info
 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in platelet alpha granule ISO
Inferred from Sequence Orthology
more info
 
located_in platelet dense tubular network ISO
Inferred from Sequence Orthology
more info
 
part_of protein C inhibitor-KLK3 complex ISO
Inferred from Sequence Orthology
more info
 
part_of protein C inhibitor-PLAT complex ISO
Inferred from Sequence Orthology
more info
 
part_of protein C inhibitor-PLAU complex ISO
Inferred from Sequence Orthology
more info
 
part_of protein C inhibitor-TMPRSS11E complex ISO
Inferred from Sequence Orthology
more info
 
part_of protein C inhibitor-TMPRSS7 complex ISO
Inferred from Sequence Orthology
more info
 
part_of protein C inhibitor-coagulation factor V complex ISO
Inferred from Sequence Orthology
more info
 
part_of protein C inhibitor-coagulation factor XI complex ISO
Inferred from Sequence Orthology
more info
 
part_of protein C inhibitor-coagulation factor Xa complex ISO
Inferred from Sequence Orthology
more info
 
part_of protein C inhibitor-plasma kallikrein complex ISO
Inferred from Sequence Orthology
more info
 
part_of protein C inhibitor-thrombin complex ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
plasma serine protease inhibitor
Names
PAI3
alpha-1 antiproteinase
antitrypsin
plasminogen activator inhibitor-3
protein C inhibitor
serine (or cysteine) proteinase inhibitor, clade A, member 5
serpin A5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172953.3NP_766541.2  plasma serine protease inhibitor precursor

    See identical proteins and their annotated locations for NP_766541.2

    Status: VALIDATED

    Source sequence(s)
    AK077160, AK087714
    Consensus CDS
    CCDS26146.1
    UniProtKB/Swiss-Prot
    P70458, Q5BKQ8, Q8BU50
    UniProtKB/TrEMBL
    Q8BVN1
    Related
    ENSMUSP00000021495.4, ENSMUST00000021495.4
    Conserved Domains (1) summary
    cd19553
    Location:42405
    serpinA5_PCI; serpin family A member 5, protein C inhibitor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    104065572..104072397
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515916.2XP_006515979.1  plasma serine protease inhibitor isoform X1

    See identical proteins and their annotated locations for XP_006515979.1

    UniProtKB/Swiss-Prot
    P70458, Q5BKQ8, Q8BU50
    UniProtKB/TrEMBL
    Q8BVN1
    Conserved Domains (1) summary
    cd19553
    Location:42405
    serpinA5_PCI; serpin family A member 5, protein C inhibitor