U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Meioc meiosis specific with coiled-coil domain [ Mus musculus (house mouse) ]

Gene ID: 268491, updated on 8-Feb-2024

Summary

Official Symbol
Meiocprovided by MGI
Official Full Name
meiosis specific with coiled-coil domainprovided by MGI
Primary source
MGI:MGI:2686410
See related
Ensembl:ENSMUSG00000051455 AllianceGenome:MGI:2686410
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm663; Gm1564
Summary
Involved in several processes, including gamete generation; germline cell cycle switching, mitotic to meiotic cell cycle; and synaptonemal complex assembly. Located in cytoplasm and nucleus. Is expressed in meiotic germ cell of ovary; ovary; spermatocyte; and testis. Orthologous to human MEIOC (meiosis specific with coiled-coil domain). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 6.3) and limb E14.5 (RPKM 0.2) See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Meioc in Genome Data Viewer
Location:
11 E1; 11 66.48 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (102556177..102573066)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (102665351..102682240)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2810433D01 gene Neighboring gene proteasome (prosome, macropain) subunit, beta type 5, pseudogene Neighboring gene STARR-seq mESC enhancer starr_30817 Neighboring gene coiled-coil domain containing 43 Neighboring gene STARR-seq mESC enhancer starr_30819 Neighboring gene DBF4 zinc finger B Neighboring gene proteasome (prosome, macropain) subunit, alpha type 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in chromosome organization involved in meiotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in double-strand break repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in female meiosis I IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in female meiosis I IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in germline cell cycle switching, mitotic to meiotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mRNA stabilization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mRNA stabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in male meiosis I IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in male meiosis I IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in metaphase chromosome alignment IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in oocyte development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in spermatid development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synaptonemal complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
meiosis-specific coiled-coil domain-containing protein MEIOC
Names
meiosis-specific with coiled-coil domain protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127576.2NP_001121048.1  meiosis-specific coiled-coil domain-containing protein MEIOC

    See identical proteins and their annotated locations for NP_001121048.1

    Status: VALIDATED

    Source sequence(s)
    AK131737, AK163979, AL672269, BB610289, BG083749, CJ046726
    Consensus CDS
    CCDS48945.1
    UniProtKB/Swiss-Prot
    A2AG06, Q3V2K8
    Related
    ENSMUSP00000097947.4, ENSMUST00000100378.4
    Conserved Domains (1) summary
    pfam15189
    Location:757922
    DUF4582; Domain of unknown function (DUF4582)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    102556177..102573066
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533415.2XP_006533478.1  meiosis-specific coiled-coil domain-containing protein MEIOC isoform X1

    Conserved Domains (1) summary
    pfam15189
    Location:737902
    MEIOC; Meiosis-specific coiled-coil domain-containing protein MEIOC
  2. XM_006533416.3XP_006533479.1  meiosis-specific coiled-coil domain-containing protein MEIOC isoform X2

    Conserved Domains (1) summary
    pfam15189
    Location:165330
    MEIOC; Meiosis-specific coiled-coil domain-containing protein MEIOC