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Ahsa2 AHA1, activator of heat shock protein ATPase 2 [ Mus musculus (house mouse) ]

Gene ID: 268390, updated on 5-Aug-2022

Summary

Official Symbol
Ahsa2provided by MGI
Official Full Name
AHA1, activator of heat shock protein ATPase 2provided by MGI
Primary source
MGI:MGI:1916133
See related
Ensembl:ENSMUSG00000020288 AllianceGenome:MGI:1916133
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable ATPase activator activity. Predicted to be involved in positive regulation of ATPase activity and protein folding. Predicted to be active in cytosol. Orthologous to human AHSA2P (activator of HSP90 ATPase homolog 2, pseudogene). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 24.7), CNS E14 (RPKM 23.2) and 26 other tissues See more
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Genomic context

See Ahsa2 in Genome Data Viewer
Location:
11; 11 A3.2
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (23437882..23448045, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (23487882..23498045, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (23387882..23397946, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene exportin 1 Neighboring gene ubiquitin specific peptidase 34 Neighboring gene RIKEN cDNA 1700030C12 gene Neighboring gene predicted gene, 22753 Neighboring gene RIKEN cDNA 1700093K21 gene Neighboring gene selenoprotein K, pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3) 
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ36626, 1110064P04Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables Hsp90 protein binding IEA
Inferred from Electronic Annotation
more info
 
enables chaperone binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in positive regulation of ATP-dependent activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
activator of 90 kDa heat shock protein ATPase homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290654.1NP_001277583.1  activator of 90 kDa heat shock protein ATPase homolog 2 isoform 2

    See identical proteins and their annotated locations for NP_001277583.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in its 5' UTR and uses a downstream AUG, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK034661, AK137116, CJ147821
    Consensus CDS
    CCDS70149.1
    UniProtKB/Swiss-Prot
    Q8N9S3
    Related
    ENSMUSP00000105166.2, ENSMUST00000109539.8
    Conserved Domains (2) summary
    cd08892
    Location:154277
    SRPBCC_Aha1; Putative hydrophobic ligand-binding SRPBCC domain of the Hsp90 co-chaperone Aha1 and related proteins
    smart01000
    Location:1110
    Aha1_N; Activator of Hsp90 ATPase, N-terminal
  2. NM_001290655.1NP_001277584.1  activator of 90 kDa heat shock protein ATPase homolog 2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, which leads to a frameshift, compared to variant 1. The encoded isoform (3) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK034661, AK137116, AL672049, CJ147821
    UniProtKB/Swiss-Prot
    Q8N9S3
    Conserved Domains (2) summary
    smart01000
    Location:29158
    Aha1_N; Activator of Hsp90 ATPase, N-terminal
    cl14643
    Location:202274
    SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
  3. NM_172391.4NP_765979.3  activator of 90 kDa heat shock protein ATPase homolog 2 isoform 1

    See identical proteins and their annotated locations for NP_765979.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK034661, AK137116, CJ147821
    Consensus CDS
    CCDS24476.1
    UniProtKB/Swiss-Prot
    Q8CBI4, Q8N9S3
    Related
    ENSMUSP00000020529.7, ENSMUST00000020529.13
    Conserved Domains (3) summary
    cd08892
    Location:202325
    SRPBCC_Aha1; Putative hydrophobic ligand-binding SRPBCC domain of the Hsp90 co-chaperone Aha1 and related proteins
    smart01000
    Location:29158
    Aha1_N; Activator of Hsp90 ATPase, N-terminal
    COG5580
    Location:20321
    COG5580; Activator of HSP90 ATPase [Posttranslational modification, protein turnover, chaperones]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    23437882..23448045 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246029.2XP_030101889.1  activator of 90 kDa heat shock protein ATPase homolog 2 isoform X3

    Conserved Domains (1) summary
    cd08892
    Location:40163
    SRPBCC_Aha1; Putative hydrophobic ligand-binding SRPBCC domain of the Hsp90 co-chaperone Aha1 and related proteins
  2. XM_030246028.2XP_030101888.1  activator of 90 kDa heat shock protein ATPase homolog 2 isoform X1

    Conserved Domains (2) summary
    smart01000
    Location:1110
    Aha1_N; Activator of Hsp90 ATPase, N-terminal
    cl14643
    Location:154226
    SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
  3. XM_011243722.3XP_011242024.1  activator of 90 kDa heat shock protein ATPase homolog 2 isoform X2

    See identical proteins and their annotated locations for XP_011242024.1

    Conserved Domains (1) summary
    smart01000
    Location:29157
    Aha1_N; Activator of Hsp90 ATPase, N-terminal

RNA

  1. XR_003949450.2 RNA Sequence

  2. XR_003949448.1 RNA Sequence

  3. XR_003949449.2 RNA Sequence

  4. XR_004936969.1 RNA Sequence