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Snx17 sorting nexin 17 [ Mus musculus (house mouse) ]

Gene ID: 266781, updated on 2-Nov-2024

Summary

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Official Symbol
Snx17provided by MGI
Official Full Name
sorting nexin 17provided by MGI
Primary source
MGI:MGI:2387801
See related
Ensembl:ENSMUSG00000029146 AllianceGenome:MGI:2387801
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0064; D5Ertd260e; b2b1625.1Clo; 5830447M19Rik
Summary
Predicted to enable low-density lipoprotein particle receptor binding activity and phosphatidylinositol binding activity. Acts upstream of or within circulatory system development; kidney development; and receptor-mediated endocytosis. Located in endosome. Is expressed in cerebral cortex ventricular layer and cortical plate. Orthologous to human SNX17 (sorting nexin 17). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in ovary adult (RPKM 43.6), genital fat pad adult (RPKM 40.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Snx17 in Genome Data Viewer
Location:
5 B1; 5 17.26 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (31350634..31356244)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (31193262..31198900)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene general transcription factor IIIC, polypeptide 2, beta Neighboring gene STARR-seq mESC enhancer starr_12767 Neighboring gene eukaryotic translation initiation factor 2B, subunit 4 delta Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:31495236-31495423 Neighboring gene zinc finger protein 513 Neighboring gene protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform Neighboring gene STARR-seq mESC enhancer starr_12768

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Sorting nexin 17 increases low-density lipoprotein receptor-related protein 4 membrane expression: A novel mechanism of acetylcholine receptor aggregation in myasthenia gravis. He X, et al. Front Immunol, 2022. PMID 36311763, Free PMC Article
  2. Sorting nexin 17 facilitates LRP recycling in the early endosome. van Kerkhof P, et al. EMBO J, 2005 Aug 17. PMID 16052210, Free PMC Article
  3. SNX17 Mediates Dendritic Spine Maturation via p140Cap. Cui Q, et al. Mol Neurobiol, 2024 Mar. PMID 37704928
  4. Sorting nexin 17 (SNX17) links endosomal sorting to Eps15 homology domain protein 1 (EHD1)-mediated fission machinery. Dhawan K, et al. J Biol Chem, 2020 Mar 20. PMID 32041776, Free PMC Article
  5. Sorting nexin 17 prevents lysosomal degradation of β1 integrins by binding to the β1-integrin tail. Böttcher RT, et al. Nat Cell Biol, 2012 May 6. PMID 22561348

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SNX17 Mediates Dendritic Spine Maturation via p140Cap.
    Title: SNX17 Mediates Dendritic Spine Maturation via p140Cap.
  2. Sorting nexin 17 increases low-density lipoprotein receptor-related protein 4 membrane expression: A novel mechanism of acetylcholine receptor aggregation in myasthenia gravis.
    Title: Sorting nexin 17 increases low-density lipoprotein receptor-related protein 4 membrane expression: A novel mechanism of acetylcholine receptor aggregation in myasthenia gravis.
  3. Sorting nexin 17 (SNX17) links endosomal sorting to Eps15 homology domain protein 1 (EHD1)-mediated fission machinery.
    Title: Sorting nexin 17 (SNX17) links endosomal sorting to Eps15 homology domain protein 1 (EHD1)-mediated fission machinery.
  4. results identify SNX17 as a beta1-integrin-tail-binding protein that interacts with the free Kindlin-binding site in endosomes to stabilize beta1 integrins, resulting in their recycling to the cell surface where they can be reused
    Title: Sorting nexin 17 prevents lysosomal degradation of β1 integrins by binding to the β1-integrin tail.
  5. SNX17 regulates amyloid precursor protein trafficking and processing in the early endosomes
    Title: Adaptor protein sorting nexin 17 regulates amyloid precursor protein trafficking and processing in the early endosomes.
  6. results identify SNX17 as a novel adaptor protein for LDLR family members and define a novel mechanism for modulation of their endocytic activity (SNX17; sorting nexin 17)
    Title: The PX-domain protein SNX17 interacts with members of the LDL receptor family and modulates endocytosis of the LDL receptor.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables low-density lipoprotein particle receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables low-density lipoprotein particle receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within aorta development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cardiac septum development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within coronary vasculature development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endocytic recycling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytic recycling ISO
Inferred from Sequence Orthology
more info
  
involved_in endocytic recycling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within kidney development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within receptor-mediated endocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in early endosome IEA
Inferred from Electronic Annotation
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
located_in endosome IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in endosome membrane ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
sorting nexin-17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418276.1 → NP_001405205.1  sorting nexin-17 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC114619

  2. NM_001418277.1 → NP_001405206.1  sorting nexin-17 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC114619

  3. NM_001418278.1 → NP_001405207.1  sorting nexin-17 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC114619

  4. NM_001418279.1 → NP_001405208.1  sorting nexin-17 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC114619

  5. NM_153680.3 → NP_710147.1  sorting nexin-17 isoform a

    See identical proteins and their annotated locations for NP_710147.1

    Status: VALIDATED

    Source sequence(s)
    AC114619
    Consensus CDS
    CCDS19177.1
    UniProtKB/Swiss-Prot
    Q8BVL3, Q8R0N8
    Related
    ENSMUSP00000031029.9, ENSMUST00000031029.15
    Conserved Domains (3) summary
    cd06885
    Location:2 → 106
    PX_SNX17_31; The phosphoinositide binding Phox Homology domain of Sorting Nexins 17 and 31
    cd13337
    Location:269 → 388
    FERM-like_C_SNX17; Atypical FERM-like domain C-lobe of Sorting nexin 17
    cl00155
    Location:116 → 186
    UBQ; Ubiquitin-like proteins

RNA

  1. NR_184707.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC114619
    Related
    ENSMUST00000200730.4

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    31350634..31356244
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BVL3.2 GenPept UniProtKB/Swiss-Prot:Q8BVL3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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