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MAGEA2B MAGE family member A2B [ Homo sapiens (human) ]

Gene ID: 266740, updated on 22-Jun-2021

Summary

Official Symbol
MAGEA2Bprovided by HGNC
Official Full Name
MAGE family member A2Bprovided by HGNC
Primary source
HGNC:HGNC:19340
See related
Ensembl:ENSG00000183305 MIM:300549
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT1.2; MAGE2
Summary
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. This gene has two identical copies at different loci. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward testis (RPKM 2.9) See more
Orthologs
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Genomic context

See MAGEA2B in Genome Data Viewer
Location:
Xq28
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (152714586..152718607)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (151883075..151887096)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene MAGE family member A3 Neighboring gene CSAG family member 2 Neighboring gene chondrosarcoma associated gene 1 Neighboring gene MAGE family member A12 Neighboring gene CSAG family member 4 (pseudogene)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC16973

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables histone deacetylase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables histone deacetylase binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in PML body IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
melanoma-associated antigen 2
Names
MAGE-2 antigen
cancer/testis antigen 1.2
melanoma antigen 2
melanoma antigen family A, 2B
melanoma antigen family A2B
melanoma antigen, family A, 2, copy b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321400.1NP_001308329.1  melanoma-associated antigen 2

    Status: REVIEWED

    Description
    Transcript Variant: Variants 1 through 6 encode the same protein.
    Source sequence(s)
    AC244102
    Consensus CDS
    CCDS76046.1
    UniProtKB/Swiss-Prot
    P43356
    UniProtKB/TrEMBL
    A0A024RC17
    Conserved Domains (2) summary
    pfam01454
    Location:116280
    MAGE; MAGE family
    pfam12440
    Location:594
    MAGE_N; Melanoma associated antigen family N terminal
  2. NM_001321401.1NP_001308330.1  melanoma-associated antigen 2

    Status: REVIEWED

    Description
    Transcript Variant: Variants 1 through 6 encode the same protein.
    Source sequence(s)
    AC244102
    Consensus CDS
    CCDS76046.1
    UniProtKB/Swiss-Prot
    P43356
    UniProtKB/TrEMBL
    A0A024RC17
    Conserved Domains (2) summary
    pfam01454
    Location:116280
    MAGE; MAGE family
    pfam12440
    Location:594
    MAGE_N; Melanoma associated antigen family N terminal
  3. NM_001321402.1NP_001308331.1  melanoma-associated antigen 2

    Status: REVIEWED

    Description
    Transcript Variant: Variants 1 through 6 encode the same protein.
    Source sequence(s)
    AC244102
    Consensus CDS
    CCDS76046.1
    UniProtKB/Swiss-Prot
    P43356
    UniProtKB/TrEMBL
    A0A024RC17
    Related
    ENSP00000333487.2, ENST00000331220.6
    Conserved Domains (2) summary
    pfam01454
    Location:116280
    MAGE; MAGE family
    pfam12440
    Location:594
    MAGE_N; Melanoma associated antigen family N terminal
  4. NM_001321403.1NP_001308332.1  melanoma-associated antigen 2

    Status: REVIEWED

    Description
    Transcript Variant: Variants 1 through 6 encode the same protein.
    Source sequence(s)
    AC244102
    Consensus CDS
    CCDS76046.1
    UniProtKB/Swiss-Prot
    P43356
    UniProtKB/TrEMBL
    A0A024RC17
    Conserved Domains (2) summary
    pfam01454
    Location:116280
    MAGE; MAGE family
    pfam12440
    Location:594
    MAGE_N; Melanoma associated antigen family N terminal
  5. NM_001321404.1NP_001308333.1  melanoma-associated antigen 2

    Status: REVIEWED

    Description
    Transcript Variant: Variants 1 through 6 encode the same protein.
    Source sequence(s)
    AC244102
    Consensus CDS
    CCDS76046.1
    UniProtKB/Swiss-Prot
    P43356
    UniProtKB/TrEMBL
    A0A024RC17
    Conserved Domains (2) summary
    pfam01454
    Location:116280
    MAGE; MAGE family
    pfam12440
    Location:594
    MAGE_N; Melanoma associated antigen family N terminal
  6. NM_001386132.1NP_001373061.1  melanoma-associated antigen 2

    Status: REVIEWED

    Source sequence(s)
    AC244102
    Related
    ENSP00000507594.1, ENST00000682532.1
    Conserved Domains (2) summary
    pfam01454
    Location:116280
    MAGE; MAGE family
    pfam12440
    Location:594
    MAGE_N; Melanoma associated antigen family N terminal
  7. NM_153488.4NP_705692.1  melanoma-associated antigen 2

    See identical proteins and their annotated locations for NP_705692.1

    Status: REVIEWED

    Description
    Transcript Variant: Variants 1 through 6 encode the same protein.
    Source sequence(s)
    AC244102
    Consensus CDS
    CCDS76046.1
    UniProtKB/Swiss-Prot
    P43356
    UniProtKB/TrEMBL
    A0A024RC17
    Related
    ENSP00000359316.2, ENST00000370293.6
    Conserved Domains (2) summary
    pfam01454
    Location:116280
    MAGE; MAGE family
    pfam12440
    Location:594
    MAGE_N; Melanoma associated antigen family N terminal

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    152714586..152718607
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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