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Cyb5r4 cytochrome b5 reductase 4 [ Mus musculus (house mouse) ]

Gene ID: 266690, updated on 12-May-2024

Summary

Official Symbol
Cyb5r4provided by MGI
Official Full Name
cytochrome b5 reductase 4provided by MGI
Primary source
MGI:MGI:2386848
See related
Ensembl:ENSMUSG00000032872 AllianceGenome:MGI:2386848
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
b5b5r; B5+B5R; Ncb5or; b5/b5r; Cb5cb5r; 2810034J18Rik
Summary
Enables cytochrome-b5 reductase activity, acting on NAD(P)H. Acts upstream of or within several processes, including glucose homeostasis; insulin secretion; and response to antibiotic. Located in endoplasmic reticulum. Is expressed in metanephros; nervous system; sensory organ; submandibular gland primordium; and thymus primordium. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human CYB5R4 (cytochrome b5 reductase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 10.7), bladder adult (RPKM 10.6) and 28 other tissues See more
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Genomic context

Location:
9 E3.1; 9 46.69 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (86904082..86959827)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (87022008..87077774)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39389 Neighboring gene STARR-seq mESC enhancer starr_24843 Neighboring gene predicted gene, 36539 Neighboring gene STARR-positive B cell enhancer ABC_E2909 Neighboring gene STARR-positive B cell enhancer ABC_E6782 Neighboring gene ripply transcriptional repressor 2 Neighboring gene predicted gene, 57850 Neighboring gene predicted gene 8282 Neighboring gene melanocortin 2 receptor accessory protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NADPH-hemoprotein reductase activity ISO
Inferred from Sequence Orthology
more info
 
enables cytochrome-b5 reductase activity, acting on NAD(P)H IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cytochrome-b5 reductase activity, acting on NAD(P)H IDA
Inferred from Direct Assay
more info
PubMed 
enables cytochrome-b5 reductase activity, acting on NAD(P)H ISO
Inferred from Sequence Orthology
more info
PubMed 
enables flavin adenine dinucleotide binding ISO
Inferred from Sequence Orthology
more info
 
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables heme binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in NADP metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heme metabolic process ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to antibiotic IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in superoxide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in superoxide metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cytochrome b5 reductase 4
Names
N-terminal cytochrome b5 and cytochrome b5 oxidoreductase domain-containing protein
NADPH cytochrome B5 oxidoreductase
cb5/cb5R
cytochrome b-type NAD(P)H oxidoreductase
flavohemoprotein b5/b5R
NP_001346891.1
NP_077157.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359962.1NP_001346891.1  cytochrome b5 reductase 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC156793, CO801035
    Conserved Domains (3) summary
    cd06183
    Location:285475
    cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
    cd06490
    Location:177263
    p23_NCB5OR; p23_like domain found in NAD(P)H cytochrome b5 (NCB5) oxidoreductase (OR) and similar proteins. NCB5OR is widely expressed in human organs and tissues and is localized in the ER (endoplasmic reticulum). It appears to play a critical role in maintaining ...
    pfam00173
    Location:58130
    Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
  2. NM_024195.2NP_077157.2  cytochrome b5 reductase 4 isoform 1

    See identical proteins and their annotated locations for NP_077157.2

    Status: VALIDATED

    Source sequence(s)
    AK090159, CO801035
    Consensus CDS
    CCDS40716.2
    UniProtKB/Swiss-Prot
    E9Q129, Q3TDX8, Q3TJH3, Q3U012, Q6VXY4, Q6VXY5, Q8BJV8, Q8BTI5, Q8R3H8, Q99LY4, Q99P29
    Related
    ENSMUSP00000126119.3, ENSMUST00000168529.9
    Conserved Domains (3) summary
    cd06183
    Location:285526
    cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
    cd06490
    Location:177263
    p23_NCB5OR; p23_like domain found in NAD(P)H cytochrome b5 (NCB5) oxidoreductase (OR) and similar proteins. NCB5OR is widely expressed in human organs and tissues and is localized in the ER (endoplasmic reticulum). It appears to play a critical role in maintaining ...
    pfam00173
    Location:56128
    Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    86904082..86959827
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)