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MYEOV myeloma overexpressed [ Homo sapiens (human) ]

Gene ID: 26579, updated on 3-Dec-2023

Summary

Official Symbol
MYEOVprovided by HGNC
Official Full Name
myeloma overexpressedprovided by HGNC
Primary source
HGNC:HGNC:7563
See related
Ensembl:ENSG00000172927 MIM:605625; AllianceGenome:HGNC:7563
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OCIM
Expression
Biased expression in stomach (RPKM 11.5), esophagus (RPKM 10.9) and 5 other tissues See more
Orthologs
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Genomic context

See MYEOV in Genome Data Viewer
Location:
11q13.3
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (69294155..69297287)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (69311284..69314452)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (69061622..69064754)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369367 Neighboring gene uncharacterized LOC105369368 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5154 Neighboring gene VISTA enhancer hs2073 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69060193-69060744 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:69064594-69065793 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:69066990-69067178 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69078345-69078844 Neighboring gene interferon induced transmembrane protein 9 pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:69088091-69088958 Neighboring gene uncharacterized LOC105369370 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5158 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69153613-69154114 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69154115-69154614 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69157262-69158194 Neighboring gene MPRA-validated peak1324 silencer

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association scan for variants associated with early-onset prostate cancer.
EBI GWAS Catalog
Genome-wide association study identifies five new breast cancer susceptibility loci.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
myeloma-overexpressed gene protein
Names
myeloma overexpressed (in a subset of t(11;14) positive multiple myelomas)
myeloma overexpressed gene (in a subset of t(11;14) positive multiple myelomas)
oncogene in multiple myeloma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001293291.2NP_001280220.1  myeloma-overexpressed gene protein isoform 1

    See identical proteins and their annotated locations for NP_001280220.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Both variants 1 and 2 encode the same isoform 1.
    Source sequence(s)
    AK026148, AK290121, BC011815, CB147813
    Consensus CDS
    CCDS8190.1
    UniProtKB/Swiss-Prot
    Q96EZ4, Q9UGN6, Q9UGN7
    UniProtKB/TrEMBL
    A8K256
    Related
    ENSP00000412482.2, ENST00000441339.3
  2. NM_001293294.2NP_001280223.1  myeloma-overexpressed gene protein isoform 2

    See identical proteins and their annotated locations for NP_001280223.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an internal splice junction, which results in translation initiation at a downstream AUG start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. Variants 3, 4, 5, and 6 all encode the same isoform (2).
    Source sequence(s)
    AJ223366, AK290121, BC011815, CB147813
    Consensus CDS
    CCDS73340.1
    UniProtKB/TrEMBL
    A8K256, F5H0B3
    Related
    ENST00000535653.1
  3. NM_001293296.2NP_001280225.1  myeloma-overexpressed gene protein isoform 2

    See identical proteins and their annotated locations for NP_001280225.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has an alternate splice site in the 5' UTR, which results in translation initiation at a downstream AUG start codon, and it also lacks an internal splice junction, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. Variants 3, 4, 5, and 6 all encode the same isoform (2).
    Source sequence(s)
    AK026148, AK290121, BC011815, CB147813
    Consensus CDS
    CCDS73340.1
    UniProtKB/TrEMBL
    A8K256, F5H0B3
    Related
    ENSP00000438100.1, ENST00000535407.1
  4. NM_001300923.2NP_001287852.1  myeloma-overexpressed gene protein isoform 2

    See identical proteins and their annotated locations for NP_001287852.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence and uses a downstream start codon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1. Variants 3, 4, 5, and 6 all encode the same isoform (2).
    Source sequence(s)
    AK026148, AK290121, BC011815, CB147813, DA377031
    Consensus CDS
    CCDS73340.1
    UniProtKB/TrEMBL
    A8K256, F5H0B3
  5. NM_001300924.2NP_001287853.1  myeloma-overexpressed gene protein isoform 2

    See identical proteins and their annotated locations for NP_001287853.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence and uses a downstream start codon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1. Variants 3, 4, 5, and 6 all encode the same isoform (2).
    Source sequence(s)
    AK026148, AK290121, BC011815, CB147813, DA902417
    Consensus CDS
    CCDS73340.1
    UniProtKB/TrEMBL
    A8K256, F5H0B3
  6. NM_138768.4NP_620123.2  myeloma-overexpressed gene protein isoform 1

    See identical proteins and their annotated locations for NP_620123.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate splice site in the 5' UTR, and encodes the same isoform 1, compared to variant 1.
    Source sequence(s)
    AJ223366, AK290121, BC011815, CB147813
    Consensus CDS
    CCDS8190.1
    UniProtKB/Swiss-Prot
    Q96EZ4, Q9UGN6, Q9UGN7
    UniProtKB/TrEMBL
    A8K256
    Related
    ENSP00000308330.3, ENST00000308946.3

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    69294155..69297287
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047426763.1XP_047282719.1  myeloma-overexpressed gene protein isoform X1

    UniProtKB/Swiss-Prot
    Q96EZ4, Q9UGN6, Q9UGN7
    UniProtKB/TrEMBL
    A8K256

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    69311284..69314452
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054368411.1XP_054224386.1  myeloma-overexpressed gene protein isoform X1

    UniProtKB/Swiss-Prot
    Q96EZ4, Q9UGN6, Q9UGN7
    UniProtKB/TrEMBL
    A8K256