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CNNM3 cyclin and CBS domain divalent metal cation transport mediator 3 [ Homo sapiens (human) ]

Gene ID: 26505, updated on 24-Nov-2020

Summary

Official Symbol
CNNM3provided by HGNC
Official Full Name
cyclin and CBS domain divalent metal cation transport mediator 3provided by HGNC
Primary source
HGNC:HGNC:104
See related
Ensembl:ENSG00000168763 MIM:607804
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ACDP3
Expression
Ubiquitous expression in duodenum (RPKM 7.6), small intestine (RPKM 6.3) and 25 other tissues See more
Orthologs

Genomic context

See CNNM3 in Genome Data Viewer
Location:
2q11.2
Exon count:
10
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (96814946..96837109)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (97480950..97501121)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene cyclin and CBS domain divalent metal cation transport mediator 4 Neighboring gene microRNA 3127 Neighboring gene CNNM3 divergent transcript Neighboring gene ankyrin repeat domain 23 Neighboring gene ankyrin repeat domain 39

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20018, DKFZp434I1016

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
ion transport IEA
Inferred from Electronic Annotation
more info
 
transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane HDA PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
metal transporter CNNM3
Names
ancient conserved domain protein 3
ancient conserved domain-containing protein 3
cyclin-M3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017623.5NP_060093.3  metal transporter CNNM3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_060093.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC092636, AK126847
    Consensus CDS
    CCDS2025.1
    UniProtKB/Swiss-Prot
    Q8NE01
    Related
    ENSP00000305449.3, ENST00000305510.4
    Conserved Domains (2) summary
    COG1253
    Location:221467
    TlyC; Hemolysin or related protein, contains CBS domains [General function prediction only]
    cd04590
    Location:323443
    CBS_pair_CorC_HlyC_assoc; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in ...
  2. NM_199078.3NP_951060.1  metal transporter CNNM3 isoform 2 precursor

    See identical proteins and their annotated locations for NP_951060.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame coding exon, compared to variant 1. The resulting isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC092636, AK126847, BC007199
    Consensus CDS
    CCDS2026.1
    UniProtKB/Swiss-Prot
    Q8NE01
    Related
    ENSP00000366260.3, ENST00000377060.7
    Conserved Domains (1) summary
    cd04590
    Location:323408
    CBS_pair_CorC_HlyC_assoc; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    96814946..96837109
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011510957.3XP_011509259.1  metal transporter CNNM3 isoform X1

    Conserved Domains (2) summary
    COG1253
    Location:221467
    TlyC; Hemolysin or related protein, contains CBS domains [General function prediction only]
    cd04590
    Location:323443
    CBS_pair_CorC_HlyC_assoc; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in ...
  2. XM_017003800.2XP_016859289.1  metal transporter CNNM3 isoform X2

RNA

  1. XR_001738702.2 RNA Sequence

  2. XR_001738701.2 RNA Sequence

  3. XR_001738700.2 RNA Sequence

  4. XR_244887.5 RNA Sequence

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