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OR8G1 olfactory receptor family 8 subfamily G member 1 [ Homo sapiens (human) ]

Gene ID: 26494, updated on 10-Dec-2024

Summary

Official Symbol
OR8G1provided by HGNC
Official Full Name
olfactory receptor family 8 subfamily G member 1provided by HGNC
Primary source
HGNC:HGNC:8484
See related
Ensembl:ENSG00000197849 AllianceGenome:HGNC:8484
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OR8G1P; TPCR25; HSTPCR25
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. This family member represents a polymorphic pseudogene, whereby some individuals have a functional allele that encodes a full-length protein, while others have a non-functional allele due to the presence of an early stop codon and a 3' end deletion. [provided by RefSeq, Feb 2014]
Annotation information
Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
Orthologs
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Genomic context

See OR8G1 in Genome Data Viewer
Location:
11q24.2
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (124241095..124254364)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (124269694..124282961)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (124120423..124121287)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724410 Neighboring gene olfactory receptor family 8 subfamily G member 2 pseudogene Neighboring gene olfactory receptor family 8 subfamily G member 7 pseudogene Neighboring gene olfactory receptor family 8 subfamily G member 5 Neighboring gene solute carrier family 5 member 4 pseudogene 1

Genomic regions, transcripts, and products

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables odorant binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables olfactory receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in detection of chemical stimulus involved in sensory perception of smell IEA
Inferred from Electronic Annotation
more info
 
involved_in sensory perception of smell IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in sensory perception of smell NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
olfactory receptor 8G1
Names
olfactory receptor OR11-281
olfactory receptor TPCR25
olfactory receptor, family 8, subfamily G, member 1 pseudogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002905.2NP_001002905.1  olfactory receptor 8G1

    See identical proteins and their annotated locations for NP_001002905.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, coding) represents the longer transcript and encodes the supported protein. It represents the functional allele, as described in PMID: 18674749 and found in the GRCh38 reference genome assembly.
    Source sequence(s)
    AP002965, FO680687
    Consensus CDS
    CCDS73407.1
    UniProtKB/Swiss-Prot
    Q15617, Q8NG88
    UniProtKB/TrEMBL
    A0A126GVX6
    Related
    ENSP00000493289.1, ENST00000641972.1
    Conserved Domains (2) summary
    pfam00001
    Location:41290
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:34305
    7tm_4; Olfactory receptor

RNA

  1. NR_045681.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, non-coding) represents the non-functional allele with an 851-nt deletion and early stop codon that disrupts the coding region, compared to variant 1. This allele is described in PMID: 18674749 and was represented in the previous GRCh37 reference genome assembly.
    Source sequence(s)
    AP002965

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    124241095..124254364
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    124269694..124282961
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_012379.1: Suppressed sequence

    Description
    NM_012379.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.