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PPP1R14B protein phosphatase 1 regulatory inhibitor subunit 14B [ Homo sapiens (human) ]

Gene ID: 26472, updated on 21-Dec-2019

Summary

Official Symbol
PPP1R14Bprovided by HGNC
Official Full Name
protein phosphatase 1 regulatory inhibitor subunit 14Bprovided by HGNC
Primary source
HGNC:HGNC:9057
See related
Ensembl:ENSG00000173457 MIM:601140
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PNG; PHI-1; PLCB3N; SOM172
Expression
Ubiquitous expression in skin (RPKM 28.9), appendix (RPKM 28.1) and 25 other tissues See more
Orthologs

Genomic context

See PPP1R14B in Genome Data Viewer
Location:
11q13.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (64244479..64246943, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (64011951..64014413, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene vascular endothelial growth factor B Neighboring gene Uncharacterized protein LOC114841035 Neighboring gene PPP1R14B antisense RNA 1 Neighboring gene FKBP prolyl isomerase 2 Neighboring gene phospholipase C beta 3 Neighboring gene G protein-coupled receptor 137 Neighboring gene BCL2 associated agonist of cell death

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein serine/threonine phosphatase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein phosphatase 1 regulatory subunit 14B
Names
phospholipase C beta-3 neighboring gene protein
phospholipase C-beta-3 neighbouring gene protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138689.3NP_619634.1  protein phosphatase 1 regulatory subunit 14B

    See identical proteins and their annotated locations for NP_619634.1

    Status: VALIDATED

    Source sequence(s)
    AP001453, BC014522, BC071884, BF155230, BM847221
    Consensus CDS
    CCDS31596.1
    UniProtKB/Swiss-Prot
    Q96C90
    Related
    ENSP00000310117.3, ENST00000309318.8
    Conserved Domains (1) summary
    pfam05361
    Location:51147
    PP1_inhibitor; PKC-activated protein phosphatase-1 inhibitor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    64244479..64246943 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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