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Psmb3 proteasome (prosome, macropain) subunit, beta type 3 [ Mus musculus (house mouse) ]

Gene ID: 26446, updated on 8-Feb-2024

Summary

Official Symbol
Psmb3provided by MGI
Official Full Name
proteasome (prosome, macropain) subunit, beta type 3provided by MGI
Primary source
MGI:MGI:1347014
See related
Ensembl:ENSMUSG00000069744 AllianceGenome:MGI:1347014
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C10-II
Summary
Predicted to enable endopeptidase activity. Predicted to be involved in proteasomal protein catabolic process. Predicted to act upstream of or within protein catabolic process. Part of proteasome core complex. Is expressed in several structures, including alimentary system; cranial ganglion; gonad; maturing glomerular tuft; and orbito-sphenoid. Orthologous to human PSMB3 (proteasome 20S subunit beta 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in large intestine adult (RPKM 174.6), kidney adult (RPKM 115.8) and 28 other tissues See more
Orthologs
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Genomic context

See Psmb3 in Genome Data Viewer
Location:
11 D; 11 61.07 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (97594260..97604326)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (97703434..97713500)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene polycomb group ring finger 2 Neighboring gene STARR-positive B cell enhancer ABC_E7051 Neighboring gene STARR-positive B cell enhancer ABC_E1430 Neighboring gene nuclear encoded tRNA asparagine 8 (anticodon GTT) Neighboring gene phosphatidylinositol-5-phosphate 4-kinase, type II, beta Neighboring gene microRNA 8102

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC106850

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables endopeptidase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of proteasome complex ISO
Inferred from Sequence Orthology
more info
 
part_of proteasome core complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of proteasome core complex ISO
Inferred from Sequence Orthology
more info
 
part_of proteasome core complex, beta-subunit complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of proteasome core complex, beta-subunit complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
proteasome subunit beta type-3
Names
proteasome chain 13
proteasome component C10-II
proteasome theta chain
NP_036101.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011971.4NP_036101.1  proteasome subunit beta type-3

    See identical proteins and their annotated locations for NP_036101.1

    Status: PROVISIONAL

    Source sequence(s)
    AL596123
    Consensus CDS
    CCDS25328.1
    UniProtKB/Swiss-Prot
    Q9R1P1
    UniProtKB/TrEMBL
    Q545G0
    Related
    ENSMUSP00000099436.5, ENSMUST00000103147.5
    Conserved Domains (1) summary
    cd03759
    Location:6201
    proteasome_beta_type_3; proteasome beta type-3 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    97594260..97604326
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)