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Psg19 pregnancy specific beta-1-glycoprotein 19 [ Mus musculus (house mouse) ]

Gene ID: 26439, updated on 2-Nov-2024

Summary

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Official Symbol
Psg19provided by MGI
Official Full Name
pregnancy specific beta-1-glycoprotein 19provided by MGI
Primary source
MGI:MGI:1347252
See related
Ensembl:ENSMUSG00000004542 AllianceGenome:MGI:1347252
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CGM7; Cea4; Cea-4
Summary
Predicted to be involved in T cell activation and immune response. Predicted to be located in apical plasma membrane and cytosol. Predicted to be active in external side of plasma membrane. Is expressed in labyrinthine zone and spongiotrophoblast. Orthologous to human CEACAM7 (CEA cell adhesion molecule 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward placenta adult (RPKM 50.9) See more
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Genomic context

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See Psg19 in Genome Data Viewer
Location:
7 A3; 7 9.31 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (18523045..18532471, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (18789120..18798546, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene pregnancy-specific beta-1-glycoprotein 22 Neighboring gene STARR-seq mESC enhancer starr_18174 Neighboring gene predicted gene, 24464 Neighboring gene STARR-seq mESC enhancer starr_18175 Neighboring gene synaptonemal complex protein 1, pseudogene 1 Neighboring gene carcinoembryonic antigen-related cell adhesion molecule 1 pseudogene Neighboring gene pregnancy specific beta-1-glycoprotein 17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mapping of murine YACs containing the genes Cea2 and Cea4 after B1-PCR amplification and FISH-analysis. Rettenberger G, et al. Chromosome Res, 1995 Dec. PMID 8581299
  2. Coordinate expression of splice variants of the murine pregnancy-specific glycoprotein (PSG) gene family during placental development. Kromer B, et al. Eur J Biochem, 1996 Dec 1. PMID 8973644
  3. Mouse pregnancy-specific glycoproteins: tissue-specific expression and evidence of association with maternal vasculature. Wynne F, et al. Reproduction, 2006 Apr. PMID 16595723
  4. HOP/NECC1, a novel regulator of mouse trophoblast differentiation. Asanoma K, et al. J Biol Chem, 2007 Aug 17. PMID 17576768
  5. Transient reduction of placental angiogenesis in PAI-1-deficient mice. Labied S, et al. Physiol Genomics, 2011 Feb 24. PMID 21119013

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Clone Names

  • MGC117673

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in T cell activation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in cellular_component ND
No biological Data available
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
pregnancy specific glycoprotein 19
Names
carcinoembryonic antigen 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011964.2 → NP_036094.2  pregnancy specific glycoprotein 19

    See identical proteins and their annotated locations for NP_036094.2

    Status: VALIDATED

    Source sequence(s)
    AA408180, AK145915, AV034276, BC099467
    Consensus CDS
    CCDS20877.1
    UniProtKB/TrEMBL
    P70161, P70162, Q4KL31, Q62054
    Related
    ENSMUSP00000004657.7, ENSMUST00000004657.14
    Conserved Domains (3) summary
    cd05774
    Location:276 → 380
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00408
    Location:400 → 461
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:395 → 472
    IG_like; Immunoglobulin like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    18523045..18532471 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540007.4 → XP_006540070.1  pregnancy specific glycoprotein 19 isoform X1

    Conserved Domains (2) summary
    smart00408
    Location:276 → 337
    IGc2; Immunoglobulin C-2 Type
    cd05774
    Location:152 → 256
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
Nucleotide Protein Strain
Heading Accession and Version

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