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Mapk14 mitogen-activated protein kinase 14 [ Mus musculus (house mouse) ]

Gene ID: 26416, updated on 18-Apr-2024

Summary

Official Symbol
Mapk14provided by MGI
Official Full Name
mitogen-activated protein kinase 14provided by MGI
Primary source
MGI:MGI:1346865
See related
Ensembl:ENSMUSG00000053436 AllianceGenome:MGI:1346865
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p38; Crk1; Mxi2; p38a; CSBP2; Csbp1; PRKM14; PRKM15; p38MAPK; p38alpha; p38-alpha
Summary
Enables MAP kinase activity and NFAT protein binding activity. Involved in several processes, including p38MAPK cascade; positive regulation of cell differentiation; and skeletal system development. Acts upstream of or within several processes, including animal organ development; cell surface receptor signaling pathway; and positive regulation of cell differentiation. Located in several cellular components, including cytosol; mitochondrion; and spindle pole. Is active in glutamatergic synapse. Is expressed in several structures, including brain; early conceptus; epidermis; genitourinary system; and lung. Orthologous to human MAPK14 (mitogen-activated protein kinase 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen adult (RPKM 35.2), thymus adult (RPKM 34.4) and 28 other tissues See more
Orthologs
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Genomic context

Location:
17 A3.3; 17 14.85 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (28910316..28967379)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (28691342..28748405)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_42224 Neighboring gene serine/arginine-rich protein specific kinase 1 Neighboring gene STARR-seq mESC enhancer starr_42228 Neighboring gene solute carrier family 26, member 8 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:28828272-28828381 Neighboring gene G protein subunit gamma 5C Neighboring gene STARR-seq mESC enhancer starr_42232 Neighboring gene STARR-seq mESC enhancer starr_42233 Neighboring gene mitogen-activated protein kinase 13 Neighboring gene STARR-positive B cell enhancer ABC_E167 Neighboring gene predicted gene, 35883 Neighboring gene bromodomain and PHD finger containing, 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (17)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC102436

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables MAP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables MAP kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables NFAT protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables mitogen-activated protein kinase p38 binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity EXP
Inferred from Experiment
more info
PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within DNA damage response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in bone development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cartilage condensation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cell surface receptor protein serine/threonine kinase signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cellular response to UV-B ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in cellular response to lipoteichoic acid ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to tumor necrosis factor IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to vascular endothelial growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to virus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within chondrocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in chondrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within fatty acid oxidation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of glucose import IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within glucose metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipopolysaccharide-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of hippo signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in osteoclast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in p38MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in p38MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within placenta development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of brown fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of cardiac muscle cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of cyclase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of glucose import IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-12 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of myoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of myoblast fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of myotube differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cytokine production involved in inflammatory response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of ossification IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of synaptic membrane adhesion EXP
Inferred from Experiment
more info
PubMed 
involved_in regulation of synaptic membrane adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of synaptic membrane adhesion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in regulation of synaptic membrane adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to dietary excess IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to insulin IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to muramyl dipeptide IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to muscle stretch IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in signal transduction in response to DNA damage ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within skeletal muscle tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within stem cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in stress-activated MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in stress-activated protein kinase signaling cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in stress-induced premature senescence ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within striated muscle cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within_positive_effect tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vascular endothelial growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in glutamatergic synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in spindle pole IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
mitogen-activated protein kinase 14
Names
MAP kinase 14
MAP kinase p38 alpha
MAPK 14
mitogen-activated protein kinase p38 alpha
p38 MAP kinase alpha
p38 MAPK
NP_001161980.1
NP_001161985.1
NP_001161986.1
NP_001344653.1
NP_036081.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168508.1NP_001161980.1  mitogen-activated protein kinase 14 isoform 2

    See identical proteins and their annotated locations for NP_001161980.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate in-frame coding exon compared to variant 1. This results in an isoform (2) of the same size, but with a different 27 aa protein segment compared to isoform 1.
    Source sequence(s)
    AC170998, AI132714, AK133684, CX568915, D83073
    Consensus CDS
    CCDS50048.1
    UniProtKB/TrEMBL
    Q5U421
    Related
    ENSMUSP00000004990.7, ENSMUST00000004990.14
    Conserved Domains (1) summary
    cd07877
    Location:6350
    STKc_p38alpha; Catalytic domain of the Serine/Threonine Kinase, p38alpha Mitogen-Activated Protein Kinase (also called MAPK14)
  2. NM_001168513.1NP_001161985.1  mitogen-activated protein kinase 14 isoform 3

    See identical proteins and their annotated locations for NP_001161985.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' terminal exon compared to variant 1. This results in translation initiation from an in-frame downstream AUG and a shorter isoform (3) compared to isoform 1. Variants 3-5 encode the same isoform (3).
    Source sequence(s)
    AI132714, AK133684, AK151348
    Consensus CDS
    CCDS50049.1
    UniProtKB/Swiss-Prot
    P47811
    Related
    ENSMUSP00000110400.2, ENSMUST00000114752.3
    Conserved Domains (1) summary
    cl21453
    Location:1273
    PKc_like; Protein Kinases, catalytic domain
  3. NM_001168514.1NP_001161986.1  mitogen-activated protein kinase 14 isoform 3

    See identical proteins and their annotated locations for NP_001161986.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an additional exon at the 5' end compared to variant 1. This results in translation initiation from an in-frame downstream AUG and a shorter isoform (3) compared to isoform 1. Variants 3-5 encode the same isoform (3).
    Source sequence(s)
    AC170998, AI132714, AK133684
    Consensus CDS
    CCDS50049.1
    UniProtKB/Swiss-Prot
    P47811
    Related
    ENSMUSP00000110402.2, ENSMUST00000114754.8
    Conserved Domains (1) summary
    cl21453
    Location:1273
    PKc_like; Protein Kinases, catalytic domain
  4. NM_001357724.1NP_001344653.1  mitogen-activated protein kinase 14 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC170998, W66694
    Conserved Domains (1) summary
    cl21453
    Location:1273
    PKc_like; Protein Kinases, catalytic domain
  5. NM_011951.3NP_036081.1  mitogen-activated protein kinase 14 isoform 1

    See identical proteins and their annotated locations for NP_036081.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC170998, AI132714, AK133684
    Consensus CDS
    CCDS28583.1
    UniProtKB/Swiss-Prot
    B2KF37, B2KF38, O08666, P47811, Q3U6R5, Q3UZS3, Q8C289, Q9JLV8, Q9QZ80
    Related
    ENSMUSP00000061958.9, ENSMUST00000062694.16
    Conserved Domains (1) summary
    cd07877
    Location:6350
    STKc_p38alpha; Catalytic domain of the Serine/Threonine Kinase, p38alpha Mitogen-Activated Protein Kinase (also called MAPK14)

RNA

  1. NR_189138.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC170998

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    28910316..28967379
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)