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Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) [ Mus musculus (house mouse) ]

Gene ID: 26357, updated on 1-Jul-2018
Official Symbol
Abcg2provided by MGI
Official Full Name
ATP binding cassette subfamily G member 2 (Junior blood group)provided by MGI
Primary source
MGI:MGI:1347061
See related
Ensembl:ENSMUSG00000029802 Vega:OTTMUSG00000022209
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MXR; ABCP; BCRP; MXR1; ABC15; Bcrp1; AI428558
Summary
The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, the human protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. This protein likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. [provided by RefSeq, Jul 2008]
Expression
Broad expression in kidney adult (RPKM 44.7), placenta adult (RPKM 44.0) and 23 other tissues See more
Orthologs
See Abcg2 in Genome Data Viewer
Location:
6 B3; 6 27.82 cM
Exon count:
21
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (58584491..58692451)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (58546666..58642445)

Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene vomeronasal 1 receptor, pseudogene 23 Neighboring gene predicted gene, 35077 Neighboring gene predicted gene, 45943 Neighboring gene predicted gene, 38822 Neighboring gene hect domain and RLD 3 Neighboring gene nucleosome assembly protein 1-like 5

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • ABC transporters, organism-specific biosystem (from KEGG)
    ABC transporters, organism-specific biosystemThe ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of ...
  • ABC transporters, conserved biosystem (from KEGG)
    ABC transporters, conserved biosystemThe ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of ...
  • Abacavir transmembrane transport, organism-specific biosystem (from REACTOME)
    Abacavir transmembrane transport, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Abacavir transport and metabolism, organism-specific biosystem (from REACTOME)
    Abacavir transport and metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Antifolate resistance, organism-specific biosystem (from KEGG)
    Antifolate resistance, organism-specific biosystemSince the 1940s, antifolates have played a pivotal role in drug treatment of malignant, microbial, parasitic and chronic inflammatory diseases. The molecular basis of the anti-proliferative activity ...
  • Antifolate resistance, conserved biosystem (from KEGG)
    Antifolate resistance, conserved biosystemSince the 1940s, antifolates have played a pivotal role in drug treatment of malignant, microbial, parasitic and chronic inflammatory diseases. The molecular basis of the anti-proliferative activity ...
  • Bile secretion, organism-specific biosystem (from KEGG)
    Bile secretion, organism-specific biosystemBile is a vital secretion, essential for digestion and absorption of fats and fat-soluble vitamins in the small intestine. Moreover, bile is an important route of elimination for excess cholesterol a...
  • Bile secretion, conserved biosystem (from KEGG)
    Bile secretion, conserved biosystemBile is a vital secretion, essential for digestion and absorption of fats and fat-soluble vitamins in the small intestine. Moreover, bile is an important route of elimination for excess cholesterol a...
  • Irinotecan Pathway, organism-specific biosystem (from WikiPathways)
    Irinotecan Pathway, organism-specific biosystemThis pathway shows the biotransformation of the chemotherapy prodrug irinotecan to form the active metabolite SN-38, an inhibitor of DNA topoisomerase I. SN-38 is primarily metabolized to the inactiv...
  • Iron uptake and transport, organism-specific biosystem (from REACTOME)
    Iron uptake and transport, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
    Transmembrane transport of small molecules, organism-specific biosystemcomputationally inferred pathway (not manually curated)

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATPase activity IEA
Inferred from Electronic Annotation
more info
 
ATPase activity, coupled to transmembrane movement of substances IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
CONTRIBUTES_TO cholesterol transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoskeletal protein binding ISO
Inferred from Sequence Orthology
more info
 
drug transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
drug transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein dimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
xenobiotic transmembrane transporting ATPase activity EXP
Inferred from Experiment
more info
PubMed 
Process Evidence Code Pubs
cholesterol efflux IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
drug export ISO
Inferred from Sequence Orthology
more info
 
drug transport ISO
Inferred from Sequence Orthology
more info
 
embryonic process involved in female pregnancy ISO
Inferred from Sequence Orthology
more info
 
glucuronoside metabolic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of intestinal absorption ISO
Inferred from Sequence Orthology
more info
 
transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
urate metabolic process ISO
Inferred from Sequence Orthology
more info
 
urate transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Preferred Names
ATP-binding cassette sub-family G member 2
Names
ATP-binding cassette, sub-family G (WHITE), member 2
breast cancer resistance protein 1 homolog
mitoxantrone resistance protein 1
urate exporter

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355477.1NP_001342406.1  ATP-binding cassette sub-family G member 2

    Status: VALIDATED

    Source sequence(s)
    AC121855, AC121859
    Conserved Domains (1) summary
    cl28180
    Location:46651
    PRK10535; macrolide transporter ATP-binding /permease protein; Provisional
  2. NM_011920.3NP_036050.1  ATP-binding cassette sub-family G member 2

    See identical proteins and their annotated locations for NP_036050.1

    Status: VALIDATED

    Source sequence(s)
    AC121855, AC121859, AF103875, AI428558, AK087830, CO039662
    Consensus CDS
    CCDS20195.1
    UniProtKB/Swiss-Prot
    Q7TMS5
    UniProtKB/TrEMBL
    A0A0R4J0B6
    Related
    ENSMUSP00000031822.6, OTTMUSP00000025071, ENSMUST00000031822.12, OTTMUST00000052779
    Conserved Domains (1) summary
    cl28180
    Location:46651
    PRK10535; macrolide transporter ATP-binding /permease protein; Provisional

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

    Range
    58584491..58692451
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241362.1XP_011239664.1  ATP-binding cassette sub-family G member 2 isoform X1

    See identical proteins and their annotated locations for XP_011239664.1

    UniProtKB/Swiss-Prot
    Q7TMS5
    UniProtKB/TrEMBL
    A0A0R4J0B6
    Conserved Domains (1) summary
    cl28180
    Location:46651
    PRK10535; macrolide transporter ATP-binding /permease protein; Provisional
  2. XM_006506151.3XP_006506214.1  ATP-binding cassette sub-family G member 2 isoform X1

    See identical proteins and their annotated locations for XP_006506214.1

    UniProtKB/Swiss-Prot
    Q7TMS5
    UniProtKB/TrEMBL
    A0A0R4J0B6
    Conserved Domains (1) summary
    cl28180
    Location:46651
    PRK10535; macrolide transporter ATP-binding /permease protein; Provisional
  3. XM_006506149.3XP_006506212.1  ATP-binding cassette sub-family G member 2 isoform X1

    See identical proteins and their annotated locations for XP_006506212.1

    UniProtKB/Swiss-Prot
    Q7TMS5
    UniProtKB/TrEMBL
    A0A0R4J0B6
    Conserved Domains (1) summary
    cl28180
    Location:46651
    PRK10535; macrolide transporter ATP-binding /permease protein; Provisional
  4. XM_006506150.3XP_006506213.1  ATP-binding cassette sub-family G member 2 isoform X1

    See identical proteins and their annotated locations for XP_006506213.1

    UniProtKB/Swiss-Prot
    Q7TMS5
    UniProtKB/TrEMBL
    A0A0R4J0B6
    Conserved Domains (1) summary
    cl28180
    Location:46651
    PRK10535; macrolide transporter ATP-binding /permease protein; Provisional
  5. XM_006506148.3XP_006506211.1  ATP-binding cassette sub-family G member 2 isoform X1

    See identical proteins and their annotated locations for XP_006506211.1

    UniProtKB/Swiss-Prot
    Q7TMS5
    UniProtKB/TrEMBL
    A0A0R4J0B6
    Related
    ENSMUSP00000109933.1, OTTMUSP00000025391, ENSMUST00000114294.7, OTTMUST00000053403
    Conserved Domains (1) summary
    cl28180
    Location:46651
    PRK10535; macrolide transporter ATP-binding /permease protein; Provisional
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