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Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) [ Mus musculus (house mouse) ]

Gene ID: 26357, updated on 18-Apr-2024

Summary

Official Symbol
Abcg2provided by MGI
Official Full Name
ATP binding cassette subfamily G member 2 (Junior blood group)provided by MGI
Primary source
MGI:MGI:1347061
See related
Ensembl:ENSMUSG00000029802 AllianceGenome:MGI:1347061
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MXR; ABCP; BCRP; MXR1; ABC15; Bcrp1
Summary
The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, the human protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. This protein likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. [provided by RefSeq, Jul 2008]
Expression
Broad expression in kidney adult (RPKM 44.7), placenta adult (RPKM 44.0) and 23 other tissues See more
Orthologs
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Genomic context

Location:
6 B3; 6 27.82 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (58561476..58669436)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (58584491..58692451)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene vomeronasal 1 receptor, pseudogene 23 Neighboring gene predicted gene, 35077 Neighboring gene predicted gene, 45943 Neighboring gene STARR-seq mESC enhancer starr_16020 Neighboring gene STARR-seq mESC enhancer starr_16022 Neighboring gene STARR-seq mESC enhancer starr_16023 Neighboring gene predicted gene, 38822 Neighboring gene STARR-seq mESC enhancer starr_16024 Neighboring gene STARR-seq mESC enhancer starr_16025 Neighboring gene STARR-seq mESC enhancer starr_16026 Neighboring gene STARR-seq mESC enhancer starr_16027 Neighboring gene hect domain and RLD 3 Neighboring gene nucleosome assembly protein 1-like 5

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables ABC-type xenobiotic transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ATPase-coupled transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables amide transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables biotin transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables cytoskeletal protein binding ISO
Inferred from Sequence Orthology
more info
 
enables efflux transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables efflux transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables efflux transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables organic anion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables riboflavin transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables riboflavin transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables riboflavin transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables urate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables xenobiotic transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in biotin transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular detoxification ISO
Inferred from Sequence Orthology
more info
 
involved_in embryonic process involved in female pregnancy ISO
Inferred from Sequence Orthology
more info
 
involved_in export across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in glucuronoside metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of intestinal absorption ISO
Inferred from Sequence Orthology
more info
 
involved_in organic anion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in renal urate salt excretion ISO
Inferred from Sequence Orthology
more info
 
involved_in riboflavin transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in riboflavin transport ISO
Inferred from Sequence Orthology
more info
 
involved_in transepithelial transport ISO
Inferred from Sequence Orthology
more info
 
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in urate metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in urate transport ISO
Inferred from Sequence Orthology
more info
 
involved_in xenobiotic detoxification by transmembrane export across the plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in xenobiotic transport across blood-brain barrier ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in brush border membrane ISO
Inferred from Sequence Orthology
more info
 
located_in external side of apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
broad substrate specificity ATP-binding cassette transporter ABCG2
Names
ATP-binding cassette sub-family G member 2
ATP-binding cassette, sub-family G (WHITE), member 2
breast cancer resistance protein 1 homolog
mitoxantrone resistance protein 1
urate exporter
NP_001342406.1
NP_001368854.1
NP_001368855.1
NP_001368856.1
NP_036050.1
XP_006506213.1
XP_011239664.1
XP_030111259.1
XP_030111260.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355477.2NP_001342406.1  broad substrate specificity ATP-binding cassette transporter ABCG2

    Status: VALIDATED

    Source sequence(s)
    AC121855, AC121859
    Consensus CDS
    CCDS20195.1
    UniProtKB/Swiss-Prot
    Q7TMS5, Q9R004, Q9Z1T0
    UniProtKB/TrEMBL
    A0A0R4J0B6
    Conserved Domains (1) summary
    TIGR00955
    Location:46651
    3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein
  2. NM_001381925.1NP_001368854.1  broad substrate specificity ATP-binding cassette transporter ABCG2

    Status: VALIDATED

    Source sequence(s)
    AC121855, AC121859
    UniProtKB/Swiss-Prot
    Q7TMS5, Q9R004, Q9Z1T0
    UniProtKB/TrEMBL
    A0A0R4J0B6
    Conserved Domains (1) summary
    TIGR00955
    Location:46651
    3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein
  3. NM_001381926.1NP_001368855.1  broad substrate specificity ATP-binding cassette transporter ABCG2

    Status: VALIDATED

    Source sequence(s)
    AC121855, AC121859
    UniProtKB/Swiss-Prot
    Q7TMS5, Q9R004, Q9Z1T0
    UniProtKB/TrEMBL
    A0A0R4J0B6
    Conserved Domains (1) summary
    TIGR00955
    Location:46651
    3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein
  4. NM_001381927.1NP_001368856.1  broad substrate specificity ATP-binding cassette transporter ABCG2

    Status: VALIDATED

    Source sequence(s)
    AC121859
    UniProtKB/Swiss-Prot
    Q7TMS5, Q9R004, Q9Z1T0
    UniProtKB/TrEMBL
    A0A0R4J0B6
    Related
    ENSMUSP00000109933.2, ENSMUST00000114294.8
    Conserved Domains (1) summary
    TIGR00955
    Location:46651
    3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein
  5. NM_011920.3NP_036050.1  broad substrate specificity ATP-binding cassette transporter ABCG2

    See identical proteins and their annotated locations for NP_036050.1

    Status: VALIDATED

    Source sequence(s)
    AC121855, AC121859, AF103875, AI428558, AK087830, CO039662
    Consensus CDS
    CCDS20195.1
    UniProtKB/Swiss-Prot
    Q7TMS5, Q9R004, Q9Z1T0
    UniProtKB/TrEMBL
    A0A0R4J0B6
    Related
    ENSMUSP00000031822.7, ENSMUST00000031822.13
    Conserved Domains (1) summary
    TIGR00955
    Location:46651
    3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    58561476..58669436
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241362.1XP_011239664.1  broad substrate specificity ATP-binding cassette transporter ABCG2 isoform X1

    See identical proteins and their annotated locations for XP_011239664.1

    UniProtKB/Swiss-Prot
    Q7TMS5, Q9R004, Q9Z1T0
    UniProtKB/TrEMBL
    A0A0R4J0B6
    Conserved Domains (1) summary
    TIGR00955
    Location:46651
    3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein
  2. XM_030255399.2XP_030111259.1  broad substrate specificity ATP-binding cassette transporter ABCG2 isoform X1

    UniProtKB/Swiss-Prot
    Q7TMS5, Q9R004, Q9Z1T0
    UniProtKB/TrEMBL
    A0A0R4J0B6
    Conserved Domains (1) summary
    TIGR00955
    Location:46651
    3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein
  3. XM_030255400.1XP_030111260.1  broad substrate specificity ATP-binding cassette transporter ABCG2 isoform X1

    UniProtKB/Swiss-Prot
    Q7TMS5, Q9R004, Q9Z1T0
    UniProtKB/TrEMBL
    A0A0R4J0B6
    Conserved Domains (1) summary
    TIGR00955
    Location:46651
    3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein
  4. XM_006506150.5XP_006506213.1  broad substrate specificity ATP-binding cassette transporter ABCG2 isoform X1

    See identical proteins and their annotated locations for XP_006506213.1

    UniProtKB/Swiss-Prot
    Q7TMS5, Q9R004, Q9Z1T0
    UniProtKB/TrEMBL
    A0A0R4J0B6
    Conserved Domains (1) summary
    TIGR00955
    Location:46651
    3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein