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OR2L2 olfactory receptor family 2 subfamily L member 2 [ Homo sapiens (human) ]

Gene ID: 26246, updated on 26-Oct-2022

Summary

Official Symbol
OR2L2provided by HGNC
Official Full Name
olfactory receptor family 2 subfamily L member 2provided by HGNC
Primary source
HGNC:HGNC:8266
See related
Ensembl:ENSG00000203663 AllianceGenome:HGNC:8266
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OR1-48; OR2L12; OR2L4P; HTPCRH07; HSHTPCRH07
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See OR2L2 in Genome Data Viewer
Location:
1q44
Exon count:
3
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (248030070..248042305)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (247456121..247468355)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (248193372..248205607)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 2 subfamily L member 13 Neighboring gene olfactory receptor family 2 subfamily L member 6 pseudogene Neighboring gene olfactory receptor family 2 subfamily L member 5 Neighboring gene uncharacterized LOC105373275 Neighboring gene olfactory receptor family 2 subfamily L member 3 Neighboring gene olfactory receptor family 2 subfamily T member 32 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
enables olfactory receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in biological_process ND
No biological Data available
more info
 
involved_in detection of chemical stimulus involved in sensory perception of smell IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
olfactory receptor 2L2
Names
olfactory receptor 2L12
olfactory receptor 2L4
olfactory receptor OR1-48 pseudogene
olfactory receptor, family 2, subfamily L, member 12
olfactory receptor, family 2, subfamily L, member 4 pseudogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004686.3NP_001004686.1  olfactory receptor 2L2 isoform 1

    See identical proteins and their annotated locations for NP_001004686.1

    Status: VALIDATED

    Source sequence(s)
    AC099570
    Consensus CDS
    CCDS31103.1
    UniProtKB/Swiss-Prot
    Q2M3T5, Q8NH16
    UniProtKB/TrEMBL
    A0A126GW34
    Related
    ENSP00000493154.1, ENST00000642011.1
    Conserved Domains (1) summary
    cd15421
    Location:24300
    7tmA_OR2T-like; olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_001385855.1NP_001372784.1  olfactory receptor 2L2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC099570
    Consensus CDS
    CCDS31103.1
    UniProtKB/Swiss-Prot
    Q2M3T5
    UniProtKB/TrEMBL
    A0A126GW34
    Related
    ENSP00000493410.1, ENST00000641771.1
    Conserved Domains (1) summary
    cd15421
    Location:24300
    7tmA_OR2T-like; olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    248030070..248042305
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    247456121..247468355
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)