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GMEB2 glucocorticoid modulatory element binding protein 2 [ Homo sapiens (human) ]

Gene ID: 26205, updated on 21-Dec-2019

Summary

Official Symbol
GMEB2provided by HGNC
Official Full Name
glucocorticoid modulatory element binding protein 2provided by HGNC
Primary source
HGNC:HGNC:4371
See related
Ensembl:ENSG00000101216 MIM:607451
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PIF79; GMEB-2; P79PIF
Summary
This gene is a member of KDWK gene family. The product of this gene associates with GMEB1 protein, and the complex is essential for parvovirus DNA replication. Study of rat homolog implicates the role of this gene in modulation of transactivation by the glucocorticoid receptor bound to glucocorticoid response elements. This gene appears to use multiple polyadenylation sites. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 6.7), testis (RPKM 6.1) and 25 other tissues See more
Orthologs

Genomic context

See GMEB2 in Genome Data Viewer
Location:
20q13.33
Exon count:
11
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (63587602..63627101, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (62218955..62258381, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 13995 Neighboring gene fibronectin type III domain containing 11 Neighboring gene helicase with zinc finger 2 Neighboring gene melanoma highly expressed competing endogenous lncRNA for miR-425 and miR-489 Neighboring gene Sharpr-MPRA regulatory region 12780 Neighboring gene stathmin 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1269

Gene Ontology Provided by GOA

Process Evidence Code Pubs
positive regulation of nucleic acid-templated transcription IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
glucocorticoid modulatory element-binding protein 2
Names
DNA-binding protein p79PIF
PIF p79
parvovirus initiation factor, p79

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012384.5NP_036516.1  glucocorticoid modulatory element-binding protein 2

    See identical proteins and their annotated locations for NP_036516.1

    Status: REVIEWED

    Source sequence(s)
    AK298927, AL121907, AL353715, AW612659, BC036305
    Consensus CDS
    CCDS13528.1
    UniProtKB/Swiss-Prot
    Q9UKD1
    UniProtKB/TrEMBL
    B4DQS0
    Related
    ENSP00000359094.1, ENST00000370077.2
    Conserved Domains (1) summary
    smart00258
    Location:90163
    SAND; SAND domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    63587602..63627101 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005260202.4XP_005260259.1  glucocorticoid modulatory element-binding protein 2 isoform X1

    See identical proteins and their annotated locations for XP_005260259.1

    UniProtKB/Swiss-Prot
    Q9UKD1
    Related
    ENSP00000266068.1, ENST00000266068.5
    Conserved Domains (1) summary
    smart00258
    Location:90163
    SAND; SAND domain
  2. XM_006723776.2XP_006723839.1  glucocorticoid modulatory element-binding protein 2 isoform X2

    See identical proteins and their annotated locations for XP_006723839.1

    Related
    ENSP00000359086.1, ENST00000370069.5
    Conserved Domains (1) summary
    smart00258
    Location:1285
    SAND; SAND domain
  3. XM_011528779.2XP_011527081.1  glucocorticoid modulatory element-binding protein 2 isoform X2

    See identical proteins and their annotated locations for XP_011527081.1

    Conserved Domains (1) summary
    smart00258
    Location:1285
    SAND; SAND domain
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