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INTS1 integrator complex subunit 1 [ Homo sapiens (human) ]

Gene ID: 26173, updated on 7-Jan-2024

Summary

Official Symbol
INTS1provided by HGNC
Official Full Name
integrator complex subunit 1provided by HGNC
Primary source
HGNC:HGNC:24555
See related
Ensembl:ENSG00000164880 MIM:611345; AllianceGenome:HGNC:24555
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
INT1; NET28; NDCAGF
Summary
INTS1 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in testis (RPKM 20.1), kidney (RPKM 10.8) and 25 other tissues See more
Orthologs
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Genomic context

See INTS1 in Genome Data Viewer
Location:
7p22.3
Exon count:
48
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (1470277..1504389, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (1582409..1619912, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (1509913..1544025, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene MICAL like 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:1486489-1486993 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1491449-1492000 Neighboring gene Sharpr-MPRA regulatory region 3173 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1497060-1497782 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1497783-1498505 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17852 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1499929-1500480 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1500481-1501032 Neighboring gene MICALL2 divergent transcript Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1505291-1505986 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:1505987-1506682 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:1509467-1510162 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17853 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1533403-1533903 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17854 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:1545117-1545713 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:1545714-1546309 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17855 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25491 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25492 Neighboring gene INTS1-MAFK intergenic CAGE-defined mid-level expression enhancer Neighboring gene uncharacterized LOC124901572 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:1563055-1563777 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17856 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17857 Neighboring gene uncharacterized LOC100128653 Neighboring gene Sharpr-MPRA regulatory region 13805 Neighboring gene MAF bZIP transcription factor K

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ46624, KIAA1440, DKFZp586J0619

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in U2 snRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in embryo implantation IEA
Inferred from Electronic Annotation
more info
 
involved_in inner cell mass cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription elongation by RNA polymerase II NAS
Non-traceable Author Statement
more info
PubMed 
involved_in snRNA processing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in snRNA processing NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
part_of integrator complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of integrator complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of integrator complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in membrane HDA PubMed 
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
integrator complex subunit 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080453.3NP_001073922.2  integrator complex subunit 1

    See identical proteins and their annotated locations for NP_001073922.2

    Status: VALIDATED

    Source sequence(s)
    AB037861, AC093734, AI935093, BC069262, BF346658, BM547069, BM553299, BX324321, DB113520
    Consensus CDS
    CCDS47526.1
    UniProtKB/Swiss-Prot
    A6NJ44, Q6NT70, Q6UX74, Q8N201, Q8WV40, Q96D36, Q9NTD1, Q9P2A8, Q9Y3W8
    UniProtKB/TrEMBL
    A4D212
    Related
    ENSP00000385722.3, ENST00000404767.8
    Conserved Domains (1) summary
    pfam12432
    Location:350430
    DUF3677; Protein of unknown function (DUF3677)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    1470277..1504389 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011515260.2XP_011513562.1  integrator complex subunit 1 isoform X1

    UniProtKB/TrEMBL
    A4D212
    Conserved Domains (1) summary
    pfam12432
    Location:350430
    DUF3677; Protein of unknown function (DUF3677)
  2. XM_011515262.3XP_011513564.1  integrator complex subunit 1 isoform X2

    Conserved Domains (1) summary
    pfam12432
    Location:350430
    DUF3677; Protein of unknown function (DUF3677)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    1582409..1619912 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054357857.1XP_054213832.1  integrator complex subunit 1 isoform X3

    UniProtKB/Swiss-Prot
    A6NJ44, Q6NT70, Q6UX74, Q8N201, Q8WV40, Q96D36, Q9NTD1, Q9P2A8, Q9Y3W8
    UniProtKB/TrEMBL
    A4D212