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INTS1 integrator complex subunit 1 [ Homo sapiens (human) ]

Gene ID: 26173, updated on 6-Nov-2022

Summary

Official Symbol
INTS1provided by HGNC
Official Full Name
integrator complex subunit 1provided by HGNC
Primary source
HGNC:HGNC:24555
See related
Ensembl:ENSG00000164880 MIM:611345; AllianceGenome:HGNC:24555
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
INT1; NET28; NDCAGF
Summary
INTS1 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in testis (RPKM 20.1), kidney (RPKM 10.8) and 25 other tissues See more
Orthologs
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Genomic context

See INTS1 in Genome Data Viewer
Location:
7p22.3
Exon count:
48
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (1470277..1504389, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (1582409..1616589, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (1509913..1544025, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene MICAL like 2 Neighboring gene Sharpr-MPRA regulatory region 3173 Neighboring gene Sharpr-MPRA regulatory region 1985 Neighboring gene MICALL2 divergent transcript Neighboring gene INTS1-MAFK intergenic CAGE-defined mid-level expression enhancer Neighboring gene uncharacterized LOC124901572

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ46624, KIAA1440, DKFZp586J0619

General protein information

Preferred Names
integrator complex subunit 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080453.3NP_001073922.2  integrator complex subunit 1

    See identical proteins and their annotated locations for NP_001073922.2

    Status: VALIDATED

    Source sequence(s)
    AB037861, AC093734, AI935093, BC069262, BF346658, BM547069, BM553299, BX324321, DB113520
    Consensus CDS
    CCDS47526.1
    UniProtKB/Swiss-Prot
    Q8N201, Q9Y3W8
    Related
    ENSP00000385722.3, ENST00000404767.8
    Conserved Domains (1) summary
    pfam12432
    Location:350430
    DUF3677; Protein of unknown function (DUF3677)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    1470277..1504389 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011515260.2XP_011513562.1  integrator complex subunit 1 isoform X1

    Conserved Domains (1) summary
    pfam12432
    Location:350430
    DUF3677; Protein of unknown function (DUF3677)
  2. XM_011515262.3XP_011513564.1  integrator complex subunit 1 isoform X2

    Conserved Domains (1) summary
    pfam12432
    Location:350430
    DUF3677; Protein of unknown function (DUF3677)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    1582409..1616589 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)